def test_population():
# basic population
ids1 = [i for i in range(10)]
g1 = nngt.NeuralGroup(ids1, neuron_type=1)
ids2 = [i for i in range(10, 20)]
g2 = nngt.NeuralGroup(ids2, neuron_type=-1)
pop = nngt.NeuralPop.from_groups((g1, g2), ("g1", "g2"), with_models=False)
assert "g1" in pop and "g2" in pop
assert set(ids1 + ids2) == set(pop.ids)
assert pop.inhibitory == ids2
assert pop.excitatory == ids1
assert len(pop) == 2
assert pop.size == len(ids1) + len(ids2)
assert pop["g1"].ids == ids1
#add meta groups
g3 = nngt.NeuralGroup(ids1[::2] + ids2[::2], neuron_type=None)
pop.add_meta_group(g3)
g4 = pop.create_meta_group([i for i in range(pop.size) if i % 3], "mg2")
assert g3 in pop.meta_groups.values()
assert g4 in pop.meta_groups.values()
assert set(g2.ids).issuperset(g3.inhibitory)
assert set(g1.ids).issuperset(g3.excitatory)
assert set(g2.ids).issuperset(g4.inhibitory)
assert set(g1.ids).issuperset(g4.excitatory)
# build population from empty one
pop = nngt.NeuralPop()
g5 = pop.create_group([i for i in range(10)],
"group5",
neuron_model="none")
g2.neuron_model = "none"
pop["group2"] = g2
pop.set_model({"neuron": "random_model"})
assert pop.is_valid
# basic populations
pop = nngt.NeuralPop.uniform(100)
assert len(pop) == 1
assert pop.size == 100
pop = nngt.NeuralPop.exc_and_inhib(100)
assert len(pop) == 2
assert len(pop["excitatory"].ids) == 80
assert pop["excitatory"].ids == pop.excitatory
assert len(pop["inhibitory"].ids) == 20
assert pop["inhibitory"].ids == pop.inhibitory
def no_obstacles(shape):
'''
Network generation and simulation without obsacle
Input: shape : nngt spatial shape object to embed the neuron
Output: net : nngt network
Create a Spatial network and seed neurons
Neurons are spread proportionaly to the area
'''
total_area = shape.area
num_neurons = int(density * total_area)
num_excitatory = int(fraction_excitatory * num_neurons)
num_inhibitory = num_neurons - num_excitatory
print("Total number of neurons : {}".format(num_neurons))
print("Excitatory neurons : {}".format(num_excitatory))
print("Inhibitory neurons : {}".format(num_inhibitory))
pop = nngt.NeuralPop(num_neurons, with_model=True)
# # Instruction si on ne veut pas de modèle
# pop.set_model(None)
pop.create_group(num_excitatory,
"excitatory",
neuron_model="aeif_psc_alpha",
neuron_param=params1)
pop.create_group(num_inhibitory,
"inhibitory",
neuron_type=-1,
neuron_model="aeif_psc_alpha",
neuron_param=params1)
# make the graph
net = nngt.SpatialGraph(shape=shape, population=pop)
# seed neurons
excitatory_pos = shape.seed_neurons(num_excitatory,
on_area=shape.default_areas,
soma_radius=15)
excitatory_neurons = np.array(net.new_node(num_excitatory,
positions=excitatory_pos,
groups="excitatory"),
dtype=int)
inhibitory_pos = shape.seed_neurons(num_inhibitory,
on_area=shape.default_areas,
soma_radius=15)
inhibitory_neurons = np.array(net.new_node(num_inhibitory,
positions=inhibitory_pos,
groups="inhibitory",
neuron_type=-1),
dtype=int)
# Establishment of the connectivity
# Scale for the connectivity distance function.
connectivity_scale = 100
print("\n----------\n Connectivity")
print(
"Connectivity characteristic distance {0}".format(connectivity_scale))
print(" (NB: the scale for bottom with obstacles is 100)")
# base connectivity probability
connectivity_proba = 3.
print("Connectivity basic probability {0}".format(connectivity_proba))
print("(Identical between any types of neurons)")
# connect bottom area
for name, area in shape.default_areas.items():
# excitatory to excitatory
print('E > E')
nngt.generation.connect_nodes(net,
excitatory_neurons,
excitatory_neurons,
"distance_rule",
scale=connectivity_scale,
max_proba=connectivity_proba)
# excitatory to inhibitory
print('E > I')
nngt.generation.connect_nodes(net,
excitatory_neurons,
inhibitory_neurons,
"distance_rule",
scale=connectivity_scale,
max_proba=connectivity_proba)
# inhibitory to inhibitory
print('I > I')
nngt.generation.connect_nodes(net,
inhibitory_neurons,
inhibitory_neurons,
"distance_rule",
scale=connectivity_scale,
max_proba=connectivity_proba)
# inhibitory to excitatory
print('I > E')
nngt.generation.connect_nodes(net,
inhibitory_neurons,
excitatory_neurons,
"distance_rule",
scale=connectivity_scale,
max_proba=connectivity_proba)
# Here we set the synaptic weigth. By default synapses are static in net
net.set_weights(synaptic_weigth)
# Graphs output
print('Graphs output')
output_graphs(net, inhibitory_neurons, excitatory_neurons,
[("excitatory", "excitatory"), ("inhibitory", "excitatory"),
("inhibitory", "inhibitory"), ("excitatory", "inhibitory")],
"inhibitory neurons", "excitatory neurons")
# Simulate with NEST
print('Activity simulation')
activity_simulation(net, pop)
def with_obstacles_EI(shape,
params={
"height": 250.,
"width": 250.
},
filling_fraction=0.4):
'''
Network generation and simulation with obstacles and inhibitory neurons
-----------------------------------------------------------------------
Input : shape : nngt defined spatial shape
params : dictionary with obstacles specifications
filling_fraction : float, fraction of the embedding shape filled
with obstacles
Output: nngt network of neurons
'''
''' Create obstacles within the shape'''
shape.random_obstacles(filling_fraction,
form="rectangle",
params=params,
heights=30.,
etching=20.)
''' Create a Spatial network and seed neurons on top/bottom areas '''
# neurons are reparted proportionaly to the area
total_area = shape.area
bottom_area = np.sum([a.area for a in shape.default_areas.values()])
num_bottom = int(density * bottom_area)
num_bottom_E = int(fraction_excitatory * num_bottom)
num_bottom_I = num_bottom - num_bottom_E
# compute number of neurons in each top obstacle according to its area
num_top_list = [] # list for the number of neurons on each top obsatacle
# list for the number of excitatory of neurons on each top obsatacle
num_top_list_E = []
# list for the number of inhibitoryneurons on each top obsatacle
num_top_list_I = []
num_top_total = 0 # count total number of neurons in top obstacles
num_top_E = 0 # count total number of neurons in top obstacles
num_top_I = 0 # count total number of neurons in top obstacles
for name, top_area in shape.non_default_areas.items():
num_top = int(density * top_area.area)
num_excitatory = int(fraction_excitatory * num_top)
num_inhibitory = num_top - num_excitatory
num_top_list.append(num_top)
num_top_list_E.append(num_excitatory)
num_top_list_I.append(num_inhibitory)
num_top_total += num_top
num_top_E += num_excitatory
num_top_I += num_inhibitory
num_neurons = num_bottom + num_top_total # Total number of neurons
num_neurons_E = num_bottom_E + num_top_E # Total number excitatory neurons
num_neurons_I = num_bottom_I + num_top_I # Total number inhibitory neurons
print("Total number of neurons : {0}".format(num_neurons))
print("Bottom neurons : {0}".format(num_bottom))
print("Top neurons : {0}".format(num_top_total))
print("Total number of excitatory neurons : {0}".format(num_neurons_E))
print("Bottom excitatory neurons : {0}".format(num_bottom_E))
print("Top excitatory neurons : {0}".format(num_top_E))
print("Total number of inhibitory neurons : {0}".format(num_neurons_I))
print("Bottom inhibitory neurons : {0}".format(num_bottom_I))
print("Top inhibitory neurons : {0}".format(num_top_I))
pop = nngt.NeuralPop(num_neurons, with_model=True)
# # Instruction si on ne veut pas de modèle
# pop.set_model(None)
# create groups for excitatory and inhibitory bottom neurons
pop.create_group(num_bottom_E,
"bottom_E",
neuron_model="aeif_psc_alpha",
neuron_param=params1)
pop.create_group(num_bottom_I,
"bottom_I",
neuron_model="aeif_psc_alpha",
neuron_param=params1)
# Create groups at the top
def create_top_groups(num_top_list, group_name_prefix, model, params):
''' Creation of neurons groups on the top of obstacles'''
for num_top, (name, top_area) in\
zip(num_top_list, shape.non_default_areas.items()):
# num_top = int(density * top_area.area)
group_name = group_name_prefix + name
if num_top:
pop.create_group(num_top,
group_name,
neuron_model=model,
neuron_param=params)
# Create groups for excitatory neurons on each top area
create_top_groups(num_top_list_E, "top_E_", "aeif_psc_alpha", params1)
# Create groups for inhibitory neurons on each top are
create_top_groups(num_top_list_I, "top_I_", "aeif_psc_alpha", params1)
# make the graph
net = nngt.SpatialGraph(shape=shape, population=pop)
# seed neurons
def seed_bottom_neurons(num_bottom, group_name, neuron_type):
''' Seed botoom neurons'''
bottom_pos = shape.seed_neurons(num_bottom,
on_area=shape.default_areas,
soma_radius=15)
bottom_neurons = np.array(net.new_node(num_bottom,
positions=bottom_pos,
groups=group_name,
neuron_type=neuron_type),
dtype=int)
return bottom_pos, bottom_neurons
print("Seeding bottom neurons")
bottom_pos_E, bottom_neurons_E = seed_bottom_neurons(num_bottom_E,
"bottom_E",
neuron_type=1)
bottom_pos_I, bottom_neurons_I = seed_bottom_neurons(num_bottom_I,
"bottom_I",
neuron_type=-1)
bottom_neurons = []
bottom_neurons.append(list(bottom_neurons_E))
bottom_neurons.append(list(bottom_neurons_I))
bottom_neurons = bottom_neurons[0]
def seed_top_neurons(grp_name_prefix, ntype):
''' Seed top neurons
ntype : neuron type +1 excitatory, -1 inhibitory
'''
top_pos = []
top_neurons = []
top_grp_name_list = []
for name, top_area in shape.non_default_areas.items():
grp_name = grp_name_prefix + name
if grp_name in pop:
# print("Seeding group {}".format(grp_name))
# number of neurons in the top group
num_top = pop[grp_name].size
# print("of size :{0}".format(num_top))
# locate num_top neurons in the group area
top_pos_tmp = top_area.seed_neurons(num_top, soma_radius=15)
top_pos.extend(top_pos_tmp)
seeded_neurons = net.new_node(num_top,
positions=top_pos_tmp,
groups=grp_name,
neuron_type=ntype)
# print seeded_neurons
# previous method return an int, not a list, in case of a
# single node, for extension of top_neurons list we need a list
if type(seeded_neurons) is not list:
seeded_neurons = [seeded_neurons]
top_neurons.extend(seeded_neurons)
top_grp_name_list.append(grp_name)
top_pos = np.array(top_pos)
top_neurons = np.array(top_neurons, dtype=int)
return top_neurons, top_pos, top_grp_name_list
print("Seeding top neurons")
# top_pos_E = []
# top_neurons_E = []
# top_groups_name_list_E = []
top_neurons_E,\
top_pos_E,\
top_groups_name_list_E = seed_top_neurons("top_E_", ntype=1)
# top_pos_I = []
# top_neurons_I = []
# top_groups_name_list_I = []
top_neurons_I,\
top_pos_I,\
top_groups_name_list_I = seed_top_neurons("top_I_", ntype=-1)
# total top neurons groups list
top_groups_name_list = []
top_groups_name_list.append(list(top_groups_name_list_E))
top_groups_name_list.append(list(top_groups_name_list_I))
top_groups_name_list = top_groups_name_list[0]
top_neurons = []
top_neurons.append(list(top_neurons_E))
top_neurons.append(list(top_neurons_I))
top_neurons = top_neurons[0]
# Establishment of the connectivity
# scales for the connectivity distance function.
top_scale = 200. # between top neurons
bottom_scale = 100. # between bottom neurons
mixed_scale = 150. # between top and bottom neurons both ways
print("\n----------\n Connectivity")
print("top neurons connectivity characteristic distance {0}".format(
top_scale))
print("bottom neurons connectivity characteristic distance {0}".format(
bottom_scale))
print("mixed neurons connectivity characteristic distance {0}".format(
mixed_scale))
# base connectivity probability
base_proba = 3.
p_up = 0.6 # modulation for connection bottom to top
p_down = 0.9 # modulation for connection top to bottom
p_other_up = p_down**2 # modulation connection top to top at the bottom
print("Connectivity basic probability {0}".format(base_proba))
print("Up connexion probability on one shape {0}".format(p_up))
print("Down connexion probability {0}".format(p_down))
print("Between two different up shapes connexion probability {0}".format(
p_other_up))
# connect neurons in bottom areas
print("\nConnect bottom areas")
def connect_bottom(neurons_out,
pos_out,
neurons_in,
pos_in,
scale=bottom_scale,
max_proba=base_proba):
''' Connect bottom neurons
connections are only established within continuously connected
areas
'''
for name, area in shape.default_areas.items():
contained = area.contains_neurons(pos_out)
neurons_o = neurons_out[contained]
#print("Neurons out: {}".format(neurons_o))
contained = area.contains_neurons(pos_in)
neurons_i = neurons_in[contained]
#print("Neurons in: {}".format(neurons_i))
nngt.generation.connect_nodes(net,
neurons_o,
neurons_i,
"distance_rule",
scale=scale,
max_proba=max_proba)
# Connect bottom excitatory to bottom excitatory
print("Connect bottom E -> bottom E")
connect_bottom(bottom_neurons_E, bottom_pos_E, bottom_neurons_E,
bottom_pos_E)
# Connect bottom excitatory to bottom inhibitory
print("Connect bottom E -> bottom I")
connect_bottom(bottom_neurons_E, bottom_pos_E, bottom_neurons_I,
bottom_pos_I)
# Connect bottom inhibitory to bottom excitatory
print("Connect bottom I -> bottom E")
connect_bottom(bottom_neurons_I, bottom_pos_I, bottom_neurons_E,
bottom_pos_E)
# Connect bottom inhibitory to bottom inhibitory
print("Connect bottom I -> bottom I")
connect_bottom(bottom_neurons_I, bottom_pos_I, bottom_neurons_I,
bottom_pos_I)
# connect top areas
print("\nConnect top to top")
def connect_top(top_pos_out, top_neurons_out, top_pos_in, top_neurons_in):
'''Connect top areas'''
for name, area in shape.non_default_areas.items():
print("Connexion out of : {}".format(name))
contained = area.contains_neurons(top_pos_out)
neurons_o = top_neurons_out[contained]
print("Neurons out: {}".format(neurons_o))
contained = area.contains_neurons(top_pos_in)
neurons_i = top_neurons_in[contained]
print("Neurons in: {}".format(neurons_i))
other_top_in = [n for n in top_neurons_in if n not in neurons_i]
#print("other_top_in: {}".format(other_top_in))
OO = other_top_in # other_top_in is not as vriable name recognized below !!
if np.any(neurons_o):
# connect intra-area
nngt.generation.connect_nodes(net,
neurons_o,
neurons_i,
"distance_rule",
scale=top_scale,
max_proba=base_proba)
# connect between top areas (do it?)
# These are connection between top neurons seeded on
# different obstacles. Occur probably at the bottom, when
# both neurons' neurites descended.
nngt.generation.connect_nodes(net,
neurons_o,
OO,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba *
p_other_up)
# Connect top excitatory to top excitatory
print("Connect top E -> top E")
connect_top(top_pos_E, top_neurons_E, top_pos_E, top_neurons_E)
# Connect top excitatory to top inhibitory
print("Connect top E -> top I")
connect_top(top_pos_E, top_neurons_E, top_pos_I, top_neurons_I)
# Connect top inhibotory to top excitatory
print("Connect top I -> top E")
connect_top(top_pos_I, top_neurons_I, top_pos_E, top_neurons_E)
# Connect top inhibitory to top inhibitory
print("Connect top I -> top I")
connect_top(top_pos_I, top_neurons_I, top_pos_I, top_neurons_I)
# Connect bottom neurons and top neurons
print("Connect top and bottom")
def connect_top_bottom(top_pos, top_neurons, bottom_neurons):
'''Connect top and bottom areas'''
for name, area in shape.non_default_areas.items():
contained = area.contains_neurons(top_pos)
neurons_top = top_neurons[contained]
print(name)
# print(neurons)
if np.any(neurons_top):
# connect intra-area
# connect the area top neurons to bottom and vice versa
# Connect top to bottom excitatory
nngt.generation.connect_nodes(net,
neurons_top,
bottom_neurons,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba * p_down)
# Connect bottom to top
nngt.generation.connect_nodes(net,
bottom_neurons,
neurons_top,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba * p_up)
# Connect top excitatory to bottom excitatory
print("Connect top E -> bottom E")
connect_top_bottom(top_pos_E, top_neurons_E, bottom_neurons_E)
# Connect top excitatory to bottom inhibitory
print("\nConnect top E -> bottom I")
connect_top_bottom(top_pos_E, top_neurons_E, bottom_neurons_I)
# Connect top inhibitory to bottom excitatory
print("\nConnect top I -> bottom E")
connect_top_bottom(top_pos_I, top_neurons_I, bottom_neurons_E)
# Connect top inhibitory to bottom inhibitory
print("\nConnect top I -> bottom I")
connect_top_bottom(top_pos_I, top_neurons_I, bottom_neurons_I)
# By default synapses are static in net
# Here we set the synaptic weigth
net.set_weights(synaptic_weigth)
# Graphs output
# Define the list of connectivity maps to be plotted
# each tuple of the list contains a list with the groups names of
# neurons for outgoing links and a list of the groups containing
# the neurons towards which the source neurons connect.
#
#restrict = [(top_groups_name_list_E, top_groups_name_list_E)]
restrict = [(top_groups_name_list_E, top_groups_name_list_E),
("bottom_E", top_groups_name_list_E),
(top_groups_name_list_E, "bottom_E"), ("bottom_E", "bottom_E")]
output_graphs(net, top_neurons, bottom_neurons, restrict, "Top neurons",
"Bottom neurons")
# Simulate with NEST
activity_simulation(net, pop, sim_duration)
def with_obstacles(shape,
params={
"height": 250.,
"width": 250.
},
filling_fraction=0.4):
'''
Network generation and simulation with obsactles
------------------------------------------------
Input : shape : nngt defined spatial shape
params : dictionary with obstacles specifications
filling_fraction : float, fraction of the embedding shape filled
with obstacles
Output: nngt network of neurons
'''
''' Create obstacles within the shape'''
shape.random_obstacles(filling_fraction,
form="rectangle",
params=params,
heights=30.,
etching=20.)
''' Create a Spatial network and seed neurons on top/bottom areas '''
# neurons are reparted proportionaly to the area
total_area = shape.area
bottom_area = np.sum([a.area for a in shape.default_areas.values()])
num_bottom = int(density * bottom_area)
# compute number of neurons in each top obstacle according to its area
num_top_list = [] # list for the number of neurons on each top obsatacle
num_top_total = 0 # count tiotal number of neurons in top obstacles
for name, top_area in shape.non_default_areas.items():
num_top = int(density * top_area.area)
num_top_list.append(num_top)
num_top_total += num_top
num_neurons = num_bottom + num_top_total # Total number of neurons
print("Total number of neurons : {0}".format(num_neurons))
print("Bottom neurons : {0}".format(num_bottom))
print("Top neurons : {0}".format(num_top_total))
pop = nngt.NeuralPop(num_neurons, with_model=True)
# # Instruction si on ne veut pas de modèle
# pop.set_model(None)
pop.create_group("bottom",
num_bottom,
neuron_model="aeif_psc_alpha",
neuron_param=params1)
# Create one group on each top area
for num_top, (name, top_area) in zip(num_top_list,
shape.non_default_areas.items()):
# num_top = int(density * top_area.area)
group_name = "top_" + name
if num_top:
pop.create_group(group_name,
num_top,
neuron_model="aeif_psc_alpha",
neuron_param=params1)
# make the graph
net = nngt.SpatialGraph(shape=shape, population=pop)
# seed neurons
bottom_pos = shape.seed_neurons(num_bottom,
on_area=shape.default_areas,
soma_radius=15)
bottom_neurons = np.array(net.new_node(num_bottom,
positions=bottom_pos,
groups="bottom"),
dtype=int)
top_pos = []
top_neurons = []
top_groups_name_list = []
for name, top_area in shape.non_default_areas.items():
group_name = "top_" + name
if group_name in pop:
num_top = pop[group_name].size # number of neurons in top group
# locate num_top neurons in the group area
top_pos_tmp = top_area.seed_neurons(num_top, soma_radius=15)
top_pos.extend(top_pos_tmp)
top_neurons.extend(
net.new_node(num_top, positions=top_pos_tmp,
groups=group_name))
top_groups_name_list.append(group_name)
top_pos = np.array(top_pos)
top_neurons = np.array(top_neurons, dtype=int)
# Establishment of the connectivity
# scales for the connectivity distance function.
top_scale = 200. # between top neurons
bottom_scale = 100. # between bottom neurons
mixed_scale = 150. # between top and bottom neurons both ways
print("\n----------\n Connectivity")
print("top neurons connectivity characteristic distance {0}".format(
top_scale))
print("bottom neurons connectivity characteristic distance {0}".format(
bottom_scale))
print("mixed neurons connectivity characteristic distance {0}".format(
mixed_scale))
# base connectivity probability
base_proba = 3.
p_up = 0.6
p_down = 0.9
p_other_up = p_down**2
print("Connectivity basic probability {0}".format(base_proba))
print("Up connexion probability on one shape {0}".format(p_up))
print("Down connexion probability {0}".format(p_down))
print("Between two different up shapes connexion probability {0}".format(
p_other_up))
# connect bottom area
for name, area in shape.default_areas.items():
contained = area.contains_neurons(bottom_pos)
neurons = bottom_neurons[contained]
# 2018 03 51 I think the use of "bottom_neurons" below is erroneous
# it should be "neurons" as defined above, the neurons in the contained
# area.
# Indeed shape.default_areas.items() is a list with diferent disjoint
# we want to prevent connections between non communicating areas
# at the bottom bottom areas
# nngt.generation.connect_nodes(net, bottom_neurons, bottom_neurons,
# "distance_rule", scale=bottom_scale,
# max_proba=base_proba)
nngt.generation.connect_nodes(net,
neurons,
neurons,
"distance_rule",
scale=bottom_scale,
max_proba=base_proba)
# connect top areas
print("Connect top areas")
for name, area in shape.non_default_areas.items():
contained = area.contains_neurons(top_pos)
neurons = top_neurons[contained]
other_top = [n for n in top_neurons if n not in neurons]
print(name)
# print(neurons)
if np.any(neurons):
# connect intra-area
nngt.generation.connect_nodes(net,
neurons,
neurons,
"distance_rule",
scale=top_scale,
max_proba=base_proba)
# connect between top areas (do it?)
nngt.generation.connect_nodes(net,
neurons,
other_top,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba * p_other_up)
# connect top to bottom
nngt.generation.connect_nodes(net,
neurons,
bottom_neurons,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba * p_down)
# connect bottom to top
nngt.generation.connect_nodes(net,
bottom_neurons,
neurons,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba * p_up)
# By default synapses are static in net
# Here we set the synaptic weigth
net.set_weights(synaptic_weigth)
# Graphs output
# Define the list of connectivity maps to be plotted
# each tuple of the list contains a list with the groups names of
# neurons for outgoing links and a list of the groups containing
# the neurons towards which the ource neurons connect.
#
restrict = [(top_groups_name_list, top_groups_name_list),
("bottom", top_groups_name_list),
(top_groups_name_list, "bottom"), ("bottom", "bottom")]
output_graphs(net, top_neurons, bottom_neurons, restrict, "Top neurons",
"Bottom neurons")
# Simulate with NEST
activity_simulation(net, pop, sim_duration)
ax.set_ylabel("y ($\mu$m)")
ax.grid(False)
plt.show()
print("plot done")
# save
save_path = CleanFolder(os.path.join(os.getcwd(), "2culture_swc"))
ds.io.save_to_swc(filename="2chambers_test.swc", resolution=10)
#~ graph = ds.generate_network(method="spine_based", connection_proba=0.5)
print("\nmaking graph\n")
graph = ds.morphology.generate_network(connection_proba=1)
print("graph generated")
print(graph.node_nb(), graph.edge_nb())
population = nngt.NeuralPop(with_models=False)
population.create_group(range(100), "chamber_1")
population.create_group(range(100, 200), "chamber_2")
nngt.Graph.make_network(graph, population)
print(graph.node_nb(), graph.edge_nb())
graph.to_file("diode.el")
nngt.plot.draw_network(
graph,
ecolor="groups",
ncolor="group", # decimate=5,
show_environment=False,
colorbar=False,
show=True)
def no_obstacles(shape):
'''
Network generation and simulation without obsacles
Input: shape : nngt spatial shape object to embed the neurons
Output: net : nngt network
'''
''' Create a Spatial network and seed neurons on top/bottom areas '''
# neurons are reparted proportionaly to the area
total_area = shape.area
pop = nngt.NeuralPop(num_neurons, with_model=True)
# # Instruction si on ne veut pas de modèle
# pop.set_model(None)
pop.create_group("excitatory",
num_excitatory,
neuron_model="aeif_psc_alpha",
neuron_param=params1)
pop.create_group("inhibitory",
num_inhibitory,
neuron_model="aeif_psc_alpha",
neuron_param=params1)
# make the graph
net = nngt.SpatialGraph(shape=shape, population=pop)
# seed neurons
excitatory_pos = shape.seed_neurons(num_excitatory,
on_area=shape.default_areas,
soma_radius=15)
excitatory_neurons = np.array(net.new_node(num_excitatory,
positions=excitatory_pos,
groups="excitatory"),
dtype=int)
inhibitory_pos = shape.seed_neurons(num_inhibitory,
on_area=shape.non_default_areas,
soma_radius=15)
inhibitory_neurons = np.array(net.new_node(num_inhibitory,
positions=inhibitory_pos,
groups="inhibitory",
ntype=-1),
dtype=int)
''' Make the connectivity '''
#top_scale = 200.
bottom_scale = 100.
#mixed_scale = 150.
base_proba = 3.
p_up = 0.6
p_down = 0.9
p_other_up = p_down**2
# connect bottom area
for name, area in shape.default_areas.items():
# non_default_areas.items() >>.default_areas.items()
contained = area.contains_neurons(excitatory_pos)
neurons = excitatory_neurons[contained]
nngt.generation.connect_nodes(net,
excitatory_neurons,
excitatory_neurons,
"distance_rule",
scale=bottom_scale,
max_proba=base_proba)
nngt.generation.connect_nodes(net,
excitatory_neurons,
inhibitory_neurons,
"distance_rule",
scale=bottom_scale,
max_proba=base_proba)
nngt.generation.connect_nodes(net,
inhibitory_neurons,
inhibitory_neurons,
"distance_rule",
scale=bottom_scale,
max_proba=base_proba)
nngt.generation.connect_nodes(net,
inhibitory_neurons,
excitatory_neurons,
"distance_rule",
scale=bottom_scale,
max_proba=base_proba)
# By default synapses are static in net
# Here we set the synaptic weigth
net.set_weights(50.0)
if plot_distribution is True:
''' Check the degree distribution '''
nngt.plot.degree_distribution(net, ["in", "out"],
num_bins='bayes',
nodes=inhibitory_neurons,
show=False)
nngt.plot.degree_distribution(net, ["in", "out"],
num_bins='bayes',
nodes=excitatory_neurons,
show=True)
if plot_graphs is True:
''' Plot the resulting network and subnetworks '''
restrict = [("excitatory", "excitatory"), ("inhibitory", "excitatory"),
("inhibitory", "inhibitory"), ("excitatory", "inhibitory")]
for r_source, r_target in restrict:
nngt.plot.draw_network(net,
nsize=7.5,
ecolor="groups",
ealpha=0.5,
restrict_sources=r_source,
restrict_targets=r_target,
show=False)
fig, axis = plt.subplots()
count = 0
for r_source, r_target in restrict:
show_env = (count == 0)
nngt.plot.draw_network(net,
nsize=7.5,
ecolor="groups",
ealpha=0.5,
restrict_sources=r_source,
restrict_targets=r_target,
show_environment=show_env,
axis=axis,
show=False)
count += 1
# ~ nngt.plot.draw_network(net, nsize=7.5, ecolor="groups", ealpha=0.5, show=True)
# ------------------ #
# Simulate with NEST #
# ------------------ #
if simulate_activity is True:
print("Activity simulation")
'''
Send the network to NEST, monitor and simulate
'''
activity_simulation(net, pop)
def with_obstacles(shape,
params={
"height": 250.,
"width": 250.
},
filling_fraction=0.4):
'''
Network generation and simulation with obsactles
------------------------------------------------
Input : shape : nngt defined spatial shape
params : dictionary with obstacles specifications
filling_fraction : float, fraction of the embedding shape filled with obstacles
Output: nngt network of neurons
'''
''' Create obstacles within the shape'''
shape.random_obstacles(filling_fraction,
form="rectangle",
params=params,
heights=30.,
etching=20.)
''' Create a Spatial network and seed neurons on top/bottom areas '''
# neurons are reparted proportionaly to the area
total_area = shape.area
bottom_area = np.sum([a.area for a in shape.default_areas.values()])
density = 300e-6
num_bottom = int(density * bottom_area)
pop = nngt.NeuralPop(num_neurons, with_model=True)
# # Instruction si on ne veut pas de modèle
# pop.set_model(None)
pop.create_group("bottom",
num_bottom,
neuron_model="aeif_psc_alpha",
neuron_param=params1)
# Create one group on each top area
for name, top_area in shape.non_default_areas.items():
num_top = int(density * top_area.area)
group_name = "top_" + name
if num_top:
pop.create_group(group_name,
num_top,
neuron_model="aeif_psc_alpha",
neuron_param=params1)
# make the graph
net = nngt.SpatialGraph(shape=shape, population=pop)
# seed neurons
bottom_pos = shape.seed_neurons(num_bottom,
on_area=shape.default_areas,
soma_radius=15)
bottom_neurons = np.array(net.new_node(num_bottom,
positions=bottom_pos,
groups="bottom"),
dtype=int)
top_pos = []
top_neurons = []
for name, top_area in shape.non_default_areas.items():
group_name = "top_" + name
if group_name in pop:
num_top = pop[group_name].size
top_pos_tmp = top_area.seed_neurons(num_top, soma_radius=15)
top_pos.extend(top_pos_tmp)
top_neurons.extend(
net.new_node(num_top, positions=top_pos_tmp,
groups=group_name))
top_pos = np.array(top_pos)
top_neurons = np.array(top_neurons, dtype=int)
''' Make the connectivity '''
top_scale = 200.
bottom_scale = 100.
mixed_scale = 150.
base_proba = 3.
p_up = 0.6
p_down = 0.9
p_other_up = p_down**2
# connect bottom area
for name, area in shape.default_areas.items():
# non_default_areas.items() >>.default_areas.items()
contained = area.contains_neurons(bottom_pos)
neurons = bottom_neurons[contained]
nngt.generation.connect_nodes(net,
bottom_neurons,
bottom_neurons,
"distance_rule",
scale=bottom_scale,
max_proba=base_proba)
# connect top areas
for name, area in shape.non_default_areas.items():
contained = area.contains_neurons(top_pos)
neurons = top_neurons[contained]
other_top = [n for n in top_neurons if n not in neurons]
print(name)
#print(neurons)
if np.any(neurons):
# connect intra-area
nngt.generation.connect_nodes(net,
neurons,
neurons,
"distance_rule",
scale=top_scale,
max_proba=base_proba)
# connect between top areas (do it?)
nngt.generation.connect_nodes(net,
neurons,
other_top,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba * p_other_up)
# connect top to bottom
nngt.generation.connect_nodes(net,
neurons,
bottom_neurons,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba * p_down)
# connect bottom to top
nngt.generation.connect_nodes(net,
bottom_neurons,
neurons,
"distance_rule",
scale=mixed_scale,
max_proba=base_proba * p_up)
# By default synapses are static in net
# Here we set the synaptic weigth
net.set_weights(80.0)
if plot_distribution is True:
''' Check the degree distribution '''
nngt.plot.degree_distribution(net, ["in", "out"],
num_bins='bayes',
nodes=top_neurons,
show=False)
nngt.plot.degree_distribution(net, ["in", "out"],
num_bins='bayes',
nodes=bottom_neurons,
show=True)
if plot_graphs is True:
''' Plot the resulting network and subnetworks '''
restrict = [("bottom", "bottom"), ("top", "bottom"), ("top", "top"),
("bottom", "top")]
for r_source, r_target in restrict:
nngt.plot.draw_network(net,
nsize=7.5,
ecolor="groups",
ealpha=0.5,
restrict_sources=r_source,
restrict_targets=r_target,
show=False)
fig, axis = plt.subplots()
count = 0
for r_source, r_target in restrict:
show_env = (count == 0)
nngt.plot.draw_network(net,
nsize=7.5,
ecolor="groups",
ealpha=0.5,
restrict_sources=r_source,
restrict_targets=r_target,
show_environment=show_env,
axis=axis,
show=False)
count += 1
# ~ nngt.plot.draw_network(net, nsize=7.5, ecolor="groups", ealpha=0.5, show=True)
# ------------------ #
# Simulate with NEST #
# ------------------ #
if simulate_activity is True:
print("Activity simulation")
'''
Send the network to NEST, monitor and simulate
'''
activity_simulation(net, pop)
