def decayfit(t, y, p=(0.05, 0.9), prepend_zero=False, rse=False, lm=False):
"""
Fit exponential decay, y(t) = w exp(-t/tau), to latter part of trajectory.
:param t: time
:param y: variable, e.g. an ion current
:param p: proportion of return to initial value,
as for action potential duration
:param bool prepend_zero: add a 0 at the start of y (hack for use with
ion currents)
:param bool rse: return relative standard error of slope (not of *tau*!).
:param bool lm: Return R object for fitted linear model.
:return tau: -1/slope for estimated slope of log(y) vs t
tau has dimension 'time' and is analogous to half-life: '1/e'-life = 0.37-life.
For use with results from :meth:`Clampable.vecvclamp`, see :func:`decayfits`.
Trivial example.
>>> t = np.arange(10)
>>> y = np.exp(-t)
>>> y[0] = 0
>>> decayfit(t, y)
1.0
Relative standard error when adding noise.
>>> np.random.seed(0)
>>> noisy = y + 0.05 * np.random.random(size=y.shape)
>>> decayfit(t, noisy, rse=True, p=[0.5, 0.99])
(1.292..., 0.045...)
"""
assert len(p) == 2
if prepend_zero:
t = np.r_[0, t]
y = np.r_[0, y]
stats = apd(t, y, p)
_ip, i0, i1 = stats["i"]
# Avoid "Warning message: In is.na(rows) :
# is.na() applied to non-(list or vector) of type 'NULL'"
if i1 <= i0:
tau = rse_slope = np.nan
rlm = None
else:
with roptions(show_error_messages=False, deparse_max_lines=0):
try:
rlm = r.lm("log(y)~t", data=dict(t=t[i0:i1],
y=y[i0:i1].squeeze()))
coef = r2rec(r.as_data_frame(r.coef(r.summary(rlm))))
_intercept, slope = coef.Estimate
_rse_intercept, rse_slope = (coef["Std. Error"] /
abs(coef.Estimate))
tau = - 1.0 / slope
except RRuntimeError:
tau = rse_slope = np.nan
rlm = None
result = (tau,)
if rse:
result += (rse_slope,)
if lm:
result += (rlm,)
return result if len(result) > 1 else result[0]
def markovplot(t, y, a=None, names=None, model=None, comp=None, col="bgrcmyk",
plotpy=False, plotr=True, newfig=True, **legend_kwargs):
"""
Plot markov state distribution for ion channel.
:param array_like t: time
:param recarray y: state
:param recarray a: algebraics
:param names: sequence of variable names to include
:param Cellmlmodel model: Cellmlmodel object
:param str comp: (partial) name of component
:param col: sequence of fill colours for stacked area chart
:param bool plotpy: plot using Python (matplotlib)?
:param bool plotr: plot using R (ggplot2)?
:param bool newfig: create a new figure? (if using matplotlib)
:param ``**legend_kwargs``: passed to matplotlib legend()
If a is None, it will be computed using
``model.rates_and_algebraic(t, y)``.
If names is ``None``, include all "dimensionless" variables whose
component name contains *comp*.
.. ggplot::
from cgp.virtexp.elphys.examples import Bond
from cgp.virtexp.elphys.clampable import markovplot
bond = Bond()
t, y, stats = bond.ap()
p = markovplot(t, y, model=bond, comp="fast_sodium")
"""
t, i = np.unique(t, return_index=True)
y = y[i]
if a is None:
_dy, a = model.rates_and_algebraic(t, y)
else:
a = a[i]
if names is None:
# Often a closed state is defined algebraically as 1 minus the others.
# This puts it apart from other closed states in the list of names
# that we generate below. To remedy this, we sort it.
names = sorted([n for i in "y", "a"
for n, c, u in zip(*model.legend[i])
if comp in c and u == "dimensionless"])
# Distribution only makes sense for at least two states
if len(names) < 2:
return None
# Now put any open state(s) first.
o = [i for i in names if i.startswith("O")]
no = [i for i in names if not i.startswith("O")]
names = o + no
x = np.rec.fromarrays(
[y[k] if k in y.dtype.names else a[k] for k in names], names=names)
xc = x.view(float).cumsum(axis=1).view(x.dtype).squeeze()
if plotr:
from ...utils.rec2dict import rec2dict
r["df"] = r.cbind({"t": t}, r.as_data_frame(rec2dict(x)))
# r["df"] = r.data_frame(t=t, **rec2dict(xc))
# r["df"] = r("df[c('" + "','".join(["t"] + names) + "')]")
r.library("ggplot2")
r.library("jov")
# r.plot(r.df)
r["xm"] = r.melt(r.df, id_var="t")
cmd = ("qplot(t, value, fill=variable, geom='area', position='stack', "
"data=xm) + scale_fill_brewer('State', palette='Set3') + "
"theme_bw() + blankopt")
if comp:
cmd += "+ opts(title='%s')" % comp
return r(cmd)
if plotpy:
from pylab import figure, fill_between, legend, axis, Rectangle
if newfig:
figure()
prev = 0
col = [col[i % len(col)] for i in range(len(names))]
# Workaround for fill_between not being compatible with legend():
# http://matplotlib.sourceforge.net/users/legend_guide.html
# #plotting-guide-legend
symbols = []
labels = []
for i, k in enumerate(x.dtype.names):
kwargs = dict(label=k, facecolor=col[i], edgecolor="none")
fill_between(t, xc[k], prev, **kwargs)
prev = xc[k]
symbols.append(Rectangle((0, 0), 1, 1, **kwargs))
labels.append(k)
axis("tight")
# Reverse to match vertical order
legend(reversed(symbols), reversed(labels), labelspacing=0,
handlelength=1, handletextpad=0.5, borderaxespad=0,
**legend_kwargs)
def markovplots(t, y, a=None, model=None):
"""
Markov plots for all components.
>>> from cgp.virtexp.elphys.examples import Bond
>>> bond = Bond()
>>> t, y, stats = bond.ap()
>>> from cgp.utils.thinrange import thin
>>> i = thin(len(t), 100)
(Below, the ... ellipsis makes doctest ignore messages that R may print
about packages getting loaded. However, doctest output cannot start with
ellipsis, so we need to print something else first. Sigh.)
>>> print "Text output ignored:"; L = markovplots(t[i], y[i], model=bond)
Text output ignored:...
>>> from rnumpy import r
>>> r.windows(record=True) # doctest: +SKIP
>>> print L # doctest: +SKIP
"""
comps = np.unique([c for v in model.legend.values()
for _n, c, _u in zip(*v) if c])
plots = [markovplot(t, y, model=model, comp=comp) for comp in comps]
return [(c, p) for c, p in zip(comps, plots) if p]
if __name__ == "__main__":
import doctest
doctest.testmod(optionflags=doctest.ELLIPSIS | doctest.NORMALIZE_WHITESPACE)
>>> mmfit(x, -y)
(nan, nan)
"""
with roptions(show_error_messages=False, deparse_max_lines=0):
kwargs = dict(formula="y~ymax*x/(x+xhalf)", data=dict(x=x, y=y),
start=dict(ymax=max(y), xhalf=np.mean(x)))
try:
fit = r.nls(**kwargs)
except RRuntimeError, exc:
s = str(exc.exc).split("\n")[1].strip()
errmsg = "Michaelis-Menten fit failed with message '%s'. " % s
errmsg += "Arguments to r.nls() were: %s"
logger.debug(errmsg, kwargs)
ymax = xhalf = rse_ymax = rse_xhalf = np.nan
else:
coef = r2rec(r.as_data_frame(r.coef(r.summary(fit))))
ymax, xhalf = coef.Estimate
rse_ymax, rse_xhalf = coef["Std. Error"] / coef.Estimate
if (ymax < 0) or (xhalf < 0):
errmsg = ("Michalis-Menten fit gave negative estimate(s): "
"ymax=%s, xhalf=%s. Arguments to r.nls() were: %s")
logger.debug(errmsg, ymax, xhalf, kwargs)
ymax = xhalf = rse_ymax = rse_xhalf = np.nan
return (ymax, xhalf, rse_ymax, rse_xhalf) if rse else (ymax, xhalf)
def decayfits(L, i, k, abs_=True):
"""
Convenience wrapper for applying decayfit() to list returned by vecvclamp().
:param L: list of (proto, traj), where *proto* is a list of
(duration, voltage) for each pulse, and *traj* is a list of
