示例#1
0
    
    Experimental conditions:
    1) Fas sensitive cells.
    2) cFlip does not compete with procaspase for binding to FADD 
    3) NFkB mediated cFlip expression
    4) cFlip-L can cleave Bid, but with lower efficiency
    5) RIP1 Hypothesis 1: RIP1-unmod = RIP1-deub
    6) Bid-po4 sequesters RIP1
    7) C3 inhibits MLKL
    
    """
# From irvin_modules
irvin.Initials_Fas_to_DISC()
irvin.TNFR1_to_ComplexII_Initials()
irvin.SecondaryComplex_to_Bid_initials()
irvin.rip1_to_MLKL_initials()

irvin.CD95_to_SecondaryComplex() #1
irvin.FADD_to_C8()
irvin.NFkB_cFlip_interaction() #3
irvin.cFLIP_L_Bid_interaction() #4
irvin.RIP1_Hypothesis_1()#5
irvin.ComplexI_to_NFkB()
irvin.ComplexII_Hypothesis_1() #5
irvin.RIP1_deubiqutination_Hypothesis_1()#5
irvin.RIP1_to_SecondaryComplex()
irvin.RIP1_truncation()
irvin.Bid_Hypothesis() #6
irvin.C8_catalyzed_truncations()
irvin.rip1_to_MLKL()
irvin.C3_inhibits_MLKL()#7
示例#2
0
    1) TNFa sensitive cells.
    2) cFlip competes with procaspase for binding to FADD
    3) NFkB mediated cFlip expression
    4) cFlip-L can cleave Bid, but with lower efficiency
    5) RIP1 Hypothesis 2: RIP1-unmod =! RIP1-deub
        5a) RIP1 de-ubiquitination in the 2o complex
        5a) TRADD can bind RIP1-unmod as well as RIP1-deub
    6) Bid-po4 sequesters RIP1
    7) C3 inhibits MLKL
    
    """
# From irvin_modules
irvin.Initials_Fas_to_DISC()
irvin.TNFR1_to_ComplexII_Initials()
irvin.SecondaryComplex_to_Bid_initials()
irvin.rip1_to_MLKL_initials()

irvin.TNFR1_to_ComplexI()  #1
irvin.FADD_to_C8()
irvin.cFlip_competitive_inhibition()  #2
irvin.NFkB_cFlip_interaction()  #3
irvin.cFLIP_L_Bid_interaction()  #4
irvin.RIP1_Hypothesis_2()  #5
irvin.ComplexI_to_NFkB()
irvin.ComplexII_Hypothesis_2()  #5
irvin.TRADD_RIP1unmod_Hypothesis_2()  #5a
irvin.RIP1_deubiqutination_Hypothesis_1()  #5a
irvin.RIP1_to_SecondaryComplex()
irvin.RIP1_truncation()
irvin.Bid_Hypothesis()  #6
irvin.C8_catalyzed_truncations()