def generate():
r = report.get(report_slug = report_slug)
t = trait.get(report = r, trait_slug = trait_slug)
intervals = list(report.select(mapping) \
.join(mapping) \
.where(
(report.report_slug == report_slug)
&
(mapping.trait == t)
) \
.dicts()
.execute())
yield "\t".join(["report", "trait", "CHROM_POS", "REF", "ALT",
"gene_id", "locus", "feature_id", "transcript_biotype",
"annotation", "putative_impact", "hgvs_p",
"correlation"]) + "\n"
for i in intervals:
for cor in get_correlated_genes(r, t, i["chrom"], i["interval_start"], i["interval_end"]):
for variant in cor["variant_set"]:
line = map(str, [r.report_slug,
t.trait_slug,
variant["CHROM_POS"],
variant["REF"],
variant["ALT"],
variant["gene_id"],
cor["gene_name"],
variant["feature_id"],
cor["transcript_biotype"],
variant["annotation"],
variant["putative_impact"],
variant["hgvs_p"],
variant["correlation"]])
yield '\t'.join(line) + "\n"
def trait_view(report_slug, trait_slug="", rerun=None):
report_data = list(
report.select(report, trait, mapping.trait_id)
.join(trait)
.where(
((report.report_slug == report_slug) & (report.release == 0))
| ((report.report_hash == report_slug) & (report.release > 0))
)
.join(mapping, JOIN.LEFT_OUTER)
.distinct()
.dicts()
.execute()
)
if not report_data:
return render_template("404.html"), 404
if report_data[0]["release"] == 0:
report_url_slug = report_data[0]["report_slug"]
else:
report_url_slug = report_data[0]["report_hash"]
if not trait_slug:
return redirect(url_for("trait_view", report_slug=report_url_slug, trait_slug=report_data[0]["trait_slug"]))
else:
try:
trait_data = [x for x in report_data if x["trait_slug"] == trait_slug][0]
except:
# Redirect user to first trait if it can't be found.
return redirect(url_for("trait_view", report_slug=report_url_slug, trait_slug=report_data[0]["trait_slug"]))
page_title = trait_data["report_name"] + " > " + trait_data["trait_name"]
title = trait_data["report_name"]
subtitle = trait_data["trait_name"]
# Define report and trait slug
report_slug = trait_data["report_slug"] # don't remove
trait_slug = trait_data["trait_slug"] # don't remove
r = report.get(report_slug=report_slug)
t = trait.get(report=r, trait_slug=trait_slug)
# phenotype data
phenotype_data = list(
trait_value.select(strain.strain, trait_value.value)
.join(trait)
.join(report)
.switch(trait_value)
.join(strain)
.where(report.report_slug == r.report_slug)
.where(trait.trait_slug == t.trait_slug)
.dicts()
.execute()
)
if rerun == "rerun":
t.status = "queue"
t.save()
launch_mapping(verify_request=False)
# Return user to current trait
return redirect(url_for("trait_view", report_slug=report_url_slug, trait_slug=trait_slug))
report_trait = "%s/%s" % (report_slug, trait_slug)
base_url = "https://storage.googleapis.com/cendr/" + report_trait
# Fetch significant mappings
mapping_results = list(
mapping.select(mapping, report, trait)
.join(trait)
.join(report)
.filter((report.report_slug == report_slug), (trait.trait_slug == trait_slug))
.dicts()
.execute()
)
#######################
# Variant Correlation #
#######################
var_corr = []
for m in mapping_results:
var_corr.append(correlation.get_correlated_genes(r, t, m["chrom"], m["interval_start"], m["interval_end"]))
tbl_color = {"LOW": "success", "MODERATE": "warning", "HIGH": "danger"}
#######################
# Fetch geo locations #
#######################
geo_gt = {}
for m in mapping_results:
try:
result = GT.fetch_geo_gt(m["chrom"], m["pos"])
geo_gt[m["chrom"] + ":" + str(m["pos"])] = result
except:
pass
geo_gt = json.dumps(geo_gt)
status = trait_data["status"]
# List available datasets
report_files = list(storage.Client().get_bucket("cendr").list_blobs(prefix=report_trait + "/tables"))
report_files = [os.path.split(x.name)[1] for x in report_files]
# Fetch biotypes descriptions
from cendr import biotypes
return render_template("report.html", **locals())