def main():
# Load the dictionaries we need
stopwords_dict = load_dict("stopwords")
hpoterm_phenotype_abnormalities = load_dict(
"hpoterm_phenotype_abnormalities")
# Load the stemmer from NLTK
stemmer = SnowballStemmer("english")
if len(sys.argv) != 2:
sys.stderr.write("USAGE: {} DICT\n".format(sys.argv[0]))
sys.exit(1)
with open(sys.argv[1], 'rt') as dict_file:
for line in dict_file:
# Skip empty lines
if line.strip() == "":
continue
hpo_id, name, definition = line.strip().split("\t")
# Skip if this is not a phenotypic abnormality
if hpo_id not in hpoterm_phenotype_abnormalities:
continue
tokens = name.split()
if len(tokens) == 1:
name_stems = [
tokens[0].casefold(),
]
else:
# Compute the stems of the name
name_stems = set()
for word in tokens:
# Remove parenthesis and commas and colons
if word[0] == "(":
word = word[1:]
if word[-1] == ")":
word = word[:-1]
if word[-1] == ",":
word = word[:-1]
if word[-1] == ":":
word = word[:-1]
# Only process non stop-words AND single letters
if (word.casefold() not in stopwords_dict
and word not in ORDINALS) or len(word) == 1:
# split words that contain a "/"
if word.find("/") != -1:
for part in word.split("/"):
name_stems.add(stemmer.stem(part))
else:
name_stems.add(stemmer.stem(word))
print("\t".join([hpo_id, name, "|".join(name_stems)]))
def main():
# Load the dictionaries we need
stopwords_dict = load_dict("stopwords")
hpoterm_phenotype_abnormalities = load_dict("hpoterm_phenotype_abnormalities")
# Load the stemmer from NLTK
stemmer = SnowballStemmer("english")
if len(sys.argv) != 2:
sys.stderr.write("USAGE: {} DICT\n".format(sys.argv[0]))
sys.exit(1)
with open(sys.argv[1], "rt") as dict_file:
for line in dict_file:
# Skip empty lines
if line.strip() == "":
continue
hpo_id, name, definition = line.strip().split("\t")
# Skip if this is not a phenotypic abnormality
if hpo_id not in hpoterm_phenotype_abnormalities:
continue
tokens = name.split()
if len(tokens) == 1:
name_stems = [tokens[0].casefold()]
else:
# Compute the stems of the name
name_stems = set()
for word in tokens:
# Remove parenthesis and commas and colons
if word[0] == "(":
word = word[1:]
if word[-1] == ")":
word = word[:-1]
if word[-1] == ",":
word = word[:-1]
if word[-1] == ":":
word = word[:-1]
# Only process non stop-words AND single letters
if (word.casefold() not in stopwords_dict and word not in ORDINALS) or len(word) == 1:
# split words that contain a "/"
if word.find("/") != -1:
for part in word.split("/"):
name_stems.add(stemmer.stem(part))
else:
name_stems.add(stemmer.stem(word))
print("\t".join([hpo_id, name, "|".join(name_stems)]))
#! /usr/bin/env python3
from helper.dictionaries import load_dict
if __name__ == "__main__":
merged_genes_dict = load_dict("merged_genes")
inverted_long_names = load_dict("inverted_long_names")
hpoterms_orig = load_dict("hpoterms_orig")
for long_name in inverted_long_names:
for hpoterm_name in hpoterms_orig:
if long_name in hpoterm_name.split() and \
long_name.casefold() != hpoterm_name.casefold():
print("\t".join((long_name, hpoterm_name)))
GENE_KWS = frozenset([
"gene", "oncogene", "protooncogene", "proto-oncogene", "pseudogene",
"transgene"])
COEXPRESSION_KWS = frozenset([
"expression", "overexpression", "over-expression", "co-expression",
"coexpression"])
KEYWORDS = VAR_KWS | KNOCK_KWS | AMINO_ACID_KWS | ANTIGENE_KWS | DNA_KWS | \
DOWNREGULATION_KWS | DOWNREGULATION_KWS | TUMOR_KWS | GENE_KWS | \
COEXPRESSION_KWS
# Load the dictionaries that we need
merged_genes_dict = load_dict("merged_genes")
long_names_dict = load_dict("long_names")
inverted_long_names = load_dict("inverted_long_names")
hpoterms_with_gene = load_dict("hpoterms_with_gene")
stopwords_dict = load_dict("stopwords")
# Add features to a gene mention candidate
def add_features(mention_id, mention_words, sentence):
# The verb closest to the candidate, with the path to it.
minl = 100
minp = None
minw = None
for word in mention_words:
for word2 in sentence.words:
if word2.lemma.isalpha() and re.search('^VB[A-Z]*$', word2.pos) \
"gene", "oncogene", "protooncogene", "proto-oncogene", "pseudogene",
"transgene"
])
COEXPRESSION_KWS = frozenset([
"expression", "overexpression", "over-expression", "co-expression",
"coexpression"
])
KEYWORDS = VAR_KWS | KNOCK_KWS | AMINO_ACID_KWS | ANTIGENE_KWS | DNA_KWS | \
DOWNREGULATION_KWS | DOWNREGULATION_KWS | TUMOR_KWS | GENE_KWS | \
COEXPRESSION_KWS
# Load the dictionaries that we need
merged_genes_dict = load_dict("merged_genes")
long_names_dict = load_dict("long_names")
inverted_long_names = load_dict("inverted_long_names")
hpoterms_with_gene = load_dict("hpoterms_with_gene")
stopwords_dict = load_dict("stopwords")
# Add features to a gene mention candidate
def add_features(mention_id, mention_words, sentence):
# The verb closest to the candidate, with the path to it.
minl = 100
minp = None
minw = None
for word in mention_words:
for word2 in sentence.words:
if word2.lemma.isalpha() and re.search('^VB[A-Z]*$', word2.pos) \
# "EXT_KEYWORD_MIN_[activation]nn@",
# "EXT_KEYWORD_MIN_[oligomerization]nn@",
# "EXT_KEYWORD_MIN_[methylation]prep_of@",
# "EXT_KEYWORD_MIN_[antibody]nn@",
# "EXT_KEYWORD_MIN_[polymorphism]prep_of@",
# "EXT_KEYWORD_MIN_[gene]appos@",
# "EXT_KEYWORD_MIN_[enzyme]@nn",
# "EXT_KEYWORD_MIN_[phosphorylation]prep_of@",
# "EXT_KEYWORD_MIN_[receptor]@nn",
# "EXT_KEYWORD_MIN_[histone]@nn",
# "EXT_KEYWORD_MIN_[receptor]nn",
# "IS_LONG_ALPHANUMERIC_MAIN_SYMBOL", "IS_HYPHENATED_SYMBOL", "IS_LONG_NAME"
# ])
# Load the dictionaries that we need
merged_genes_dict = load_dict("merged_genes")
english_dict = load_dict("english")
stopwords_dict = load_dict("stopwords")
pos_mentions_dict = load_dict("pos_gene_mentions")
neg_mentions_dict = load_dict("neg_gene_mentions")
med_acrons_dict = load_dict("med_acrons")
long_names_dict = load_dict("long_names")
inverted_long_names = load_dict("inverted_long_names")
hpoterms_with_gene = load_dict("hpoterms_with_gene")
# Max mention length. We won't look at subsentences longer than this.
max_mention_length = 0
for key in merged_genes_dict:
length = len(key.split())
if length > max_mention_length:
max_mention_length = length
if frozenset([gene_mention.words[0].word, hpo_entity_id]) in \
genehpoterms_dict:
in_mapping = True
else:
for gene in gene_mention.entity.split("|"):
if frozenset([gene, hpo_entity_id]) in \
genehpoterms_dict:
in_mapping = True
break
if in_mapping:
relation.is_correct = True
relation.type = "GENEHPOTERM_SUP_MAP"
# Load the gene<->hpoterm dictionary
genehpoterms_dict = load_dict("genehpoterms")
if __name__ == "__main__":
# Process input
with fileinput.input() as input_files:
for line in input_files:
# Parse the TSV line
line_dict = get_dict_from_TSVline(
line, ["doc_id", "sent_id", "wordidxs", "words", "poses",
"ners", "lemmas", "dep_paths", "dep_parents",
"bounding_boxes", "gene_entities", "gene_wordidxss",
"gene_is_corrects", "gene_types",
"hpoterm_entities", "hpoterm_wordidxss",
"hpoterm_is_corrects", "hpoterm_types"],
[no_op, int, lambda x: TSVstring2list(x, int), TSVstring2list,
TSVstring2list, TSVstring2list, TSVstring2list,
# "EXT_KEYWORD_MIN_[activation]nn@",
# "EXT_KEYWORD_MIN_[oligomerization]nn@",
# "EXT_KEYWORD_MIN_[methylation]prep_of@",
# "EXT_KEYWORD_MIN_[antibody]nn@",
# "EXT_KEYWORD_MIN_[polymorphism]prep_of@",
# "EXT_KEYWORD_MIN_[gene]appos@",
# "EXT_KEYWORD_MIN_[enzyme]@nn",
# "EXT_KEYWORD_MIN_[phosphorylation]prep_of@",
# "EXT_KEYWORD_MIN_[receptor]@nn",
# "EXT_KEYWORD_MIN_[histone]@nn",
# "EXT_KEYWORD_MIN_[receptor]nn",
# "IS_LONG_ALPHANUMERIC_MAIN_SYMBOL", "IS_HYPHENATED_SYMBOL", "IS_LONG_NAME"
# ])
# Load the dictionaries that we need
merged_genes_dict = load_dict("merged_genes")
english_dict = load_dict("english")
stopwords_dict = load_dict("stopwords")
pos_mentions_dict = load_dict("pos_gene_mentions")
neg_mentions_dict = load_dict("neg_gene_mentions")
med_acrons_dict = load_dict("med_acrons")
long_names_dict = load_dict("long_names")
inverted_long_names = load_dict("inverted_long_names")
hpoterms_with_gene = load_dict("hpoterms_with_gene")
# Max mention length. We won't look at subsentences longer than this.
max_mention_length = 0
for key in merged_genes_dict:
length = len(key.split())
if length > max_mention_length:
max_mention_length = length
is_definition = False
break
definition = " ".join([w.word for w in window_words])
# Only consider this acronym if the definition is valid
if is_definition:
acronym = dict()
acronym["acronym"] = word.word
acronym["definition"] = definition
acronyms.append(acronym)
break
start_idx += 1
return acronyms
# Load the genes dictionary
merged_genes_dict = load_dict("merged_genes")
inverted_long_names = load_dict("inverted_long_names")
if __name__ == "__main__":
# Process the input
with fileinput.input() as input_files:
for line in input_files:
# Parse the TSV line
line_dict = get_dict_from_TSVline(
line,
["doc_id", "sent_ids", "wordidxss", "wordss", "posess",
"nerss", "lemmass", "dep_pathss", "dep_parentss",
"bounding_boxess"],
[no_op, lambda x: TSVstring2list(x, int),
lambda x: TSVstring2list(x,sep='!~!'),
lambda x: TSVstring2list(x,sep='!~!'),
"cronic", "deletion", "detection", "diagnose", "diagnosis", "disease",
"drug", "family", "gene", "genome", "genomic", "genotype", "give", "grade",
"group", "history", "infection", "inflammatory", "injury", "mutation",
"pathway", "phenotype", "polymorphism", "prevalence", "protein", "risk",
"severe", "stage", "symptom", "syndrome", "therapy", "therapeutic",
"treat", "treatment", "variant"
"viruses", "virus"
])
PATIENT_KWS = frozenset(
["boy", "girl", "man", "woman", "men", "women", "patient", "patients"])
KEYWORDS = VAR_KWS | PATIENT_KWS
# Load the dictionaries that we need
english_dict = load_dict("english")
stopwords_dict = load_dict("stopwords")
inverted_hpoterms = load_dict("hpoterms_inverted")
hponames_to_ids = load_dict("hponames_to_ids")
genes_with_hpoterm = load_dict("genes_with_hpoterm")
# hpodag = load_dict("hpoparents")
stems = set()
for hpo_name in inverted_hpoterms:
stem_set = inverted_hpoterms[hpo_name]
stems |= stem_set
stems = frozenset(stems)
# The keys of the following dictionary are sets of stems, and the values are
# sets of hpoterms whose name, without stopwords, gives origin to the
# corresponding set of stems (as key)
if frozenset([gene_mention.words[0].word, hpo_entity_id]) in \
genehpoterms_dict:
in_mapping = True
else:
for gene in gene_mention.entity.split("|"):
if frozenset([gene, hpo_entity_id]) in \
genehpoterms_dict:
in_mapping = True
break
if in_mapping:
relation.is_correct = True
relation.type = "GENEHPOTERM_SUP_MAP"
# Load the gene<->hpoterm dictionary
genehpoterms_dict = load_dict("genehpoterms")
if __name__ == "__main__":
# Process input
with fileinput.input() as input_files:
for line in input_files:
# Parse the TSV line
line_dict = get_dict_from_TSVline(
line,
[
"doc_id", "sent_id", "wordidxs", "words", "poses", "ners",
"lemmas", "dep_paths", "dep_parents", "bounding_boxes",
"gene_entities", "gene_wordidxss", "gene_is_corrects",
"gene_types", "hpoterm_entities", "hpoterm_wordidxss",
"hpoterm_is_corrects", "hpoterm_types"
],
#! /usr/bin/env python3
#
# Extract, add features to, and supervise mentions extracted from geneRifs.
#
import fileinput
from dstruct.Sentence import Sentence
from extract_gene_mentions import extract
from helper.easierlife import get_dict_from_TSVline, TSVstring2list, no_op
from helper.dictionaries import load_dict
if __name__ == "__main__":
# Load the merged genes dictionary
merged_genes_dict = load_dict("merged_genes")
# Process the input
with fileinput.input() as input_files:
for line in input_files:
# Parse the TSV line
line_dict = get_dict_from_TSVline(
line, ["doc_id", "sent_id", "wordidxs", "words", "gene"], [
no_op, int, lambda x: TSVstring2list(x, int),
TSVstring2list, no_op
])
# Create the Sentence object
null_list = [
None,
] * len(line_dict["wordidxs"])
sentence = Sentence(line_dict["doc_id"], line_dict["sent_id"],
line_dict["wordidxs"], line_dict["words"],
null_list, null_list, null_list, null_list,
from dstruct.Mention import Mention
from dstruct.Sentence import Sentence
from helper.dictionaries import load_dict
from helper.easierlife import get_all_phrases_in_sentence, \
get_dict_from_TSVline, TSVstring2list, no_op
DOC_ELEMENTS = frozenset(
["figure", "table", "figures", "tables", "fig", "fig.", "figs", "figs.",
"file", "movie"])
INDIVIDUALS = frozenset(["individual", "individuals", "patient"])
TYPES = frozenset(["group", "type", "class", "method"])
# Load the dictionaries that we need
merged_genes_dict = load_dict("merged_genes")
inverted_long_names = load_dict("inverted_long_names")
hpoterms_with_gene = load_dict("hpoterms_with_gene")
english_dict = load_dict("english")
# Max mention length. We won't look at subsentences longer than this.
max_mention_length = 0
for key in merged_genes_dict:
length = len(key.split())
if length > max_mention_length:
max_mention_length = length
# doubling to take into account commas and who knows what
max_mention_length *= 2
# Supervise the candidates.
is_definition = False
break
definition = " ".join([w.word for w in window_words])
# Only consider this acronym if the definition is valid
if is_definition:
acronym = dict()
acronym["acronym"] = word.word
acronym["definition"] = definition
acronyms.append(acronym)
break
start_idx += 1
return acronyms
# Load the genes dictionary
merged_genes_dict = load_dict("merged_genes")
inverted_long_names = load_dict("inverted_long_names")
if __name__ == "__main__":
# Process the input
with fileinput.input() as input_files:
for line in input_files:
# Parse the TSV line
line_dict = get_dict_from_TSVline(line, [
"doc_id", "sent_ids", "wordidxss", "wordss", "posess", "nerss",
"lemmass", "dep_pathss", "dep_parentss", "bounding_boxess"
], [
no_op, lambda x: TSVstring2list(x, int),
lambda x: TSVstring2list(x, sep='!~!'),
lambda x: TSVstring2list(x, sep='!~!'),
lambda x: TSVstring2list(x, sep='!~!'),
"abnormality", "affect", "apoptosis", "association", "cancer", "carcinoma",
"case", "cell", "chemotherapy", "clinic", "clinical", "chromosome",
"cronic", "deletion", "detection", "diagnose", "diagnosis", "disease",
"drug", "family", "gene", "genome", "genomic", "genotype", "give", "grade",
"group", "history", "infection", "inflammatory", "injury", "mutation",
"pathway", "phenotype", "polymorphism", "prevalence", "protein", "risk",
"severe", "stage", "symptom", "syndrome", "therapy", "therapeutic",
"treat", "treatment", "variant" "viruses", "virus"])
PATIENT_KWS = frozenset(
["boy", "girl", "man", "woman", "men", "women", "patient", "patients"])
KEYWORDS = VAR_KWS | PATIENT_KWS
# Load the dictionaries that we need
english_dict = load_dict("english")
stopwords_dict = load_dict("stopwords")
inverted_hpoterms = load_dict("hpoterms_inverted")
hponames_to_ids = load_dict("hponames_to_ids")
genes_with_hpoterm = load_dict("genes_with_hpoterm")
# hpodag = load_dict("hpoparents")
stems = set()
for hpo_name in inverted_hpoterms:
stem_set = inverted_hpoterms[hpo_name]
stems |= stem_set
stems = frozenset(stems)
# The keys of the following dictionary are sets of stems, and the values are
# sets of hpoterms whose name, without stopwords, gives origin to the
#! /usr/bin/env python3
#
# Extract, add features to, and supervise mentions extracted from geneRifs.
#
import fileinput
from dstruct.Sentence import Sentence
from extract_gene_mentions import extract
from helper.easierlife import get_dict_from_TSVline, TSVstring2list, no_op
from helper.dictionaries import load_dict
if __name__ == "__main__":
# Load the merged genes dictionary
merged_genes_dict = load_dict("merged_genes")
# Process the input
with fileinput.input() as input_files:
for line in input_files:
# Parse the TSV line
line_dict = get_dict_from_TSVline(
line, ["doc_id", "sent_id", "wordidxs", "words", "gene"],
[no_op, int, lambda x: TSVstring2list(x, int), TSVstring2list,
no_op])
# Create the Sentence object
null_list = [None, ] * len(line_dict["wordidxs"])
sentence = Sentence(
line_dict["doc_id"], line_dict["sent_id"],
line_dict["wordidxs"], line_dict["words"], null_list,
null_list, null_list, null_list, null_list, null_list)
# This is the 'labelled' gene that we know is in the sentence
gene = line_dict["gene"]
#! /usr/bin/env python3
#
# Canonicalize a dump using the HPO dag
#
# Use the output of filter_out_uncertain_genes.py
import sys
from helper.dictionaries import load_dict
if len(sys.argv) != 2:
sys.stderr.write("USAGE: {} dump.tsv\n".format(sys.argv[0]))
sys.exit(1)
hpoancestors = load_dict("hpoancestors")
with open(sys.argv[1], 'rt') as dump:
for line in dump:
tokens = line.strip().split("\t")
relation_id = tokens[0]
gene_entity = tokens[1]
hpo_entity = tokens[3]
if "|" not in hpo_entity:
continue
hpo_id = hpo_entity.split("|")[0]
if hpo_id not in hpoancestors:
continue
print("{}\t{}\t{}".format(relation_id, gene_entity, hpo_entity))
for ancestor in hpoancestors[hpo_id]:
print("{}\t{}\t{}".format(relation_id, gene_entity, ancestor))
threeh_suffixes = threeh_singles
full_singles = frozenset(("outcalls", "outcall", "overnite"))
full_suffixes = full_singles
two_grams_prefixes = frozenset((
"1/2", "1/2", "half", "1.5", "hlf", "full", "an hour", "a hr", "whole", "multiple", "additional", "first", "multi", "add", "complete"))
two_grams_durations = frozenset((
"quick visits", "quick visit", "quick fix", "short stay", "short visit", "quick stay", "short fix"))
singles = quick_singles | half_singles | hour_singles | fourtyfive_singles | \
twoh_singles | threeh_singles
suffixes = quick_suffixes | half_suffixes | hour_suffixes | \
fourtyfive_suffixes | twoh_suffixes | threeh_suffixes | min_suffixes
STOP_WORDS = load_dict("stopwords")
ALL_ENGLISH_WORDS = load_dict("english") - \
(singles | suffixes | two_grams_prefixes | {"quick", })
sregex_1w_num_min = re.compile("^(15|20|30|45|60|90|120)/?-?min")
sregex_1w_num_hour = re.compile("^(1|2|3|one|two|three)/?-?h")
regex_min = re.compile("min$|mins|minut")
regex_half = re.compile("hlf|half")
regex_hh = re.compile("hh")
regex_slash = re.compile("/")
regex_hour = re.compile("hrs?$|hours?")
regex_hyphen = re.compile("-")
regex_common_minute_number = re.compile(
"15$|15\D+|30$|30\D+|45$|45\D+|60$|60\D+|90$|90\D+")
regex_common_hour_spelled = re.compile("one|two|three")
