class NurseModel(RidDocument):
rid = SequenceField(
unique=True
) # Overriding to use own counter rather than the one common to all RidDocument childs.
user = ReferenceField(UserModel,
required=True,
unique=True,
reverse_delete_rule=2)
name = StringField(min_lenght=1, max_length=255, required=True)
treatment_types = ListField(ReferenceField(TreatmentTypeModel,
required=False),
default=list)
agenda = SortedListField(DateTimeField(), required=False, default=list())
def clean(self):
errs = dict()
self.agenda.sort()
for i in range(len(self.agenda) - 1):
if self.agenda[i].date() == self.agenda[i + 1].date():
errs["agenda"] = "Can only have one agenda per day!"
duplicates = find_duplicates(self.treatment_types)
if duplicates:
errs[
"treatment_types"] = f"Treatment types list cannot contains duplicate elements."
if errs:
raise ValidationError(errors=errs)
class Course(db.Document):
no = StringField(required=True)
name = StringField(required=True)
teacher = ReferenceField(Teacher, required=True)
teacher_name = StringField(required=True)
credit = StringField()
detail = StringField(default="")
target = StringField(default="")
like = ListField(ReferenceField(User, deref=True), default=lambda: [])
like_count = IntField(default=0)
refrences = StringField(default="")
heat = IntField(default=0)
evaluations_count = IntField(default=0)
# evaluations = ListField(ReferenceField(Evaluation), default=lambda: [])
rating = FloatField(default=lambda: 0, required=True)
school = StringField(required=True)
category = StringField(default="")
tags = ListField(StringField(), default=lambda: [])
terms = SortedListField(StringField(), reverse=True, default=lambda: [])
meta = {
'strict': False,
'ordering': ['-heat'],
'indexes': ['heat', 'credit', 'no', 'name', 'teacher_name']
}
def __unicode__(self):
return '{}-{}-{}'.format(self.name, self.no, self.teacher)
class PlanoAula(Document):
professor = ReferenceField(User)
disciplina = ReferenceField(Disciplina)
curso = ReferenceField(Curso)
turma = StringField()
turno = StringField()
data = DateTimeField()
aulas = SortedListField(EmbeddedDocumentField(Aula), ordering="data")
#etapas = ListField(Etapa)
ac1 = ListField(AtvPeso, default=[])
ac2 = ListField(AtvPeso, default=[])
af = ListField(StringField(), default=[])
sub = ListField(StringField(), default=[])
def to_dict(self):
aulas_array = []
for aula in self.aulas:
aulas_array.append(aula)
return dict(id=str(self.pk),
professor=dict(id=str(self.professor.pk),
nome=self.professor.name),
disciplina=dict(id=str(self.disciplina.pk),
nome=self.disciplina.nome),
curso=dict(id=str(self.curso.pk), nome=self.curso.nome),
turno=self.turno,
turma=self.turma,
aulas=aulas_array)
class Habit(Document, AuditableModel):
name = StringField(max_length=1024, required=True)
past_goals = ListField(EmbeddedDocumentField(Goal))
user = ReferenceField(User, required=True)
public = BooleanField(required=True)
x_list = SortedListField(StringField())
daily_goal = EmbeddedDocumentField(Goal)
start_date = DateTimeField(required=True)
end_date = DateTimeField(default=None)
def create_habit(self, user, **kwargs):
start_date, end_date = map(
lambda x: arrow.get(x).datetime
if x else None, (kwargs.get('start_date'), kwargs.get('end_date')))
if kwargs.get('type') == "daily":
new_daily_goal = DailyGoal(type=kwargs.get('type'),
label_text=kwargs.get('label_text'))
self.daily_goal = new_daily_goal
self.user = user
self.name = kwargs.get('name')
self.start_date = start_date or arrow.now().datetime
self.public = kwargs.get('public')
self.end_date = end_date
return super(Habit, self).save()
class History(Document):
user = ReferenceField(User, unique=True)
records = SortedListField(EmbeddedDocumentField(Record),
ordering="timestamp",
reverse=True)
@staticmethod
def get_history_records(user, limit=5):
"""get_history"""
history = History.objects(user=user).first()
if history:
return history.records[:limit]
else:
return []
@staticmethod
def insert_history_record(user, msg):
"""insert history to a user"""
record = Record(msg=msg)
history = History.objects(user=user).first()
if not history:
history = History(user=user, records=[])
history.records.append(record)
history.save()
return record
class User(Document):
username = StringField(unique=True, required=True)
email = StringField(unique=True, required=True)
password = StringField(required=True)
# currently email is enabled
groups = SortedListField(EmbeddedDocumentField(Group),
ordering='groupName')
meta = {'ordering': ['+username']}
class Topic(Document): # TODO Add indexes
name = StringField(required=True)
category = ReferenceField(Category)
user = ReferenceField(User)
creation_date = DateTimeField(default=datetime.utcnow)
last_post_date = DateTimeField()
posts = SortedListField(EmbeddedDocumentField(Post),
ordering="post_date",
reverse=True)
class Transaction(Document):
giver = ReferenceField(User)
recipient = ReferenceField(User)
amount = IntField()
reason = StringField()
category = StringField()
upvote = IntField()
downvote = IntField()
voters = SortedListField(ReferenceField(User), ordering='name')
thanks = BooleanField()
createdate = DateTimeField()
class DeletedComment(CommentBase):
""" Comment that was deleted.
Used for comment parents and acts as a placeholder.
"""
replies = SortedListField(ReferenceField('Comment'), default=list())
timestamp = DateTimeField(required=True, default=datetime.now())
def to_json(self):
return super(DeletedComment, self).to_json()
class Calendar(db.Document, ModelCore):
name = StringField(required=True, unique=True)
room_size = IntField(required=True)
therapies = SortedListField(field=StringField(max_length=20))
def to_dict(self):
serial = {}
serial['name'] = self.name
serial['room_size'] = self.room_size
serial['therapies'] = self.therapies
return serial
class CommentBase(Document, JsonMixin, TimestampOrderableMixin):
replies = SortedListField(ReferenceField('Comment'), default=list())
timestamp = DateTimeField(required=True, default=datetime.now())
meta = {
'allow_inheritance': True,
'abstract': True,
}
@property
def parent(self):
return self.__class__.objects(replies__in=[
self,
]).first()
class Transaction(mgo.Document):
giver = ReferenceField(User)
recipient = ReferenceField(User)
amount = mgo.IntField(required='true')
reason = StringField()
category = StringField()
upvote = IntField()
downvote = IntField()
voters = SortedListField(ReferenceField(User), ordering='name')
thanks = BooleanField()
# createdate = DateTimeField(default=datetime.now())
createdate = DateTimeField()
meta = {
'ordering': ['+createdate']
}
class ExerciseLog(Document):
user = ReferenceField(User, required=True)
wordname = StringField(required=True)
word = ReferenceField(Word, required=True)
review = DateTimeField(required=True)
sentences = SortedListField(EmbeddedDocumentField(SentenceLog),
ordering="time",
reverse=True)
def calucate_review(self):
count = 0
for s in reversed(self.sentences):
if not s.result:
break
count += 1
delta = ebbinghaus.get(count, timedelta(days=15))
self.review = datetime.utcnow() + delta
@classmethod
def review_count(cls, user, start, end):
data = ExerciseLog.objects(user=user, review__gt=start, review__lt=end).\
aggregate(
{'$group' : {'_id' : {'$dateToString' : {
'date': "$review",
'format': "%Y/%m/%d",
} }, 'count' : { '$sum' : 1 }}},
{'$sort': {'_id': 1}}
)
return {i['_id']: i['count'] for i in list(data)}
@classmethod
def exercise_count(cls, user, start, end):
data = ExerciseLog.objects(user=user).\
aggregate(
{"$match": {"sentences.time": {"$gte": start, "$lte": end}}},
{"$project":{'_id':0, 'sentences.time': 1, 'sentences.result':1}},
{"$unwind":"$sentences"},
{"$match": {"sentences.time": {"$gte": start, "$lte": end}}},
{'$project': {'day': '$sentences.time',
'result': '$sentences.result'}},
{'$group': { '_id': {'$dateToString' : {
'date': "$day",
'format': "%Y/%m/%d",
} }, 'count': { '$sum': 1 } } },
{'$sort': {'_id': 1}}
)
return {i['_id']: i['count'] for i in list(data)}
class Therapist(db.Document, ModelCore):
name = StringField(required=True, max_length=200)
slug = StringField(required=True, max_length=20)
phone = StringField(required=True, max_length=20)
email = EmailField(required=True, max_length=50, unique=True)
specialties = SortedListField(field=StringField(max_length=20))
last_modified = DateTimeField(default=datetime.now)
def to_dict(self):
serial = {}
serial['name'] = self.name
serial['slug'] = self.slug
serial['phone'] = self.phone
serial['email'] = self.email
serial['last_modified'] = self.last_modified
serial['specialties'] = self.specialties
return serial
class Discussion(JsonMixin, Document):
""" User comments pertaining to a part of 1Base.
As with any wiki, a disagreement may arise. Discussions are there to
allow users to state ther opinion on a particular issue.
"""
title = StringField()
comments = SortedListField(ReferenceField(Comment), required=True)
is_locked = BooleanField(default=False)
meta = {
'allow_inheritance': True,
}
@property
def starter(self):
""" Return the comment that started the discussion. """
return self.comments[0]
class Post(PermissionMixin, Document):
author = ReferenceField('users.User', reverse_delete_rule=CASCADE)
title = StringField(max_length=120, required=True)
content = StringField(max_length=1024, required=True)
tags = ListField(StringField(max_length=50))
comments = SortedListField(EmbeddedDocumentField(Comment))
page_views = IntField(default=0)
create_time = DateTimeField(default=timezone.now)
__object_name__ = 'Post'
__acl__ = [
(Allow, EveryOne, 'view'),
(Allow, Authenticated, 'add'),
(Allow, Owner, 'change'),
(Allow, Owner, 'delete'),
]
meta = {
'ordering': ['-create_time'],
}
@classmethod
def get_by_id(cls, id):
return cls.objects.get(id=id)
@classmethod
def create_post(cls, username, title, content):
user = User.get_by_uesrname(username)
post = cls(author=user, title=title, content=content)
post.save()
return post
def is_owner(self, username):
return self.author.username == username
@property
def last_comment(self):
return self.comments[-1]
class ContestRank(Document):
contest_pk = IntField(required=True)
user = SortedListField(ReferenceField(RankUser))
class Day(EmbeddedDocument):
date = StringField(required=True)
status = StringField(default='P')
members = SortedListField(EmbeddedDocumentField(Member), ordering='name')
class ObjQnA(QnA):
content = SortedListField(EmbeddedDocumentField(ObjQnAContent),
ordering='version',
reverse=True,
required=True)
class Group(EmbeddedDocument):
groupName = StringField(required=True)
allMembers = SortedListField(EmbeddedDocumentField(Member),
ordering='name')
calendar = SortedListField(EmbeddedDocumentField(Day), ordering='date')
class Variant(Document):
# document_id is a md5 string created by institute_genelist_caseid_variantid:
document_id = StringField(primary_key=True)
# variant_id is a md5 string created by variant_id
variant_id = StringField(required=True)
# display name in variant_id (no md5)
display_name = StringField(required=True)
# The variant can be either a reserch variant or a clinical variant.
# For research variants we display all the available information while
# the clinical variants hae limited annotation fields.
variant_type = StringField(required=True, choices=('research', 'clinical'))
# case_id is a string like owner_caseid
case_id = StringField(required=True)
chromosome = StringField(required=True)
position = IntField(required=True)
reference = StringField(required=True)
alternative = StringField(required=True)
rank_score = FloatField(required=True)
variant_rank = IntField(required=True)
institute = ReferenceField('Institute', required=True)
quality = FloatField()
filters = ListField(StringField())
samples = ListField(EmbeddedDocumentField(GTCall))
genetic_models = ListField(StringField(choices=GENETIC_MODELS))
compounds = SortedListField(EmbeddedDocumentField(Compound),
ordering='combined_score',
reverse=True)
genes = ListField(EmbeddedDocumentField(Gene))
db_snp_ids = ListField(StringField())
# Gene ids:
hgnc_symbols = ListField(StringField())
ensembl_gene_ids = ListField(StringField())
# Frequencies:
thousand_genomes_frequency = FloatField()
exac_frequency = FloatField()
local_frequency = FloatField()
# Predicted deleteriousness:
cadd_score = FloatField()
clnsig = IntField()
@property
def has_comments(self):
"""
Return True is there are any comments for this variant in the database
"""
if Event.objects(verb='comment',
variant_id=self.variant_id,
institute=self.institute):
return True
return False
@property
def clnsig_human(self):
return {
0: 'Uncertain significance',
1: 'not provided',
2: 'Benign',
3: 'Likely benign',
4: 'Likely pathogenic',
5: 'Pathogenic',
6: 'drug response',
7: 'histocompatibility',
255: 'other'
}.get(self.clnsig, 'not provided')
# Conservation:
phast_conservation = ListField(StringField(choices=CONSERVATION))
gerp_conservation = ListField(StringField(choices=CONSERVATION))
phylop_conservation = ListField(StringField(choices=CONSERVATION))
# Database options:
gene_lists = ListField(StringField())
expected_inheritance = ListField(StringField())
manual_rank = IntField(choices=[0, 1, 2, 3, 4, 5])
acmg_evaluation = StringField(choices=ACMG_TERMS)
@property
def omim_annotations(self):
"""Returns a list with OMIM id(s)."""
if len(self.genes) == 1:
annotations = (str(gene.omim_gene_entry) for gene in self.genes
if gene.omim_gene_entry)
else:
annotations = (':'.join(
[gene.hgnc_symbol, str(gene.omim_gene_entry)])
for gene in self.genes if gene.omim_gene_entry)
# flatten the list of list of omim ids
return annotations
@property
def omim_annotation_links(self):
"""Return a list of OMIM id links."""
base_url = 'http://www.omim.org/entry'
for omim_id_str in self.omim_annotations:
# handle cases with variant overlapping multiple genes
omim_id_parts = omim_id_str.split(':')
if len(omim_id_parts) == 1:
# single gene overlap
omim_id = omim_id_parts[0]
else:
# multiple genes
omim_id = omim_id_parts[1]
yield (omim_id_str, "{base}/{id}".format(base=base_url,
id=omim_id))
@property
def omim_phenotypes(self):
"""Return a list of OMIM phenotypes with related gene information."""
for gene in self.genes:
for phenotype in gene.omim_phenotypes:
yield gene, phenotype
@property
def omim_inheritance_models(self):
"""Return a list of OMIM inheritance models (phenotype based)."""
models = ((phenotype.disease_models
for phenotype in gene.omim_phenotypes)
for gene in self.genes)
# untangle multiple nested list of list of lists...
return set(
itertools.chain.from_iterable(
itertools.chain.from_iterable(models)))
@property
def region_annotations(self):
"""Returns a list with region annotation(s)."""
region_annotations = []
if len(self.genes) == 1:
return [gene.region_annotation for gene in self.genes]
else:
for gene in self.genes:
region_annotations.append(':'.join(
[gene.hgnc_symbol, gene.region_annotation]))
return region_annotations
@property
def sift_predictions(self):
"""Return a list with the sift prediction(s) for this variant.
The most severe for each gene.
"""
sift_predictions = []
if len(self.genes) == 1:
sift_predictions = [(gene.sift_prediction or '-')
for gene in self.genes]
else:
for gene in self.genes:
sift_predictions.append(':'.join(
[gene.hgnc_symbol, gene.sift_prediction or '-']))
return sift_predictions
@property
def polyphen_predictions(self):
"""Return a list with the polyphen prediction(s) for this variant.
The most severe for each gene.
"""
polyphen_predictions = []
if len(self.genes) == 1:
polyphen_predictions = [(gene.polyphen_prediction or '-')
for gene in self.genes]
else:
for gene in self.genes:
polyphen_predictions.append(':'.join(
[gene.hgnc_symbol, gene.polyphen_prediction or '-']))
return polyphen_predictions
@property
def is_matching_inheritance(self):
"""Match expected (OMIM) with annotated inheritance models."""
omim_models = self.omim_inheritance_models
for model in self.genetic_models:
for omim_model in omim_models:
if (model == omim_model) or (omim_model in model):
return True
return False
@property
def functional_annotations(self):
"""Return a list with the functional annotation(s) for this variant. The most severe for each gene."""
functional_annotations = []
if len(self.genes) == 1:
functional_annotations = [
gene.functional_annotation for gene in self.genes
]
else:
for gene in self.genes:
functional_annotations.append(':'.join(
[gene.hgnc_symbol, gene.functional_annotation or '']))
return functional_annotations
@property
def transcripts(self):
"""Yield all transcripts as a flat iterator.
For each transcript both the parent gene object as well as the
transcript is yielded.
Yields:
class, class: Gene and Transcript ODM
"""
# loop over each gene in order
for gene in self.genes:
# loop over each child transcript for the gene
for transcript in gene.transcripts:
# yield the parent gene, child transcript combo
yield transcript
@property
def refseq_transcripts(self):
"""Yield all transcripts with a RefSeq id."""
for transcript in self.transcripts:
if transcript.refseq_ids:
yield transcript
@property
def protein_changes(self):
for transcript in self.refseq_transcripts:
yield transcript.stringify()
@property
def end_position(self):
# bases contained in alternative allele
alt_bases = len(self.alternative)
# vs. reference allele
bases = max(len(self.reference), alt_bases)
return self.position + (bases - 1)
# This is exactly the same as variant_id...
@property
def frequency(self):
"""Returns a judgement on the overall frequency of the variant.
Combines multiple metrics into a single call.
"""
most_common_frequency = max(self.thousand_genomes_frequency,
self.exac_frequency)
if most_common_frequency > .05:
return 'common'
elif most_common_frequency > .01:
return 'uncommon'
else:
return 'rare'
@property
def manual_rank_level(self):
return {
1: 'low',
2: 'low',
3: 'medium',
4: 'medium',
5: 'high'
}.get(self.manual_rank, 'unknown')
@property
def exac_link(self):
"""Compose link to ExAC website for a variant position."""
url_template = ("http://exac.broadinstitute.org/variant/"
"{this.chromosome}-{this.position}-{this.reference}"
"-{this.alternative}")
return url_template.format(this=self)
@property
def ucsc_link(self):
url_template = (
"http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&"
"position=chr{this.chromosome}:{this.position}-{this.position}&dgv=pack&knownGene=pack&omimGene=pack"
)
return url_template.format(this=self)
def __unicode__(self):
return self.display_name