B_B=0,
B_C=1,
B_vhalf=0.03,
B_vslope=-0.012)
HCN1_Y_params=[]
HCN2param = ChannelSettings(Xpow=1, Ypow=0, Zpow=0, Erev=hcnrev, name='HCN2')
HCN2_X_params = AlphaBetaChannelParams(A_rate=4.051659010859005,
A_B=0.0,
A_C=1,
A_vhalf=0.09511840967666049,
A_vslope=0.01,
B_rate=2.7011060072393365,
B_B=0.0,
B_C=1,
B_vhalf=-0.02488159032333951,
B_vslope=-0.012)
HCN2_Y_params=[]
Channels = NamedDict(
'Channels',
KDr = TypicalOneD(KDrparam, KDr_X_params, KDr_Y_params),
Kv3 = TypicalOneD(Kv3param, Kv3_X_params, Kv3_Y_params),
KvF = TypicalOneD(KvFparam, KvF_X_params, KvF_Y_params),
KvS = TypicalOneD(KvSparam, KvS_X_params, KvS_Y_params),
HCN1 = TypicalOneD(HCN1param,HCN1_X_params, []),
HCN2 = TypicalOneD(HCN2param,HCN2_X_params, []),
NaF = TypicalOneD(NaFparam, Na_m_params, Na_h_params),
)
SKparam = ChannelSettings(Xpow=0, Ypow=0, Zpow=1, Erev=krev, name='SKCa')
SK_Z_params = ZChannelParams(Kd=0.00035,
power=4.6,
tau=0.002,
taumax=0.0037928,
tau_power=4.3,
cahalf=0.002703)
# BK channel
BKparam = ChannelSettings(Xpow=1, Ypow=0, Zpow=0, Erev=krev, name='BKCa')
BK_X_params = [
BKChannelParams(alphabeta=480, K=0.18, delta=-0.84),
BKChannelParams(alphabeta=280, K=0.011, delta=-1.0)
]
Channels = NamedDict(
'Channels',
KDr=TypicalOneD(KDrparam, KDr_X_params, KDr_Y_params),
Kv3=TypicalOneD(Kv3param, Kv3_X_params, Kv3_Y_params),
KvF=TypicalOneD(KvFparam, KvF_X_params, KvF_Y_params),
KvS=TypicalOneD(KvSparam, KvS_X_params, KvS_Y_params),
HCN1=TypicalOneD(HCN1param, HCN1_X_params, []),
HCN2=TypicalOneD(HCN2param, HCN2_X_params, []),
NaF=TypicalOneD(NaFparam, Na_m_params, Na_h_params, Na_s_params),
NaS=TypicalOneD(NaSparam, NaS_m_params, NaS_h_params, NaS_s_params),
Ca=TypicalOneD(Caparam, Ca_X_params, [], [], calciumPermeable=True),
SKCa=TypicalOneD(SKparam, [], [], SK_Z_params, calciumDependent=True),
BKCa=TwoD(BKparam, BK_X_params, calciumDependent=True),
)
A_C=-1,
A_vhalf=30.013e-3,
A_vslope=-7.2e-3,
B_rate=3.722e-3 * 2.14e6,
B_B=0.124 * 2.14e6,
B_C=-1,
B_vhalf=30.013e-3,
B_vslope=7.2e-3)
Na_h_params = AlphaBetaChannelParams(
A_rate=(45.013e-3 + 15.0e-3) * 0.03 * 2.14e6,
A_B=0.03 * 2.14e6,
A_C=-1,
A_vhalf=45.013e-3 + 15e-3,
A_vslope=3.5e-3,
B_rate=-(45.013e-3 + 15e-3) * 0.01 * 2.14e6,
B_B=-0.01 * 2.14e6,
B_C=-1,
B_vhalf=45.013e-3 + 15e-3,
B_vslope=-3.5e-3)
naFparams = ChannelSettings(Xpow=3, Ypow=1, Zpow=0, Erev=55.0e-3, name='NaF')
Channels = NamedDict(
'Channels',
Kdr=TypicalOneD(kDrparams, kDr_X_params, kDr_Y_params),
Kadist=TypicalOneD(KAdistparams, KAdist_m_params, KAdist_h_params),
Kaprox=TypicalOneD(KAproxparams, KAprox_m_params, KAdist_h_params),
Na=TypicalOneD(naFparams, Na_m_params, Na_h_params),
)
CaCCparam = ChannelSettings(Xpow=0, Ypow=0, Zpow=1, Erev=clrev, name='CaCC')
CaCC_Z_params = ZChannelParams(Kd=0.00183,
power=2.3,
tau=0.013,
taumax=0,
tau_power=0,
cahalf=0)
# Dictionary of "standard" channels, to create channels using a loop
# NaF doesn't fit since it uses different prototype form
# will need separate dictionary for BK
Channels = NamedDict(
'Channels',
Krp=TypicalOneD(Krpparam, Krp_X_params, Krp_Y_params),
KaF=TypicalOneD(KaFparam, KaF_X_params, KaF_Y_params),
KaS=TypicalOneD(KaSparam, KaS_X_params, KaS_Y_params),
Kir=TypicalOneD(Kirparam, Kir_X_params, []),
CaL12=TypicalOneD(CaL12param,
CaL12_X_params,
CaL12_Y_params,
CDI_Z_params,
calciumPermeable=True),
CaL13=TypicalOneD(CaL13param,
CaL13_X_params,
CaL13_Y_params,
CDI_Z_params,
calciumPermeable=True),
CaN=TypicalOneD(CaNparam,
CaN_X_params,
B_vhalf=0.0,
B_vslope=40e-3)
Krp_Y_params = TauInfMinChannelParams(T_min=0.287,
T_vdep=4.16,
T_vhalf=-0.042,
T_vslope=0.013,
SS_min=0.13,
SS_vdep=0.87,
SS_vhalf=-0.056,
SS_vslope=0.014)
Krpparam = ChannelSettings(Xpow=2, Ypow=1, Zpow=0, Erev=krev, name='Krp')
SK_Z_params = ZChannelParams(Kd=0.00035,
power=4.6,
tau=0.002,
taumax=0.0037928,
tau_power=4.3,
cahalf=0.002703)
SKparam = ChannelSettings(Xpow=0, Ypow=0, Zpow=1, Erev=krev, name='SKCa')
Channels = NamedDict('Channels',
Na=TypicalOneD(NaSparam, Na_m_params, Na_h_params),
K=TypicalOneD(KSparam, K_n_params, None),
Krp=TypicalOneD(Krpparam, Krp_X_params, Krp_Y_params),
SKCa=TypicalOneD(SKparam, [], [],
SK_Z_params,
calciumDependent=True))
BKparam = ChannelSettings(Xpow=1, Ypow=0, Zpow=0, Erev=krev, name='BKCa')
BK_X_params=[BKChannelParams(alphabeta=480, K=0.18, delta=-0.84),
BKChannelParams(alphabeta=280, K=0.011, delta=-1.0)]
#These CDI params can be used with every channel, make ZpowCDI=2
#If ZpowCDI=0 the CDI will not be used, power=-4 is to transform
#(Ca/Kd)^pow/(1+(Ca/Kd)^pow) to 1/(1+(ca/Kd)^-pow)
CDI_Z_params = ZChannelParams(Kd = 0.12e-3,
power = -4,
tau = 142e-3)
#Dictionary of "standard" channels, to create channels using a loop
#NaF doesn't fit since it uses different prototype form
#will need separate dictionary for BK
Channels = NamedDict(
'Channels',
Krp = TypicalOneD(Krpparam, Krp_X_params,Krp_Y_params),
KaF = TypicalOneD(KaFparam, KaF_X_params, KaF_Y_params),
KaS = TypicalOneD(KaSparam, KaS_X_params, KaS_Y_params),
Kir = TypicalOneD(Kirparam, Kir_X_params, []),
#CaL12 = TypicalOneD(CaL12param,CaL12_X_params, CaL12_Y_params, CDI_Z_params, calciumPermeable=True),
#CaL13 = TypicalOneD(CaL13param, CaL13_X_params,CaL13_Y_params, CDI_Z_params, calciumPermeable=True),
#CaN = TypicalOneD(CaNparam, CaN_X_params, CaN_Y_params, CDI_Z_params, calciumPermeable=True),
#CaR = TypicalOneD(CaRparam, CaR_X_params, CaR_Y_params, CDI_Z_params, calciumPermeable=True),
#CaT = TypicalOneD(CaTparam,CaT_X_params, CaT_Y_params, [], calciumPermeable=True),
#SKCa = TypicalOneD(SKparam, [], [], SK_Z_params, calciumDependent=True),
NaF = TypicalOneD(NaFparam, Na_m_params, Na_h_params),
#BKCa = TwoD(BKparam, BK_X_params, calciumDependent=True),
)
B_vslope=80e-3)
KSparam = ChannelSettings(Xpow=4, Ypow=0, Zpow=0, Erev=krev, name='K')
Krp_X_params = AlphaBetaChannelParams(A_rate=16,
A_B=0,
A_C=0.0,
A_vhalf=0,
A_vslope=-20e-3,
B_rate=2.4,
B_B=0.0,
B_C=0.0,
B_vhalf=0.0,
B_vslope=40e-3)
Krp_Y_params = TauInfMinChannelParams(T_min=0.287,
T_vdep=4.16,
T_vhalf=-0.042,
T_vslope=0.013,
SS_min=0.13,
SS_vdep=0.87,
SS_vhalf=-0.056,
SS_vslope=0.014)
Krpparam = ChannelSettings(Xpow=2, Ypow=1, Zpow=0, Erev=krev, name='Krp')
Channels = NamedDict('Channels',
Na=TypicalOneD(NaSparam, Na_m_params, Na_h_params),
K=TypicalOneD(KSparam, K_n_params, None),
Krp=TypicalOneD(Krpparam, Krp_X_params, Krp_Y_params))
Ka_X_params = TauInfMinChannelParams(T_min=1e-3,
T_vdep=1e-3,
T_vhalf=0.07,
T_vslope=-0.013,
SS_min=0,
SS_vdep=1,
SS_vhalf=-0.045,
SS_vslope=-0.013)
Ka_Y_params = TauInfMinChannelParams(T_min=0.014,
T_vdep=0,
T_vhalf=37.0e-3,
T_vslope=5.0e-3,
SS_min=0,
SS_vdep=1,
SS_vhalf=-0.077,
SS_vslope=0.008)
Kaparam = ChannelSettings(Xpow=4, Ypow=1, Zpow=0, Erev=carev, name='Ka')
#Dictionary of "standard" channels, to create channels using a loop
#NaF doesn't fit since it uses different prototype form
#will need separate dictionary for BK
Channels = NamedDict(
'Channels',
Ka=TypicalOneD(Kaparam, Ka_X_params, Ka_Y_params),
Kv13=TypicalOneD(Kv13param, Kv13_X_params, []),
Kv3132=TypicalOneD(Kv3132param, Kv3132_X_params, []),
NaF=TypicalOneD(NaFparam, NaF_X_params, NaF_Y_params),
)
A_C=-1.0,
A_vhalf=0.11,
A_vslope=17e-3,
B_rate=20,
B_B=0,
B_C=0.0,
B_vhalf=0.0,
B_vslope=-30.0e-3)
#Dictionary of "standard" channels, to create channels using a loop
#NaF doesn't fit since it uses different prototype form
#will need separate dictionary for BK
Channels = NamedDict(
'Channels',
KaF=TypicalOneD(KaFparam, KaF_X_params, KaF_Y_params),
KaS=TypicalOneD(KaSparam, KaS_X_params, KaS_Y_params),
Kir=TypicalOneD(Kirparam, Kir_X_params, []),
CaL12=TypicalOneD(CaL12param,
CaL12_X_params,
CaL12_Y_params,
calciumPermeable=True),
CaL13=TypicalOneD(CaL13param,
CaL13_X_params,
CaL13_Y_params,
calciumPermeable=True),
CaR=TypicalOneD(CaRparam,
CaR_X_params,
CaR_Y_params,
calciumPermeable=True),
NaF=TypicalOneD(NaFparam, Na_m_params, Na_h_params),
Na_h_params = AlphaBetaChannelParams(A_rate=70,
A_B=0.0,
A_C=0.0,
A_vhalf=0.0 - EREST_ACT,
A_vslope=0.02,
B_rate=1000.0,
B_B=0.0,
B_C=1.0,
B_vhalf=-30e-3 - EREST_ACT,
B_vslope=-0.01)
NaSparam = ChannelSettings(Xpow=3, Ypow=1, Zpow=0, Erev=narev, name='Na')
K_n_params = AlphaBetaChannelParams(A_rate=-1e4 * (-10e-3 - EREST_ACT),
A_B=-1e4,
A_C=-1.0,
A_vhalf=-10e-3 - EREST_ACT,
A_vslope=-10e-3,
B_rate=0.125e3,
B_B=0.0,
B_C=0.0,
B_vhalf=0.0 - EREST_ACT,
B_vslope=80e-3)
KSparam = ChannelSettings(Xpow=4, Ypow=0, Zpow=0, Erev=krev, name='K')
Channels = NamedDict('Channels',
Na=TypicalOneD(NaSparam, Na_m_params, Na_h_params),
K=TypicalOneD(KSparam, K_n_params, None))
B_vslope=22.222e-3)
Kv3132param = ChannelSettings(Xpow=2, Ypow=0, Zpow=0, Erev=krev, name='Kv3132')
Ka_X_params = TauInfMinChannelParams(T_min=1e-3,
T_vdep=1e-3,
T_vhalf=0.07,
T_vslope=-0.013,
SS_min=0,
SS_vdep=1,
SS_vhalf=-0.045,
SS_vslope=-0.013)
Ka_Y_params = TauInfMinChannelParams(T_min=0.014,
T_vdep=0,
T_vhalf=37.0e-3,
T_vslope=5.0e-3,
SS_min=0,
SS_vdep=1,
SS_vhalf=-0.077,
SS_vslope=0.008)
Kaparam = ChannelSettings(Xpow=4, Ypow=1, Zpow=0, Erev=carev, name='Ka')
Channels = NamedDict(
'Channels',
KvF=TypicalOneD(KvFparam, KvF_X_params, KvF_Y_params),
KvS=TypicalOneD(KvSparam, KvS_X_params, KvS_Y_params),
NaF=TypicalOneD(NaFparam, NaF_X_params, NaF_Y_params),
Kv3132=TypicalOneD(Kv3132param, Kv3132_X_params, []),
)
