示例#1
0
def main():

    time_start = ph.start_timing()

    # Set print options for numpy
    np.set_printoptions(precision=3)

    # Read input
    input_parser = InputArgparser(
        description="Volumetric MRI reconstruction framework to reconstruct "
        "an isotropic, high-resolution 3D volume from multiple "
        "motion-corrected (or static) stacks of low-resolution slices.", )
    input_parser.add_dir_input()
    input_parser.add_filenames()
    input_parser.add_image_selection()
    input_parser.add_dir_output(required=True)
    input_parser.add_prefix_output(default="SRR_")
    input_parser.add_suffix_mask(default="_mask")
    input_parser.add_target_stack_index(default=0)
    input_parser.add_extra_frame_target(default=10)
    input_parser.add_isotropic_resolution(default=None)
    input_parser.add_reconstruction_space(default=None)
    input_parser.add_minimizer(default="lsmr")
    input_parser.add_iter_max(default=10)
    input_parser.add_reconstruction_type(default="TK1L2")
    input_parser.add_data_loss(default="linear")
    input_parser.add_data_loss_scale(default=1)
    input_parser.add_alpha(default=0.02  # TK1L2
                           # default=0.006  #TVL2, HuberL2
                           )
    input_parser.add_rho(default=0.5)
    input_parser.add_tv_solver(default="PD")
    input_parser.add_pd_alg_type(default="ALG2")
    input_parser.add_iterations(default=15)
    input_parser.add_subfolder_comparison()
    input_parser.add_provide_comparison(default=0)
    input_parser.add_log_script_execution(default=1)
    input_parser.add_verbose(default=0)
    args = input_parser.parse_args()
    input_parser.print_arguments(args)

    # Write script execution call
    if args.log_script_execution:
        input_parser.write_performed_script_execution(
            os.path.abspath(__file__))

    # --------------------------------Read Data--------------------------------
    ph.print_title("Read Data")

    # Neither '--dir-input' nor '--filenames' was specified
    if args.filenames is not None and args.dir_input is not None:
        raise IOError("Provide input by either '--dir-input' or '--filenames' "
                      "but not both together")

    # '--dir-input' specified
    elif args.dir_input is not None:
        data_reader = dr.ImageSlicesDirectoryReader(
            path_to_directory=args.dir_input,
            suffix_mask=args.suffix_mask,
            image_selection=args.image_selection)

    # '--filenames' specified
    elif args.filenames is not None:
        data_reader = dr.MultipleImagesReader(args.filenames,
                                              suffix_mask=args.suffix_mask)

    else:
        raise IOError("Provide input by either '--dir-input' or '--filenames'")

    if args.reconstruction_type not in ["TK1L2", "TVL2", "HuberL2"]:
        raise IOError("Reconstruction type unknown")

    data_reader.read_data()
    stacks = data_reader.get_data()
    ph.print_info("%d input stacks read for further processing" % len(stacks))

    # Reconstruction space is given isotropically resampled target stack
    if args.reconstruction_space is None:
        recon0 = \
            stacks[args.target_stack_index].get_isotropically_resampled_stack(
                resolution=args.isotropic_resolution,
                extra_frame=args.extra_frame_target)

    # Reconstruction space was provided by user
    else:
        recon0 = st.Stack.from_filename(args.reconstruction_space,
                                        extract_slices=False)

        # Change resolution for isotropic resolution if provided by user
        if args.isotropic_resolution is not None:
            recon0 = recon0.get_isotropically_resampled_stack(
                args.isotropic_resolution)

        # Use image information of selected target stack as recon0 serves
        # as initial value for reconstruction
        recon0 = \
            stacks[args.target_stack_index].get_resampled_stack(recon0.sitk)
        recon0 = recon0.get_stack_multiplied_with_mask()

    if args.reconstruction_type in ["TVL2", "HuberL2"]:
        ph.print_title("Compute Initial value for %s" %
                       args.reconstruction_type)
    SRR0 = tk.TikhonovSolver(
        stacks=stacks,
        reconstruction=recon0,
        alpha=args.alpha,
        iter_max=args.iter_max,
        reg_type="TK1",
        minimizer=args.minimizer,
        data_loss=args.data_loss,
        data_loss_scale=args.data_loss_scale,
        # verbose=args.verbose,
    )
    SRR0.run()

    recon = SRR0.get_reconstruction()
    recon.set_filename(SRR0.get_setting_specific_filename(args.prefix_output))
    recon.write(args.dir_output)

    # List to store SRRs
    recons = []
    for i in range(0, len(stacks)):
        recons.append(stacks[i])
    recons.insert(0, recon)

    if args.reconstruction_type in ["TVL2", "HuberL2"]:
        ph.print_title("Compute %s reconstruction" % args.reconstruction_type)
        if args.tv_solver == "ADMM":
            SRR = admm.ADMMSolver(
                stacks=stacks,
                reconstruction=st.Stack.from_stack(SRR0.get_reconstruction()),
                minimizer=args.minimizer,
                alpha=args.alpha,
                iter_max=args.iter_max,
                rho=args.rho,
                data_loss=args.data_loss,
                iterations=args.iterations,
                verbose=args.verbose,
            )
            SRR.run()
            recon = SRR.get_reconstruction()
            recon.set_filename(
                SRR.get_setting_specific_filename(args.prefix_output))
            recons.insert(0, recon)

            recon.write(args.dir_output)

        else:

            SRR = pd.PrimalDualSolver(
                stacks=stacks,
                reconstruction=st.Stack.from_stack(SRR0.get_reconstruction()),
                minimizer=args.minimizer,
                alpha=args.alpha,
                iter_max=args.iter_max,
                iterations=args.iterations,
                alg_type=args.pd_alg_type,
                reg_type="TV"
                if args.reconstruction_type == "TVL2" else "huber",
                data_loss=args.data_loss,
                verbose=args.verbose,
            )
            SRR.run()
            recon = SRR.get_reconstruction()
            recon.set_filename(
                SRR.get_setting_specific_filename(args.prefix_output))
            recons.insert(0, recon)

            recon.write(args.dir_output)

    if args.verbose and not args.provide_comparison:
        sitkh.show_stacks(recons)

    # Show SRR together with linearly resampled input data.
    # Additionally, a script is generated to open files
    if args.provide_comparison:
        sitkh.show_stacks(
            recons,
            show_comparison_file=args.provide_comparison,
            dir_output=os.path.join(args.dir_output,
                                    args.subfolder_comparison),
        )

    ph.print_line_separator()

    elapsed_time = ph.stop_timing(time_start)
    ph.print_title("Summary")
    print("Computational Time for Volumetric Reconstruction: %s" %
          (elapsed_time))

    return 0
示例#2
0
def main():

    input_parser = InputArgparser(
        description="Simulate stacks from obtained reconstruction. "
        "Script simulates/projects the slices at estimated positions "
        "within reconstructed volume. Ideally, if motion correction was "
        "correct, the resulting stack of such obtained projected slices, "
        "corresponds to the originally acquired (motion corrupted) data.",
    )
    input_parser.add_dir_input(required=True)
    input_parser.add_reconstruction(required=True)
    input_parser.add_dir_output(required=True)
    input_parser.add_suffix_mask(default="_mask")
    input_parser.add_prefix_output(default="Simulated_")
    input_parser.add_option(
        option_string="--copy-data",
        type=int,
        help="Turn on/off copying of original data (including masks) to "
        "output folder.",
        default=0)
    input_parser.add_option(
        option_string="--reconstruction-mask",
        type=str,
        help="If given, reconstruction image mask is propagated to "
        "simulated stack(s) of slices as well",
        default=None)
    input_parser.add_interpolator(
        option_string="--interpolator-mask",
        help="Choose the interpolator type to propagate the reconstruction "
        "mask (%s)." % (INTERPOLATOR_TYPES),
        default="NearestNeighbor")
    input_parser.add_verbose(default=0)

    args = input_parser.parse_args()
    input_parser.print_arguments(args)

    if args.interpolator_mask not in ALLOWED_INTERPOLATORS:
        raise IOError(
            "Unknown interpolator provided. Possible choices are %s" % (
                INTERPOLATOR_TYPES))

    # Read motion corrected data
    data_reader = dr.ImageSlicesDirectoryReader(
        path_to_directory=args.dir_input,
        suffix_mask=args.suffix_mask)
    data_reader.read_data()
    stacks = data_reader.get_data()

    reconstruction = st.Stack.from_filename(
        args.reconstruction, args.reconstruction_mask, extract_slices=False)

    linear_operators = lin_op.LinearOperators()

    for i, stack in enumerate(stacks):

        # initialize image data array(s)
        nda = np.zeros_like(sitk.GetArrayFromImage(stack.sitk))

        if args.reconstruction_mask:
            nda_mask = np.zeros_like(sitk.GetArrayFromImage(stack.sitk_mask))

        # Simulate slices at estimated positions within reconstructed volume
        simulated_slices = [
            linear_operators.A(
                reconstruction, s, interpolator_mask=args.interpolator_mask)
            for s in stack.get_slices()
        ]

        # Fill stack information "as if slice was acquired consecutively"
        # Therefore, simulated stack slices correspond to acquired slices
        # (in case motion correction was correct)
        for j, simulated_slice in enumerate(simulated_slices):
            nda[j, :, :] = sitk.GetArrayFromImage(simulated_slice.sitk)

            if args.reconstruction_mask:
                nda_mask[j, :, :] = sitk.GetArrayFromImage(
                    simulated_slice.sitk_mask)

        # Create nifti image with same image header as original stack
        simulated_stack_sitk = sitk.GetImageFromArray(nda)
        simulated_stack_sitk.CopyInformation(stack.sitk)

        if args.reconstruction_mask:
            simulated_stack_sitk_mask = sitk.GetImageFromArray(nda_mask)
            simulated_stack_sitk_mask.CopyInformation(stack.sitk_mask)
        else:
            simulated_stack_sitk_mask = None

        simulated_stack = st.Stack.from_sitk_image(
            image_sitk=simulated_stack_sitk,
            image_sitk_mask=simulated_stack_sitk_mask,
            filename=args.prefix_output + stack.get_filename(),
            extract_slices=False)

        if args.verbose:
            sitkh.show_stacks([
                stack, simulated_stack],
                segmentation=simulated_stack
                if args.reconstruction_mask else None)

        simulated_stack.write(
            args.dir_output,
            write_mask=True,
            write_slices=False,
            suffix_mask=args.suffix_mask)

        if args.copy_data:
            stack.write(
                args.dir_output,
                write_mask=True,
                write_slices=False,
                suffix_mask=args.suffix_mask)

    return 0
示例#3
0
def main():

    time_start = ph.start_timing()

    # Set print options for numpy
    np.set_printoptions(precision=3)

    # Read input
    input_parser = InputArgparser(
        description="Volumetric MRI reconstruction framework to reconstruct "
        "an isotropic, high-resolution 3D volume from multiple stacks of 2D "
        "slices with motion correction. The resolution of the computed "
        "Super-Resolution Reconstruction (SRR) is given by the in-plane "
        "spacing of the selected target stack. A region of interest can be "
        "specified by providing a mask for the selected target stack. Only "
        "this region will then be reconstructed by the SRR algorithm which "
        "can substantially reduce the computational time.", )
    input_parser.add_dir_input()
    input_parser.add_filenames()
    input_parser.add_dir_output(required=True)
    input_parser.add_suffix_mask(default="_mask")
    input_parser.add_target_stack_index(default=0)
    input_parser.add_search_angle(default=90)
    input_parser.add_multiresolution(default=0)
    input_parser.add_shrink_factors(default=[2, 1])
    input_parser.add_smoothing_sigmas(default=[1, 0])
    input_parser.add_sigma(default=0.9)
    input_parser.add_reconstruction_type(default="TK1L2")
    input_parser.add_iterations(default=15)
    input_parser.add_alpha(default=0.02)
    input_parser.add_alpha_first(default=0.05)
    input_parser.add_iter_max(default=10)
    input_parser.add_iter_max_first(default=5)
    input_parser.add_dilation_radius(default=3)
    input_parser.add_extra_frame_target(default=10)
    input_parser.add_bias_field_correction(default=0)
    input_parser.add_intensity_correction(default=0)
    input_parser.add_isotropic_resolution(default=None)
    input_parser.add_log_script_execution(default=1)
    input_parser.add_subfolder_motion_correction()
    input_parser.add_provide_comparison(default=0)
    input_parser.add_subfolder_comparison()
    input_parser.add_write_motion_correction(default=1)
    input_parser.add_verbose(default=0)
    input_parser.add_two_step_cycles(default=3)
    input_parser.add_use_masks_srr(default=1)
    input_parser.add_boundary_stacks(default=[10, 10, 0])
    input_parser.add_reference()
    input_parser.add_reference_mask()

    args = input_parser.parse_args()
    input_parser.print_arguments(args)

    # Write script execution call
    if args.log_script_execution:
        input_parser.write_performed_script_execution(
            os.path.abspath(__file__))

    # Use FLIRT for volume-to-volume reg. step. Otherwise, RegAladin is used.
    use_flirt_for_v2v_registration = True

    # --------------------------------Read Data--------------------------------
    ph.print_title("Read Data")

    # Neither '--dir-input' nor '--filenames' was specified
    if args.filenames is not None and args.dir_input is not None:
        raise IOError("Provide input by either '--dir-input' or '--filenames' "
                      "but not both together")

    # '--dir-input' specified
    elif args.dir_input is not None:
        data_reader = dr.ImageDirectoryReader(args.dir_input,
                                              suffix_mask=args.suffix_mask)

    # '--filenames' specified
    elif args.filenames is not None:
        data_reader = dr.MultipleImagesReader(args.filenames,
                                              suffix_mask=args.suffix_mask)

    else:
        raise IOError("Provide input by either '--dir-input' or '--filenames'")

    if len(args.boundary_stacks) is not 3:
        raise IOError(
            "Provide exactly three values for '--boundary-stacks' to define "
            "cropping in i-, j-, and k-dimension of the input stacks")

    data_reader.read_data()
    stacks = data_reader.get_data()
    ph.print_info("%d input stacks read for further processing" % len(stacks))

    if all(s.is_unity_mask() is True for s in stacks):
        ph.print_warning("No mask is provided! "
                         "Generated reconstruction space may be very big!")

    # ---------------------------Data Preprocessing---------------------------
    ph.print_title("Data Preprocessing")

    segmentation_propagator = segprop.SegmentationPropagation(
        # registration_method=regflirt.FLIRT(use_verbose=args.verbose),
        dilation_radius=args.dilation_radius,
        dilation_kernel="Ball",
    )

    data_preprocessing = dp.DataPreprocessing(
        stacks=stacks,
        segmentation_propagator=segmentation_propagator,
        use_cropping_to_mask=True,
        use_N4BiasFieldCorrector=args.bias_field_correction,
        use_intensity_correction=args.intensity_correction,
        target_stack_index=args.target_stack_index,
        boundary_i=args.boundary_stacks[0],
        boundary_j=args.boundary_stacks[1],
        boundary_k=args.boundary_stacks[2],
        unit="mm",
    )
    data_preprocessing.run()
    time_data_preprocessing = data_preprocessing.get_computational_time()

    # Get preprocessed stacks
    stacks = data_preprocessing.get_preprocessed_stacks()

    # Define reference/target stack for registration and reconstruction
    if args.reference is not None:
        reference = st.Stack.from_filename(file_path=args.reference,
                                           file_path_mask=args.reference_mask,
                                           extract_slices=False)

    else:
        reference = st.Stack.from_stack(stacks[args.target_stack_index])

    # ------------------------Volume-to-Volume Registration--------------------
    if args.two_step_cycles > 0:
        # Define search angle ranges for FLIRT in all three dimensions
        search_angles = [
            "-searchr%s -%d %d" % (x, args.search_angle, args.search_angle)
            for x in ["x", "y", "z"]
        ]
        search_angles = (" ").join(search_angles)

        if use_flirt_for_v2v_registration:
            vol_registration = regflirt.FLIRT(
                registration_type="Rigid",
                use_fixed_mask=True,
                use_moving_mask=True,
                options=search_angles,
                use_verbose=False,
            )
        else:
            vol_registration = niftyreg.RegAladin(
                registration_type="Rigid",
                use_fixed_mask=True,
                use_moving_mask=True,
                use_verbose=False,
            )
        v2vreg = pipeline.VolumeToVolumeRegistration(
            stacks=stacks,
            reference=reference,
            registration_method=vol_registration,
            verbose=args.verbose,
        )
        v2vreg.run()
        stacks = v2vreg.get_stacks()
        time_registration = v2vreg.get_computational_time()

    else:
        time_registration = ph.get_zero_time()

    # ---------------------------Create first volume---------------------------
    time_tmp = ph.start_timing()

    # Isotropic resampling to define HR target space
    ph.print_title("Reconstruction Space Generation")
    HR_volume = reference.get_isotropically_resampled_stack(
        resolution=args.isotropic_resolution)
    ph.print_info(
        "Isotropic reconstruction space with %g mm resolution is created" %
        HR_volume.sitk.GetSpacing()[0])

    if args.reference is None:
        # Create joint image mask in target space
        joint_image_mask_builder = imb.JointImageMaskBuilder(
            stacks=stacks,
            target=HR_volume,
            dilation_radius=1,
        )
        joint_image_mask_builder.run()
        HR_volume = joint_image_mask_builder.get_stack()
        ph.print_info("Isotropic reconstruction space is centered around "
                      "joint stack masks. ")

        # Crop to space defined by mask (plus extra margin)
        HR_volume = HR_volume.get_cropped_stack_based_on_mask(
            boundary_i=args.extra_frame_target,
            boundary_j=args.extra_frame_target,
            boundary_k=args.extra_frame_target,
            unit="mm",
        )

        # Scattered Data Approximation to get first estimate of HR volume
        ph.print_title("First Estimate of HR Volume")
        SDA = sda.ScatteredDataApproximation(stacks,
                                             HR_volume,
                                             sigma=args.sigma)
        SDA.run()
        HR_volume = SDA.get_reconstruction()

    time_reconstruction = ph.stop_timing(time_tmp)

    if args.verbose:
        tmp = list(stacks)
        tmp.insert(0, HR_volume)
        sitkh.show_stacks(tmp, segmentation=HR_volume)

    # ----------------Two-step Slice-to-Volume Registration SRR----------------
    SRR = tk.TikhonovSolver(
        stacks=stacks,
        reconstruction=HR_volume,
        reg_type="TK1",
        minimizer="lsmr",
        alpha=args.alpha_first,
        iter_max=args.iter_max_first,
        verbose=True,
        use_masks=args.use_masks_srr,
    )

    if args.two_step_cycles > 0:

        registration = regsitk.SimpleItkRegistration(
            moving=HR_volume,
            use_fixed_mask=True,
            use_moving_mask=True,
            use_verbose=args.verbose,
            interpolator="Linear",
            metric="Correlation",
            use_multiresolution_framework=args.multiresolution,
            shrink_factors=args.shrink_factors,
            smoothing_sigmas=args.smoothing_sigmas,
            initializer_type="SelfGEOMETRY",
            optimizer="ConjugateGradientLineSearch",
            optimizer_params={
                "learningRate": 1,
                "numberOfIterations": 100,
                "lineSearchUpperLimit": 2,
            },
            scales_estimator="Jacobian",
        )
        two_step_s2v_reg_recon = \
            pipeline.TwoStepSliceToVolumeRegistrationReconstruction(
                stacks=stacks,
                reference=HR_volume,
                registration_method=registration,
                reconstruction_method=SRR,
                cycles=args.two_step_cycles,
                alpha_range=[args.alpha_first, args.alpha],
                verbose=args.verbose,
            )
        two_step_s2v_reg_recon.run()
        HR_volume_iterations = \
            two_step_s2v_reg_recon.get_iterative_reconstructions()
        time_registration += \
            two_step_s2v_reg_recon.get_computational_time_registration()
        time_reconstruction += \
            two_step_s2v_reg_recon.get_computational_time_reconstruction()
    else:
        HR_volume_iterations = []

    # Write motion-correction results
    if args.write_motion_correction:
        for stack in stacks:
            stack.write(
                os.path.join(args.dir_output,
                             args.subfolder_motion_correction),
                write_mask=True,
                write_slices=True,
                write_transforms=True,
                suffix_mask=args.suffix_mask,
            )

    # ------------------Final Super-Resolution Reconstruction------------------
    ph.print_title("Final Super-Resolution Reconstruction")
    if args.reconstruction_type in ["TVL2", "HuberL2"]:
        SRR = pd.PrimalDualSolver(
            stacks=stacks,
            reconstruction=HR_volume,
            reg_type="TV" if args.reconstruction_type == "TVL2" else "huber",
            iterations=args.iterations,
        )
    else:
        SRR = tk.TikhonovSolver(
            stacks=stacks,
            reconstruction=HR_volume,
            reg_type="TK1" if args.reconstruction_type == "TK1L2" else "TK0",
            use_masks=args.use_masks_srr,
        )
    SRR.set_alpha(args.alpha)
    SRR.set_iter_max(args.iter_max)
    SRR.set_verbose(True)
    SRR.run()
    time_reconstruction += SRR.get_computational_time()

    elapsed_time_total = ph.stop_timing(time_start)

    # Write SRR result
    HR_volume_final = SRR.get_reconstruction()
    HR_volume_final.set_filename(SRR.get_setting_specific_filename())
    HR_volume_final.write(args.dir_output,
                          write_mask=True,
                          suffix_mask=args.suffix_mask)

    HR_volume_iterations.insert(0, HR_volume_final)
    for stack in stacks:
        HR_volume_iterations.append(stack)

    if args.verbose and not args.provide_comparison:
        sitkh.show_stacks(HR_volume_iterations, segmentation=HR_volume)
    # HR_volume_final.show()

    # Show SRR together with linearly resampled input data.
    # Additionally, a script is generated to open files
    if args.provide_comparison:
        sitkh.show_stacks(
            HR_volume_iterations,
            segmentation=HR_volume,
            show_comparison_file=args.provide_comparison,
            dir_output=os.path.join(args.dir_output,
                                    args.subfolder_comparison),
        )

    # Summary
    ph.print_title("Summary")
    print("Computational Time for Data Preprocessing: %s" %
          (time_data_preprocessing))
    print("Computational Time for Registrations: %s" % (time_registration))
    print("Computational Time for Reconstructions: %s" % (time_reconstruction))
    print("Computational Time for Entire Reconstruction Pipeline: %s" %
          (elapsed_time_total))

    ph.print_line_separator()

    return 0
示例#4
0
def main():

    time_start = ph.start_timing()

    # Set print options for numpy
    np.set_printoptions(precision=3)

    # Read input
    input_parser = InputArgparser(
        description="Script to study reconstruction parameters and their "
        "impact on the volumetric reconstruction quality.",
    )
    input_parser.add_dir_input()
    input_parser.add_filenames()
    input_parser.add_image_selection()
    input_parser.add_dir_output(required=True)
    input_parser.add_suffix_mask(default="_mask")
    input_parser.add_reconstruction_space()
    input_parser.add_reference(
        help="Path to reference NIfTI image file. If given the volumetric "
        "reconstructed is performed in this physical space. "
        "Either a reconstruction space or a reference must be provided",
        required=False)
    input_parser.add_reference_mask(default=None)
    input_parser.add_study_name()
    input_parser.add_reconstruction_type(default="TK1L2")
    input_parser.add_measures(default=["PSNR", "RMSE", "SSIM", "NCC", "NMI"])
    input_parser.add_tv_solver(default="PD")
    input_parser.add_iterations(default=50)
    input_parser.add_rho(default=0.1)
    input_parser.add_iter_max(default=10)
    input_parser.add_minimizer(default="lsmr")
    input_parser.add_alpha(default=0.01)
    input_parser.add_data_loss(default="linear")
    input_parser.add_data_loss_scale(default=1)
    input_parser.add_log_script_execution(default=1)
    input_parser.add_verbose(default=1)

    # Range for parameter sweeps
    input_parser.add_alpha_range(default=[0.001, 0.05, 20])  # TK1L2
    # input_parser.add_alpha_range(default=[0.001, 0.003, 10])  # TVL2, HuberL2
    input_parser.add_data_losses(
        # default=["linear", "arctan"]
    )
    input_parser.add_data_loss_scale_range(
        # default=[0.1, 1.5, 2]
    )

    args = input_parser.parse_args()
    input_parser.print_arguments(args)

    if args.reference is None and args.reconstruction_space is None:
        raise IOError("Either reference (--reference) or reconstruction space "
                      "(--reconstruction-space) must be provided.")

    # Write script execution call
    if args.log_script_execution:
        input_parser.write_performed_script_execution(
            os.path.abspath(__file__))

    # --------------------------------Read Data--------------------------------
    ph.print_title("Read Data")

    # Neither '--dir-input' nor '--filenames' was specified
    if args.filenames is not None and args.dir_input is not None:
        raise IOError(
            "Provide input by either '--dir-input' or '--filenames' "
            "but not both together")

    # '--dir-input' specified
    elif args.dir_input is not None:
        data_reader = dr.ImageSlicesDirectoryReader(
            path_to_directory=args.dir_input,
            suffix_mask=args.suffix_mask,
            image_selection=args.image_selection)

    # '--filenames' specified
    elif args.filenames is not None:
        data_reader = dr.MultipleImagesReader(
            args.filenames, suffix_mask=args.suffix_mask)

    else:
        raise IOError(
            "Provide input by either '--dir-input' or '--filenames'")

    data_reader.read_data()
    stacks = data_reader.get_data()
    ph.print_info("%d input stacks read for further processing" % len(stacks))

    if args.reference is not None:
        reference = st.Stack.from_filename(
            file_path=args.reference,
            file_path_mask=args.reference_mask,
            extract_slices=False)

        reconstruction_space = stacks[0].get_resampled_stack(reference.sitk)
        reconstruction_space = \
            reconstruction_space.get_stack_multiplied_with_mask()
        x_ref = sitk.GetArrayFromImage(reference.sitk).flatten()
        x_ref_mask = sitk.GetArrayFromImage(reference.sitk_mask).flatten()

    else:
        reconstruction_space = st.Stack.from_filename(
            file_path=args.reconstruction_space,
            extract_slices=False)
        reconstruction_space = stacks[0].get_resampled_stack(
            reconstruction_space.sitk)
        reconstruction_space = \
            reconstruction_space.get_stack_multiplied_with_mask()
        x_ref = None
        x_ref_mask = None

    # ----------------------------Set Up Parameters----------------------------
    parameters = {}
    parameters["alpha"] = np.linspace(
        args.alpha_range[0], args.alpha_range[1], int(args.alpha_range[2]))
    if args.data_losses is not None:
        parameters["data_loss"] = args.data_losses
    if args.data_loss_scale_range is not None:
        parameters["data_loss_scale"] = np.linspace(
            args.data_loss_scale_range[0],
            args.data_loss_scale_range[1],
            int(args.data_loss_scale_range[2]))

    # --------------------------Set Up Parameter Study-------------------------
    if args.study_name is None:
        name = args.reconstruction_type
    else:
        name = args.study_name

    reconstruction_info = {
        "shape": reconstruction_space.sitk.GetSize()[::-1],
        "origin": reconstruction_space.sitk.GetOrigin(),
        "spacing": reconstruction_space.sitk.GetSpacing(),
        "direction": reconstruction_space.sitk.GetDirection(),
    }

    # Create Tikhonov solver from which all information can be extracted
    # (also for other reconstruction types)
    tmp = tk.TikhonovSolver(
        stacks=stacks,
        reconstruction=reconstruction_space,
        alpha=args.alpha,
        iter_max=args.iter_max,
        data_loss=args.data_loss,
        data_loss_scale=args.data_loss_scale,
        reg_type="TK1",
        minimizer=args.minimizer,
        verbose=args.verbose,
    )
    solver = tmp.get_solver()

    parameter_study_interface = \
        deconv_interface.DeconvolutionParameterStudyInterface(
            A=solver.get_A(),
            A_adj=solver.get_A_adj(),
            D=solver.get_B(),
            D_adj=solver.get_B_adj(),
            b=solver.get_b(),
            x0=solver.get_x0(),
            alpha=solver.get_alpha(),
            x_scale=solver.get_x_scale(),
            data_loss=solver.get_data_loss(),
            data_loss_scale=solver.get_data_loss_scale(),
            iter_max=solver.get_iter_max(),
            minimizer=solver.get_minimizer(),
            iterations=args.iterations,
            measures=args.measures,
            dimension=3,
            L2=16./reconstruction_space.sitk.GetSpacing()[0]**2,
            reconstruction_type=args.reconstruction_type,
            rho=args.rho,
            dir_output=args.dir_output,
            parameters=parameters,
            name=name,
            reconstruction_info=reconstruction_info,
            x_ref=x_ref,
            x_ref_mask=x_ref_mask,
            tv_solver=args.tv_solver,
            verbose=args.verbose,
        )
    parameter_study_interface.set_up_parameter_study()
    parameter_study = parameter_study_interface.get_parameter_study()

    # Run parameter study
    parameter_study.run()

    print("\nComputational time for Deconvolution Parameter Study %s: %s" %
          (name, parameter_study.get_computational_time()))

    return 0
def main():

    input_parser = InputArgparser(
        description="Script to show the evaluated similarity between "
        "simulated stack from obtained reconstruction and original stack. "
        "This function takes the result of "
        "evaluate_simulated_stack_similarity.py as input. "
        "Provide --dir-output in order to save the results."
    )
    input_parser.add_dir_input(required=True)
    input_parser.add_dir_output(required=False)

    args = input_parser.parse_args()
    input_parser.print_arguments(args)

    if not ph.directory_exists(args.dir_input):
        raise exceptions.DirectoryNotExistent(args.dir_input)

    # --------------------------------Read Data--------------------------------
    pattern = "Similarity_(" + REGEX_FILENAMES + ")[.]txt"
    p = re.compile(pattern)
    dic_filenames = {
        p.match(f).group(1): p.match(f).group(0)
        for f in os.listdir(args.dir_input) if p.match(f)
    }

    dic_stacks = {}
    for filename in dic_filenames.keys():
        path_to_file = os.path.join(args.dir_input, dic_filenames[filename])

        # Extract evaluated measures written as header in second line
        measures = open(path_to_file).readlines()[1]
        measures = re.sub("#\t", "", measures)
        measures = re.sub("\n", "", measures)
        measures = measures.split("\t")

        # Extract errors
        similarities = np.loadtxt(path_to_file, skiprows=2)

        # Build dictionary holding all similarity information for stack
        dic_stack_similarity = {
            measures[i]: similarities[:, i] for i in range(len(measures))
        }
        # dic_stack_similarity["measures"] = measures

        # Store information of to dictionary
        dic_stacks[filename] = dic_stack_similarity

    # -----------Visualize stacks individually per similarity measure----------
    ctr = [0]
    N_stacks = len(dic_stacks)
    N_measures = len(measures)
    rows = 2 if N_measures < 6 else 3
    filenames = natsorted(dic_stacks.keys(), key=lambda y: y.lower())

    for i, filename in enumerate(filenames):
        fig = plt.figure(ph.add_one(ctr))
        fig.clf()

        for m, measure in enumerate(measures):
            ax = plt.subplot(rows, np.ceil(N_measures/float(rows)), m+1)

            y = dic_stacks[filename][measure]
            x = range(1, y.size+1)
            lines = plt.plot(x, y)
            line = lines[0]
            line.set_linestyle("")
            line.set_marker(ph.MARKERS[0])
            # line.set_markerfacecolor("w")
            plt.xlabel("Slice")
            plt.ylabel(measure)
            ax.set_xticks(x)

            if measure in ["SSIM", "NCC"]:
                ax.set_ylim([0, 1])

        plt.suptitle(filename)
        try:
            # Open windows (and also save them) in full screen
            manager = plt.get_current_fig_manager()
            manager.full_screen_toggle()
        except:
            pass
        plt.show(block=False)
        if args.dir_output is not None:
            filename = "Similarity_%s.pdf" % filename
            ph.save_fig(fig, args.dir_output, filename)

    # -----------All in one (meaningful in case of similar scaling)----------
    fig = plt.figure(ph.add_one(ctr))
    fig.clf()
    data = {}
    for m, measure in enumerate(measures):
        for i, filename in enumerate(filenames):
            similarities = dic_stacks[filename][measure]
            labels = [filename] * similarities.size
            if m == 0:
                if "Stack" not in data.keys():
                    data["Stack"] = labels
                else:
                    data["Stack"] = np.concatenate((data["Stack"], labels))
            if measure not in data.keys():
                data[measure] = similarities
            else:
                data[measure] = np.concatenate(
                    (data[measure], similarities))
    df_melt = pd.DataFrame(data).melt(
        id_vars="Stack",
        var_name="",
        value_name=" ",
        value_vars=measures,
    )
    ax = plt.subplot(1, 1, 1)
    b = sns.boxplot(
        data=df_melt,
        hue="Stack",  # different colors for different "Stack"
        x="",
        y=" ",
        order=measures,
    )
    ax.set_axisbelow(True)
    try:
        # Open windows (and also save them) in full screen
        manager = plt.get_current_fig_manager()
        manager.full_screen_toggle()
    except:
        pass
    plt.show(block=False)
    if args.dir_output is not None:
        filename = "Boxplot.pdf"
        ph.save_fig(fig, args.dir_output, filename)

    # # -------------Boxplot: Plot individual similarity measures v1----------
    # for m, measure in enumerate(measures):
    #     fig = plt.figure(ph.add_one(ctr))
    #     fig.clf()
    #     data = {}
    #     for i, filename in enumerate(filenames):
    #         similarities = dic_stacks[filename][measure]
    #         labels = [filename] * similarities.size
    #         if "Stack" not in data.keys():
    #             data["Stack"] = labels
    #         else:
    #             data["Stack"] = np.concatenate((data["Stack"], labels))
    #         if measure not in data.keys():
    #             data[measure] = similarities
    #         else:
    #             data[measure] = np.concatenate(
    #                 (data[measure], similarities))
    #     df_melt = pd.DataFrame(data).melt(
    #         id_vars="Stack",
    #         var_name="",
    #         value_name=measure,
    #     )
    #     ax = plt.subplot(1, 1, 1)
    #     b = sns.boxplot(
    #         data=df_melt,
    #         hue="Stack",  # different colors for different "Stack"
    #         x="",
    #         y=measure,
    #     )
    #     ax.set_axisbelow(True)
    #     plt.show(block=False)

    # # -------------Boxplot: Plot individual similarity measures v2----------
    # for m, measure in enumerate(measures):
    #     fig = plt.figure(ph.add_one(ctr))
    #     fig.clf()
    #     data = {}
    #     for i, filename in enumerate(filenames):
    #         similarities = dic_stacks[filename][measure]
    #         labels = [filename] * len(filenames)
    #         if filename not in data.keys():
    #             data[filename] = similarities
    #         else:
    #             data[filename] = np.concatenate(
    #                 (data[filename], similarities))
    #     for filename in filenames:
    #         data[filename] = pd.Series(data[filename])
    #     df = pd.DataFrame(data)
    #     df_melt = df.melt(
    #         var_name="",
    #         value_name=measure,
    #         value_vars=filenames,
    #     )
    #     ax = plt.subplot(1, 1, 1)
    #     b = sns.boxplot(
    #         data=df_melt,
    #         x="",
    #         y=measure,
    #         order=filenames,
    #     )
    #     ax.set_axisbelow(True)
    #     plt.show(block=False)

    return 0
示例#6
0
def main():

    time_start = ph.start_timing()

    np.set_printoptions(precision=3)

    input_parser = InputArgparser(
        description="Register an obtained reconstruction (moving) "
        "to a template image/space (fixed) using rigid registration. "
        "The resulting registration can optionally be applied to previously "
        "obtained motion correction slice transforms so that a volumetric "
        "reconstruction is possible in the (standard anatomical) space "
        "defined by the fixed.", )
    input_parser.add_fixed(required=True)
    input_parser.add_moving(
        required=True,
        nargs="+",
        help="Specify moving image to be warped to fixed space. "
        "If multiple images are provided, all images will be transformed "
        "uniformly according to the registration obtained for the first one.")
    input_parser.add_dir_output(required=True)
    input_parser.add_dir_input()
    input_parser.add_suffix_mask(default="_mask")
    input_parser.add_search_angle(default=180)
    input_parser.add_option(
        option_string="--transform-only",
        type=int,
        help="Turn on/off functionality to transform moving image(s) to fixed "
        "image only, i.e. no resampling to fixed image space",
        default=0)
    input_parser.add_option(
        option_string="--write-transform",
        type=int,
        help="Turn on/off functionality to write registration transform",
        default=0)
    input_parser.add_verbose(default=0)

    args = input_parser.parse_args()
    input_parser.print_arguments(args)

    use_reg_aladin_for_refinement = True

    # --------------------------------Read Data--------------------------------
    ph.print_title("Read Data")
    data_reader = dr.MultipleImagesReader(args.moving, suffix_mask="_mask")
    data_reader.read_data()
    moving = data_reader.get_data()

    data_reader = dr.MultipleImagesReader([args.fixed], suffix_mask="_mask")
    data_reader.read_data()
    fixed = data_reader.get_data()[0]

    # -------------------Register Reconstruction to Template-------------------
    ph.print_title("Register Reconstruction to Template")

    # Define search angle ranges for FLIRT in all three dimensions
    search_angles = [
        "-searchr%s -%d %d" % (x, args.search_angle, args.search_angle)
        for x in ["x", "y", "z"]
    ]
    search_angles = (" ").join(search_angles)
    options_args = []
    options_args.append(search_angles)
    # cost = "mutualinfo"
    # options_args.append("-searchcost %s -cost %s" % (cost, cost))
    registration = regflirt.FLIRT(
        fixed=moving[0],
        moving=fixed,
        # use_fixed_mask=True,
        # use_moving_mask=True,  # moving mask only seems to work for SB cases
        registration_type="Rigid",
        use_verbose=False,
        options=(" ").join(options_args),
    )
    ph.print_info("Run Registration (FLIRT) ... ", newline=False)
    registration.run()
    print("done")
    transform_sitk = registration.get_registration_transform_sitk()

    if args.write_transform:
        path_to_transform = os.path.join(args.dir_output,
                                         "registration_transform_sitk.txt")
        sitk.WriteTransform(transform_sitk, path_to_transform)

    # Apply rigidly transform to align reconstruction (moving) with template
    # (fixed)
    for m in moving:
        m.update_motion_correction(transform_sitk)

        # Additionally, use RegAladin for more accurate alignment
        # Rationale: FLIRT has better capture range, but RegAladin seems to
        # find better alignment once it is within its capture range.
        if use_reg_aladin_for_refinement:
            registration = niftyreg.RegAladin(
                fixed=m,
                use_fixed_mask=True,
                moving=fixed,
                registration_type="Rigid",
                use_verbose=False,
            )
            ph.print_info("Run Registration (RegAladin) ... ", newline=False)
            registration.run()
            print("done")
            transform2_sitk = registration.get_registration_transform_sitk()
            m.update_motion_correction(transform2_sitk)
            transform_sitk = sitkh.get_composite_sitk_affine_transform(
                transform2_sitk, transform_sitk)

    if args.transform_only:
        for m in moving:
            m.write(args.dir_output, write_mask=False)
        ph.exit()

    # Resample reconstruction (moving) to template space (fixed)
    warped_moving = [
        m.get_resampled_stack(fixed.sitk, interpolator="Linear")
        for m in moving
    ]

    for wm in warped_moving:
        wm.set_filename(wm.get_filename() + "ResamplingToTemplateSpace")

        if args.verbose:
            sitkh.show_stacks([fixed, wm], segmentation=fixed)

        # Write resampled reconstruction (moving)
        wm.write(args.dir_output, write_mask=False)

    if args.dir_input is not None:
        data_reader = dr.ImageSlicesDirectoryReader(
            path_to_directory=args.dir_input, suffix_mask=args.suffix_mask)
        data_reader.read_data()
        stacks = data_reader.get_data()

        for i, stack in enumerate(stacks):
            stack.update_motion_correction(transform_sitk)
            ph.print_info("Stack %d/%d: All slice transforms updated" %
                          (i + 1, len(stacks)))

            # Write transformed slices
            stack.write(
                os.path.join(args.dir_output, "motion_correction"),
                write_mask=True,
                write_slices=True,
                write_transforms=True,
                suffix_mask=args.suffix_mask,
            )

    elapsed_time_total = ph.stop_timing(time_start)

    # Summary
    ph.print_title("Summary")
    print("Computational Time: %s" % (elapsed_time_total))

    return 0
def main():

    time_start = ph.start_timing()

    np.set_printoptions(precision=3)

    input_parser = InputArgparser(
        description="Run reconstruction pipeline including "
        "(i) preprocessing (bias field correction + intensity correction), "
        "(ii) volumetric reconstruction in subject space, "
        "and (iii) volumetric reconstruction in template space.",
    )
    input_parser.add_dir_input(required=True)
    input_parser.add_dir_mask(required=True)
    input_parser.add_dir_output(required=True)
    input_parser.add_suffix_mask(default="_mask")
    input_parser.add_target_stack(required=False)
    input_parser.add_alpha(default=0.01)
    input_parser.add_verbose(default=0)
    input_parser.add_gestational_age(required=False)
    input_parser.add_prefix_output(default="")
    input_parser.add_search_angle(default=180)
    input_parser.add_multiresolution(default=0)
    input_parser.add_log_script_execution(default=1)
    input_parser.add_dir_input_templates(default=DIR_TEMPLATES)
    input_parser.add_isotropic_resolution()
    input_parser.add_reference()
    input_parser.add_reference_mask()
    input_parser.add_bias_field_correction(default=1)
    input_parser.add_intensity_correction(default=1)
    input_parser.add_iter_max(default=10)
    input_parser.add_two_step_cycles(default=3)
    input_parser.add_option(
        option_string="--run-recon-subject-space",
        type=int,
        help="Turn on/off reconstruction in subject space",
        default=1)
    input_parser.add_option(
        option_string="--run-recon-template-space",
        type=int,
        help="Turn on/off reconstruction in template space",
        default=1)
    input_parser.add_option(
        option_string="--run-data-vs-simulated-data",
        type=int,
        help="Turn on/off comparison of data vs data simulated from the "
        "obtained volumetric reconstruction",
        default=1)
    input_parser.add_outlier_rejection(default=0)
    input_parser.add_use_robust_registration(default=0)

    args = input_parser.parse_args()
    input_parser.print_arguments(args)

    # Write script execution call
    if args.log_script_execution:
        input_parser.write_performed_script_execution(
            os.path.abspath(__file__))

    dir_output_recon_subject_space = os.path.join(
        args.dir_output, "recon_subject_space")
    dir_output_recon_template_space = os.path.join(
        args.dir_output, "recon_template_space")
    dir_output_data_vs_simulatd_data = os.path.join(
        args.dir_output, "data_vs_simulated_data")

#    if args.run_recon_template_space and args.gestational_age is None:
#        raise IOError("Gestational age must be set in order to pick the "
#                      "right template")

    # get input stack names
    files = os.listdir(args.dir_input)
    input_files = []
    mask_files  = []
    for file in files:
        if (".nii" in file):
            input_files.append("{0:}/{1:}".format(args.dir_input, file))
            file_prefix = file[:-7] if (".nii.gz" in file) else file[:-4]
            mask_name = "{0:}/{1:}.nii.gz".format(args.dir_mask, file_prefix)
            if(not os.path.isfile(mask_name)):
                mask_name = "{0:}/{1:}.nii".format(args.dir_mask, file_prefix)
            assert(os.path.isfile(mask_name))
            mask_files.append(mask_name)


    if args.target_stack is None:
        target_stack = input_files[0]
    else:
        target_stack = input_files

    if args.run_recon_subject_space:

        target_stack_index = input_files.index(target_stack)

        cmd_args = []
        cmd_args.append("--filenames %s" % (" ").join(input_files))
        cmd_args.append("--filenames-masks %s" % (" ").join(mask_files))
        cmd_args.append("--multiresolution %d" % args.multiresolution)
        cmd_args.append("--target-stack-index %d" % target_stack_index)
        cmd_args.append("--dir-output %s" % dir_output_recon_subject_space)
#        cmd_args.append("--suffix-mask %s" % args.suffix_mask)
        cmd_args.append("--intensity-correction %d" %
                        args.intensity_correction)
        cmd_args.append("--alpha %s" % args.alpha)
        cmd_args.append("--iter-max %d" % args.iter_max)
        cmd_args.append("--two-step-cycles %d" % args.two_step_cycles)
        cmd_args.append("--outlier-rejection %d" %
                        args.outlier_rejection)
        cmd_args.append("--use-robust-registration %d" %
                        args.use_robust_registration)
        cmd_args.append("--verbose %d" % args.verbose)
        if args.isotropic_resolution is not None:
            cmd_args.append("--isotropic-resolution %f" %
                            args.isotropic_resolution)
        if args.reference is not None:
            cmd_args.append("--reference %s" % args.reference)
        if args.reference_mask is not None:
            cmd_args.append("--reference-mask %s" % args.reference_mask)
        cmd = "niftymic_reconstruct_volume %s" % (" ").join(cmd_args)
        time_start_volrec = ph.start_timing()
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            raise RuntimeError("Reconstruction in subject space failed")
        elapsed_time_volrec = ph.stop_timing(time_start_volrec)
    else:
        elapsed_time_volrec = ph.get_zero_time()

    if args.run_recon_template_space:
        # register recon to template space
        pattern = "[a-zA-Z0-9_]+(stacks)[a-zA-Z0-9_]+(.nii.gz)"
        p = re.compile(pattern)
        reconstruction = [
            os.path.join(
                dir_output_recon_subject_space, p.match(f).group(0))
            for f in os.listdir(dir_output_recon_subject_space)
            if p.match(f)][0]
            
        if('mask_manual' in args.dir_output):
            # find the corresponding template by volume matching
            reconstruction_mask = reconstruction
            if(not ("_mask" in reconstruction)):
                reconstruction_mask = ph.append_to_filename(reconstruction, "_mask")
            template_stack_estimator = \
                        tse.TemplateStackEstimator.from_mask(
                            reconstruction_mask,
                            args.dir_input_templates)
            template_mask = template_stack_estimator.get_path_to_template()
            template = template_mask.replace('_mask_dil.nii.gz', '.nii.gz')
            print('template name', template)
#            template = os.path.join(
#                        args.dir_input_templates,
#                        "STA%d.nii.gz" % args.gestational_age)
#            template_mask = os.path.join(
#                        args.dir_input_templates,
#                        "STA%d_mask.nii.gz" % args.gestational_age)
        else:
            template_folder = args.dir_output + "/../../mask_manual/reconstruct_outlier_gpr/"
            file_names = os.listdir(template_folder)
            template_names = [item for item in file_names if ("nii.gz" in item) and ("Masked" not in item)]
            mask_names = [item for item in file_names if ("nii.gz" in item) and ("Masked" in item)]
            template = os.path.join(template_folder, template_names[0])
            template_mask = os.path.join(template_folder, mask_names[0])

        cmd_args = []
        cmd_args.append("--moving %s" % reconstruction)
        cmd_args.append("--fixed %s" % template)
#        if(use_spatiotemporal_template is False):
#        cmd_args.append("--use-fixed-mask 1")  # added by Guotai
#        cmd_args.append("--template-mask %s" % template_mask) # micheal's code
        cmd_args.append("--dir-input %s" % os.path.join(
            dir_output_recon_subject_space,
            "motion_correction"))
        cmd_args.append("--dir-output %s" % dir_output_recon_template_space)
        cmd_args.append("--suffix-mask %s" % args.suffix_mask)
        cmd_args.append("--verbose %s" % args.verbose)
        cmd = "niftymic_register_image %s" % (" ").join(cmd_args)
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            raise RuntimeError("Registration to template space failed")

        # reconstruct volume in template space
        # pattern = "[a-zA-Z0-9_.]+(ResamplingToTemplateSpace.nii.gz)"
        # p = re.compile(pattern)
        # reconstruction_space = [
        #     os.path.join(dir_output_recon_template_space, p.match(f).group(0))
        #     for f in os.listdir(dir_output_recon_template_space)
        #     if p.match(f)][0]

        dir_input = os.path.join(
            dir_output_recon_template_space, "motion_correction")
        cmd_args = []
        cmd_args.append("--dir-input %s" % dir_input)
        cmd_args.append("--dir-output %s" % dir_output_recon_template_space)
        cmd_args.append("--reconstruction-space %s" % template)
        cmd_args.append("--iter-max %d" % args.iter_max)
        cmd_args.append("--alpha %s" % args.alpha)
        cmd_args.append("--suffix-mask %s" % args.suffix_mask)

        cmd = "niftymic_reconstruct_volume_from_slices %s" % \
            (" ").join(cmd_args)
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            raise RuntimeError("Reconstruction in template space failed")

        pattern = "[a-zA-Z0-9_.]+(stacks[0-9]+).*(.nii.gz)"
        p = re.compile(pattern)
        reconstruction = {
            p.match(f).group(1):
            os.path.join(
                dir_output_recon_template_space, p.match(f).group(0))
            for f in os.listdir(dir_output_recon_template_space)
            if p.match(f) and not p.match(f).group(0).endswith(
                "ResamplingToTemplateSpace.nii.gz")}
        key = reconstruction.keys()[0]
        path_to_recon = reconstruction[key]

        # Copy SRR to output directory
        output = "%sSRR_%s_GW%d.nii.gz" % (
            args.prefix_output, key, args.gestational_age)
        path_to_output = os.path.join(args.dir_output, output)
        cmd = "cp -p %s %s" % (path_to_recon, path_to_output)
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            raise RuntimeError("Copy of SRR to output directory failed")

        # Multiply template mask with reconstruction
        cmd_args = []
        cmd_args.append("--filename %s" % path_to_output)
        cmd_args.append("--gestational-age %s" % args.gestational_age)
        cmd_args.append("--verbose %s" % args.verbose)
        cmd_args.append("--dir-input-templates %s " % args.dir_input_templates)
        cmd = "niftymic_multiply_stack_with_mask %s" % (
            " ").join(cmd_args)
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            raise RuntimeError("SRR brain masking failed")

    else:
        elapsed_time_template = ph.get_zero_time()

    if args.run_data_vs_simulated_data:

        dir_input = os.path.join(
            dir_output_recon_template_space, "motion_correction")

        pattern = "[a-zA-Z0-9_.]+(stacks[0-9]+).*(.nii.gz)"
        # pattern = "Masked_[a-zA-Z0-9_.]+(stacks[0-9]+).*(.nii.gz)"
        p = re.compile(pattern)
        reconstruction = {
            p.match(f).group(1):
            os.path.join(
                dir_output_recon_template_space, p.match(f).group(0))
            for f in os.listdir(dir_output_recon_template_space)
            if p.match(f) and not p.match(f).group(0).endswith(
                "ResamplingToTemplateSpace.nii.gz")}
        key = reconstruction.keys()[0]
        path_to_recon = reconstruction[key]

        # Get simulated/projected slices
        cmd_args = []
        cmd_args.append("--dir-input %s" % dir_input)
        cmd_args.append("--dir-output %s" % dir_output_data_vs_simulatd_data)
        cmd_args.append("--reconstruction %s" % path_to_recon)
        cmd_args.append("--copy-data 1")
        cmd_args.append("--suffix-mask %s" % args.suffix_mask)
        # cmd_args.append("--verbose %s" % args.verbose)
        exe = os.path.abspath(simulate_stacks_from_reconstruction.__file__)
        cmd = "python %s %s" % (exe, (" ").join(cmd_args))
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            raise RuntimeError("SRR slice projections failed")

        filenames_simulated = [
            os.path.join(dir_output_data_vs_simulatd_data, os.path.basename(f))
            for f in input_files]

        dir_output_evaluation = os.path.join(
            dir_output_data_vs_simulatd_data, "evaluation")
        dir_output_figures = os.path.join(
            dir_output_data_vs_simulatd_data, "figures")
        dir_output_side_by_side = os.path.join(
            dir_output_figures, "side-by-side")

        # Evaluate slice similarities to ground truth
        cmd_args = []
        cmd_args.append("--filenames %s" % (" ").join(filenames_simulated))
        cmd_args.append("--suffix-mask %s" % args.suffix_mask)
        cmd_args.append("--measures NCC SSIM")
        cmd_args.append("--dir-output %s" % dir_output_evaluation)
        exe = os.path.abspath(evaluate_simulated_stack_similarity.__file__)
        cmd = "python %s %s" % (exe, (" ").join(cmd_args))
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            raise RuntimeError("Evaluation of slice similarities failed")

        # Generate figures showing the quantitative comparison
        cmd_args = []
        cmd_args.append("--dir-input %s" % dir_output_evaluation)
        cmd_args.append("--dir-output %s" % dir_output_figures)
        exe = os.path.abspath(
            show_evaluated_simulated_stack_similarity.__file__)
        cmd = "python %s %s" % (exe, (" ").join(cmd_args))
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            ph.print_warning("Visualization of slice similarities failed")

        # Generate pdfs showing all the side-by-side comparisons
        cmd_args = []
        cmd_args.append("--filenames %s" % (" ").join(filenames_simulated))
        cmd_args.append("--dir-output %s" % dir_output_side_by_side)
        exe = os.path.abspath(
            export_side_by_side_simulated_vs_original_slice_comparison.__file__)
        cmd = "python %s %s" % (exe, (" ").join(cmd_args))
        exit_code = ph.execute_command(cmd)
        if exit_code != 0:
            raise RuntimeError("Generation of PDF overview failed")

    ph.print_title("Summary")
    print("Computational Time for Volumetric Reconstruction: %s" %
          elapsed_time_volrec)
    print("Computational Time for Pipeline: %s" %
          ph.stop_timing(time_start))

    return 0