def build_compendia(concordances, identifiers):
""":concordances: a list of files from which to read relationships
:identifiers: a list of files from which to read identifiers and optional categories"""
dicts = {}
types = {}
for ifile in identifiers:
print(ifile)
new_identifiers, new_types = read_identifier_file(ifile)
glom(dicts, new_identifiers, unique_prefixes=[UBERON, GO])
types.update(new_types)
for infile in concordances:
print(infile)
print('loading', infile)
pairs = []
with open(infile, 'r') as inf:
for line in inf:
x = line.strip().split('\t')
pairs.append(set([x[0], x[2]]))
newpairs = remove_overused_xrefs(pairs)
glom(dicts, newpairs, unique_prefixes=[UBERON, GO])
typed_sets = create_typed_sets(set([frozenset(x) for x in dicts.values()]),
types)
for biotype, sets in typed_sets.items():
baretype = biotype.split(':')[-1]
write_compendium(sets, f'{baretype}.txt', biotype, {})
def build_protein_compendia(concordances, identifiers):
""":concordances: a list of files from which to read relationships
:identifiers: a list of files from which to read identifiers and optional categories"""
dicts = {}
types = {}
uniques = [UNIPROTKB, PR]
for ifile in identifiers:
print(ifile)
new_identifiers, new_types = read_identifier_file(ifile)
glom(dicts, new_identifiers, unique_prefixes=uniques)
types.update(new_types)
for infile in concordances:
print(infile)
print('loading', infile)
pairs = []
with open(infile, 'r') as inf:
for line in inf:
x = line.strip().split('\t')
pairs.append(set([x[0], x[2]]))
glom(dicts, pairs, unique_prefixes=uniques)
gene_sets = set([frozenset(x) for x in dicts.values()])
#Try to preserve some memory here.
dicts.clear()
baretype = PROTEIN.split(':')[-1]
write_compendium(gene_sets, f'{baretype}.txt', PROTEIN, {})
def build_compendia(identifiers):
""":concordances: a list of files from which to read relationships
:identifiers: a list of files from which to read identifiers and optional categories"""
dicts = {}
types = {}
uniques = []
for ifile in identifiers:
print('loading', ifile)
new_identifiers, new_types = read_identifier_file(ifile)
glom(dicts, new_identifiers, unique_prefixes=uniques)
types.update(new_types)
genefam_sets = set([frozenset(x) for x in dicts.values()])
baretype = GENE_FAMILY.split(':')[-1]
write_compendium(genefam_sets, f'{baretype}.txt', GENE_FAMILY, {})
def build_compendium(concordances, identifiers, mondoclose, badxrefs):
""":concordances: a list of files from which to read relationships
:identifiers: a list of files from which to read identifiers and optional categories"""
dicts = {}
types = {}
for ifile in identifiers:
print(ifile)
new_identifiers,new_types = read_identifier_file(ifile)
glom(dicts, new_identifiers, unique_prefixes=[MONDO, HP])
types.update(new_types)
#Load close Mondos
with open(mondoclose, 'r') as inf:
close_mondos = defaultdict(set)
for line in inf:
x = tuple(line.strip().split('\t'))
close_mondos[x[0]].add(x[1])
#Load and glom concords
for infile in concordances:
print(infile)
pairs = []
pref = path.basename(infile)
if pref in badxrefs:
print('reading bad xrefs',pref)
bad_pairs = read_badxrefs(badxrefs[pref])
else:
print('no bad pairs', pref)
bad_pairs = set()
with open(infile,'r') as inf:
for line in inf:
stuff = line.strip().split('\t')
x = tuple( [stuff[0], stuff[2]] )
if len(x) != 2:
print(x)
exit()
if x not in bad_pairs:
pairs.append( x )
if pref in ['MONDO','HP','EFO']:
newpairs = remove_overused_xrefs(pairs)
else:
newpairs = pairs
glom(dicts, newpairs, unique_prefixes=[MONDO, HP], close={MONDO:close_mondos})
try:
print(dicts['OMIM:607644'])
except:
print('notyet')
typed_sets = create_typed_sets(set([frozenset(x) for x in dicts.values()]),types)
for biotype,sets in typed_sets.items():
baretype = biotype.split(':')[-1]
write_compendium(sets,f'{baretype}.txt',biotype,{})
def build_gene_compendia(concordances, identifiers):
""":concordances: a list of files from which to read relationships
:identifiers: a list of files from which to read identifiers and optional categories"""
dicts = {}
types = {}
uniques = [NCBIGENE,HGNC,ENSEMBL,OMIM]
for ifile in identifiers:
print('loading',ifile)
new_identifiers, new_types = read_identifier_file(ifile)
glom(dicts, new_identifiers, unique_prefixes= uniques)
types.update(new_types)
for infile in concordances:
print(infile)
print('loading', infile)
pairs = []
with open(infile, 'r') as inf:
for line in inf:
x = line.strip().split('\t')
pairs.append(set([x[0], x[2]]))
glom(dicts, pairs, unique_prefixes=uniques)
gene_sets = set([frozenset(x) for x in dicts.values()])
baretype = GENE.split(':')[-1]
write_compendium(gene_sets, f'{baretype}.txt', GENE, {})
def build_compendia(concordances, identifiers,unichem_partial):
""":concordances: a list of files from which to read relationships
:identifiers: a list of files from which to read identifiers and optional categories"""
dicts = read_partial_unichem(unichem_partial)
types = {}
for ifile in identifiers:
print(ifile)
new_identifiers,new_types = read_identifier_file(ifile)
glom(dicts, new_identifiers, unique_prefixes=[INCHIKEY])
types.update(new_types)
for infile in concordances:
print(infile)
print('loading',infile)
pairs = []
with open(infile,'r') as inf:
for line in inf:
x = line.strip().split('\t')
pairs.append( set([x[0], x[2]]))
newpairs = remove_overused_xrefs(pairs)
glom(dicts, newpairs, unique_prefixes=[INCHIKEY])
chem_sets = set([frozenset(x) for x in dicts.values()])
baretype = CHEMICAL_SUBSTANCE.split(':')[-1]
write_compendium(chem_sets, f'{baretype}.txt', CHEMICAL_SUBSTANCE, {})
def build_compendia(concordances, identifiers):
""":concordances: a list of files from which to read relationships
:identifiers: a list of files from which to read identifiers and optional categories"""
#These are concords that cause problems and are being special cased out. In disease/process we put these in some
# files, and maybe we should here too?
#GO:0034227/EC:2.8.1.4 is because that go term is a biological process, but EC is not a valid prefix for that,
# leading to a loss of the EC term (and a unified RHEA) on output.
bad_concords = set(frozenset(['GO:0034227', 'EC:2.8.1.4']))
dicts = {}
types = {}
for ifile in identifiers:
print(ifile)
new_identifiers, new_types = read_identifier_file(ifile)
glom(dicts, new_identifiers, unique_prefixes=[GO])
types.update(new_types)
for infile in concordances:
print(infile)
print('loading', infile)
pairs = []
with open(infile, 'r') as inf:
for line in inf:
x = line.strip().split('\t')
pair = frozenset([x[0], x[2]])
if pair not in bad_concords:
pairs.append(pair)
#one kind of error is that GO->Reactome xrefs are freqently more like subclass relations. So
# GO:0004674 (protein serine/threonine kinase) has over 400 Reactome xrefs
# remove_overused_xrefs assumes that we want to remove pairs where the second pair is overused
# but this case it's the first, so we use the bothways optoin
newpairs = remove_overused_xrefs(pairs, bothways=True)
glom(dicts, newpairs, unique_prefixes=[GO])
typed_sets = create_typed_sets(set([frozenset(x) for x in dicts.values()]),
types)
for biotype, sets in typed_sets.items():
baretype = biotype.split(':')[-1]
write_compendium(sets, f'{baretype}.txt', biotype, {})
def load_diseases_and_phenotypes(concords,idlists,badhpos,badhpoxrefs):
#print('disease/phenotype')
#print('get and write hp sets')
#bad_mappings = read_bad_hp_mappings(badhpos)
#more_bad_mappings = read_badxrefs(badhpoxrefs)
#for h,m in more_bad_mappings.items():
# bad_mappings[h].update(m)
#hpo_sets,labels = build_sets('HP:0000118', ignore_list = ['ICD','NCIT'], bad_mappings = bad_mappings)
#print('filter')
hpo_sets = filter_out_non_unique_ids(hpo_sets)
#print('ok')
#dump_sets(hpo_sets,'hpo_sets.txt')
print('get and write mondo sets')
#MONDO has disease, and its sister disease susceptibility. I'm putting both in disease. Biolink q
#But! this is a problem right now because there are some things that go in both, and they are getting filtered out
bad_mondo_mappings = read_badxrefs('mondo')
mondo_sets_1,labels_1 = build_exact_sets('MONDO:0000001',bad_mondo_mappings)
mondo_sets_2,labels_2 = build_exact_sets('MONDO:0042489',bad_mondo_mappings)
mondo_close = get_close_matches('MONDO:0000001')
mondo_close2 = get_close_matches('MONDO:0042489')
for k,v in mondo_close2.items():
mondo_close[k] = v
dump_sets(mondo_sets_1,'mondo1.txt')
dump_sets(mondo_sets_2,'mondo2.txt')
labels.update(labels_1)
labels.update(labels_2)
#if we just add these together, then any mondo in both lists will get filtered out in the next step.
#so we need to put them into a set. You can't put sets directly into a set, you have to freeze them first
mondo_sets = combine_id_sets(mondo_sets_1,mondo_sets_2)
mondo_sets = filter_out_non_unique_ids(mondo_sets)
dump_sets(mondo_sets,'mondo_sets.txt')
print('get and write umls sets')
bad_umls = read_badxrefs('umls')
meddra_umls,secondary_meddra_umls = read_meddra(bad_umls)
meddra_umls = filter_umls(meddra_umls,mondo_sets+hpo_sets,'filtered.txt')
secondary_meddra_umls = filter_umls(secondary_meddra_umls,mondo_sets+hpo_sets,'filtered_secondary.txt')
#Now, if we just use all the secondary links, things get too agglommed.
# So instead, lets filter these again.
meddra_umls += filter_secondaries(secondary_meddra_umls,'double_filter.txt')
dump_sets(meddra_umls,'meddra_umls_sets.txt')
dicts = {}
#EFO has 3 parts that we want here:
# Disease
efo_sets_1,l = build_exact_sets('EFO:0000408')
labels.update(l)
#phenotype
efo_sets_2,l = build_exact_sets('EFO:0000651')
labels.update(l)
#measurement
efo_sets_3,l = build_exact_sets('EFO:0001444')
labels.update(l)
efo_sets_a = combine_id_sets(efo_sets_1,efo_sets_2)
efo_sets = combine_id_sets(efo_sets_a, efo_sets_3)
efo_sets = filter_out_non_unique_ids(efo_sets)
dump_sets(efo_sets,'efo_sets.txt')
print('put it all together')
print('mondo')
glom(dicts,mondo_sets,unique_prefixes=['MONDO'])
dump_dicts(dicts,'mondo_dicts.txt')
print('hpo')
glom(dicts,hpo_sets,unique_prefixes=['MONDO'],pref='HP')
dump_dicts(dicts,'mondo_hpo_dicts.txt')
print('umls')
glom(dicts,meddra_umls,unique_prefixes=['MONDO','HP'],pref='UMLS',close={'MONDO':mondo_close})
dump_dicts(dicts,'mondo_hpo_meddra_dicts.txt')
print('efo')
glom(dicts,efo_sets,unique_prefixes=['MONDO','HP'],pref='EFO')
dump_dicts(dicts,'mondo_hpo_meddra_efo_dicts.txt')
print('dump it')
fs = set([frozenset(x) for x in dicts.values()])
diseases,phenotypes = create_typed_sets(fs)
write_compendium(diseases,'disease.txt','biolink:Disease',labels)
write_compendium(phenotypes,'phenotypes.txt','biolink:PhenotypicFeature',labels)