def variation_effects(vrn_file, genome_file, genome_build, config): """Calculate effects of variations, associating them with transcripts. """ snpeff_vcf, snpeff_txt = snpeff_effects(vrn_file, genome_build, config) annotated_vcf = annotate_effects(vrn_file, snpeff_vcf, genome_file, config) \ if snpeff_vcf else None return annotated_vcf, snpeff_txt