Example #1
0
from moose_nerp.prototypes.util import NamedList, NamedDict
from moose_nerp.prototypes.syn_proto import SynChannelParams, MgParams

from . import param_cond

#Parameters for synpases (SI units):
#Erev (Volts), tau1 & tau2 (sec)
#Gbar units: Siemens/meter squared
#C is concentration of Mg in mM, A is 1/eta and B is 1/gamma,

#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
_NMDA_MgParams = MgParams(A=1 / 6.0, B=1 / 80.0, C=1.4)

#Lavian Eur J Neurosci: Egaba=-75 mV, amp ~1mV at -60 mV
_SynGaba = SynChannelParams(Erev=-75e-3,
                            tau1=0.5e-3,
                            tau2=10e-3,
                            Gbar=0.25e-9,
                            var=0.05)
#may need two time constants of decay to match Lavian
#Use 1.5e-9 for str and 3e-9 for GPe?
_SynAMPA = SynChannelParams(Erev=0,
                            tau1=1e-3,
                            tau2=3e-3,
                            Gbar=0.15e-9,
                            var=0.05,
                            spinic=True)
Example #2
0
from moose_nerp.prototypes.syn_proto import SynChannelParams, MgParams, DesensitizationParams

from . import param_cond

#Parameters for inhibitory synpases:
#Erev, tau1, tau2  (SI units)

#C is concentration of Mg, A is 1/eta and B is 1/gamma,
#Rebekah's:
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
desenYN = 0
_NMDA_MgParams = MgParams(A=1 / 18.0, B=1 / 99.0, C=1.4)

#Sriram uses 0.109e-9 for AMPA and 0.9e-9 for Gaba
_SynGaba = SynChannelParams(Erev=-60e-3,
                            tau1=0.25e-3,
                            tau2=3.75e-3,
                            Gbar=0.2e-9,
                            nmdaCaFrac=0.0,
                            var=0.05)

SynGabaNPY = SynChannelParams(
    Erev=-60e-3,  #NPY
    tau1=0.25e-3,
    tau2=80.75e-3,
    Gbar=0.5e-9,
    nmdaCaFrac=0.0,
Example #3
0
from . import param_cond

#Parameters for inhibitory synpases:
#Erev, tau1, tau2  (SI units)

#C is concentration of Mg, A is 1/eta and B is 1/gamma,
#Rebekah's:
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
desenYN = 0
_NMDA_MgParams = MgParams(
    A=1 / 18.0,  #3.57,#18.0,
    B=1 / 99.0,  #62.0,#99.0,
    C=1.0)

#Sriram uses 0.109e-9 for AMPA and 0.9e-9 for Gaba
_SynGaba = SynChannelParams(Erev=-60e-3,
                            tau1=0.25e-3,
                            tau2=3.75e-3,
                            Gbar=0.2e-9,
                            nmdaCaFrac=0.0,
                            var=0.05)

SynGabaNPY = SynChannelParams(
    Erev=-60e-3,  #NPY
    tau1=0.25e-3,
    tau2=80.75e-3,
    Gbar=0.5e-9,