def library1():
import moose.genesis
import moose.SBML
import moose.chemMerge
import moose.utils
import moose.network_utils
print('done')
p1 = moose.le()
a = moose.Pool('/a')
for i in range(10):
moose.Pool('/a/p%d' % i)
p2 = moose.le()
assert set(p2) - set(p1) == set(['/a'])
aa = moose.le(a)
assert len(aa) == 10
try:
moose.syncDataHandler('/a')
except NotImplementedError:
pass
try:
moose.showfield('/x')
except ValueError:
pass
moose.showfield('/a')
moose.showfields('/a')
def main():
runtime = 2000
displayInterval = 2
makeModel()
dsolve = moose.element('/model/dsolve')
moose.reinit()
#moose.start( runtime ) # Run the model for 10 seconds.
a = moose.element('/model/compartment/a')
b = moose.element('/model/compartment/b')
s = moose.element('/model/compartment/s')
print moose.showfields(a)
# img = mpimg.imread( 'turingPatternTut.png' )
#imgplot = plt.imshow( img )
#plt.show()
plt.ion()
fig = plt.figure(figsize=(12, 10))
png = fig.add_subplot(211)
# imgplot = plt.imshow( img )
ax = fig.add_subplot(212)
ax.set_ylim(0, 2)
plt.ylabel('Conc (mM)')
plt.xlabel('Position along cylinder (microns)')
pos = numpy.arange(0, a.vec.conc.size, 1)
line1, = ax.plot(pos, a.vec.conc, label='a')
line2, = ax.plot(pos, b.vec.conc, label='b')
timeLabel = plt.text(60, 0.4, 'time = 0')
plt.legend()
fig.canvas.draw()
for t in range(displayInterval, runtime, displayInterval):
#if t>150 and t<170:
#a.vec[80].conc = 1.2
#b.vec[85].conc *= 1.2
#s.vec[85].conc *= 1.2
#a.vec[80].concInit *= 1.2
#print 'entering the condition'
moose.start(displayInterval)
line1.set_ydata(a.vec.conc)
line2.set_ydata(b.vec.conc)
timeLabel.set_text("time = %d" % t)
fig.canvas.draw()
print(a.vec.conc)
file = open('c41', 'w')
ty = 0
for tin in a.vec.conc:
tout = str(tin)
ty = ty + 1
file.write(str(ty) + ' ' + tout + '\n')
print("Hit 'enter' to exit")
raw_input()
def makeModel():
model = moose.Neutral( '/model' )
# Make neuronal model. It has no channels, just for geometry
cell = moose.loadModel( './branching.p', '/model/cell', 'Neutral' )
# We don't want the cell to do any calculations. Disable everything.
for i in moose.wildcardFind( '/model/cell/##' ):
i.tick = -1
# create container for model
model = moose.element( '/model' )
chem = moose.Neutral( '/model/chem' )
# The naming of the compartments is dicated by the places that the
# chem model expects to be loaded.
compt0 = moose.NeuroMesh( '/model/chem/compt0' )
compt0.separateSpines = 0
compt0.geometryPolicy = 'cylinder'
#reacSystem = moose.loadModel( 'simpleOsc.g', '/model/chem', 'ee' )
makeChemModel( compt0 ) # Populate all compt with the chem system.
compt0.diffLength = 1e-6 # This will be over 100 compartments.
# This is the magic command that configures the diffusion compartments.
compt0.cell = cell
moose.showfields( compt0 )
# Build the solvers. No need for diffusion in this version.
ksolve0 = moose.Ksolve( '/model/chem/compt0/ksolve' )
dsolve0 = moose.Dsolve( '/model/chem/compt0/dsolve' )
stoich0 = moose.Stoich( '/model/chem/compt0/stoich' )
# Configure solvers
stoich0.compartment = compt0
stoich0.ksolve = ksolve0
stoich0.dsolve = dsolve0
stoich0.path = '/model/chem/compt0/#'
assert( stoich0.numVarPools == 3 )
assert( stoich0.numProxyPools == 0 )
assert( stoich0.numRates == 4 )
num = compt0.numDiffCompts - 1
moose.element( '/model/chem/compt0/a[' + str(num) + ']' ).concInit *= 1.5
# Create the output tables
graphs = moose.Neutral( '/model/graphs' )
makeTab( 'a_soma', '/model/chem/compt0/a[0]' )
makeTab( 'b_soma', '/model/chem/compt0/b[0]' )
makeTab( 'a_apical', '/model/chem/compt0/a[' + str( num ) + ']' )
makeTab( 'b_apical', '/model/chem/compt0/b[' + str( num ) + ']' )
def makeModel():
model = moose.Neutral("/model")
# Make neuronal model. It has no channels, just for geometry
cell = moose.loadModel("./branching.p", "/model/cell", "Neutral")
# We don't want the cell to do any calculations. Disable everything.
for i in moose.wildcardFind("/model/cell/##"):
i.tick = -1
# create container for model
model = moose.element("/model")
chem = moose.Neutral("/model/chem")
# The naming of the compartments is dicated by the places that the
# chem model expects to be loaded.
compt0 = moose.NeuroMesh("/model/chem/compt0")
compt0.separateSpines = 0
compt0.geometryPolicy = "cylinder"
# reacSystem = moose.loadModel( 'simpleOsc.g', '/model/chem', 'ee' )
makeChemModel(compt0) # Populate all compt with the chem system.
compt0.diffLength = 1e-6 # This will be over 100 compartments.
# This is the magic command that configures the diffusion compartments.
compt0.subTreePath = cell.path + "/#"
moose.showfields(compt0)
# Build the solvers. No need for diffusion in this version.
ksolve0 = moose.Ksolve("/model/chem/compt0/ksolve")
dsolve0 = moose.Dsolve("/model/chem/compt0/dsolve")
stoich0 = moose.Stoich("/model/chem/compt0/stoich")
# Configure solvers
stoich0.compartment = compt0
stoich0.ksolve = ksolve0
stoich0.dsolve = dsolve0
stoich0.path = "/model/chem/compt0/#"
assert stoich0.numVarPools == 3
assert stoich0.numProxyPools == 0
assert stoich0.numRates == 4
num = compt0.numDiffCompts - 1
moose.element("/model/chem/compt0/a[" + str(num) + "]").concInit *= 1.5
# Create the output tables
graphs = moose.Neutral("/model/graphs")
makeTab("a_soma", "/model/chem/compt0/a[0]")
makeTab("b_soma", "/model/chem/compt0/b[0]")
makeTab("a_apical", "/model/chem/compt0/a[" + str(num) + "]")
makeTab("b_apical", "/model/chem/compt0/b[" + str(num) + "]")
def main():
neuron = moose.Neutral("/neuron")
inputs = moose.Neutral("/inputs")
outputs = moose.Neutral("/outputs")
soma = create_spherical_compartment("/neuron/soma", 25e-6, 20e-6, 2.8, 4.0,
0.03)
pulse = create_pulse('/inputs/somaPulse', 50e-3, 100e-3, 1e-9, soma)
vmtable = create_table('outputs/somaVmTable', soma, "getVm")
print(soma.tick)
print(soma.dt)
moose.reinit()
moose.start(300e-3)
moose.showfields(vmtable)
moose.showmsg(soma)
moose.showmsg(pulse)
moose.showmsg(vmtable)
plot_table(vmtable)
pyplot.show()
def test_simple():
"""First test.
>>> test_simple() # doctest: +NORMALIZE_WHITESPACE
Rdesigneur: Elec model has 1 compartments and 0 spines on 0 compartments.
<BLANKLINE>
[/model[0]/elec[0]/soma[0]]
Cm =7.853981633975e-09
Em =-0.0544
Im =1.3194689277024895e-08
Ra =7639437.268410473
Rm =424413.1773342278
Vm =-0.06
className =ZombieCompartment
diameter =0.0005
dt =0.0
fieldIndex =0
idValue =455
index =0
initVm =-0.065
inject =0.0
length =0.0005
name =soma
numData =1
numField =1
path =/model[0]/elec[0]/soma[0]
tick =-2
x =0.0005
x0 =0.0
y =0.0
y0 =0.0
z =0.0
z0 =0.0
<BLANKLINE>
INCOMING:
/model[0]/elec[0]/soma ('parentMsg',) <--- /model[0]/elec ('childOut',)
OUTGOING:
"""
rdes = rd.rdesigneur()
rdes.buildModel()
moose.showfields(rdes.soma)
moose.showmsg(rdes.soma)
def makeModel():
"""
This example illustrates how to set up a oscillatory Turing pattern
in 1-D using reaction diffusion calculations.
Reaction system is::
s ---a---> a // s goes to a, catalyzed by a.
s ---a---> b // s goes to b, catalyzed by a.
a ---b---> s // a goes to s, catalyzed by b.
b -------> s // b is degraded irreversibly to s.
s ----Receptor---> a // Receptor is activated by the ligand to cause an increase the conc of a. Here ligand-receptor interaction is not accounted for.
in sum, **a** has a positive feedback onto itself and also forms **b**.
**b** has a negative feedback onto **a**.
Finally, the diffusion constant for **a** is 1/10 that of **b**.
This chemical system is present in a 1-dimensional (cylindrical)
compartment. The entire reaction-diffusion system is set up
within the script.
"""
# create container for model
r0 = 1e-6 # m
r1 = 1e-6 # m
num = 100
diffLength = 1e-7 # m
len = num * diffLength # m
diffConst = 1e-13 # m^2/sec
motorRate = 1e-6 # m/sec
concA = 1 # millimolar
dt4 = 0.5 # for the diffusion
dt5 = 0.2 # for the reaction
model = moose.Neutral('model')
compartment = moose.CylMesh('/model/compartment')
compartment.r0 = r0
compartment.r1 = r1
compartment.x0 = 0
compartment.x1 = len
compartment.diffLength = diffLength
assert (compartment.numDiffCompts == num)
# create molecules and reactions
a = moose.Pool('/model/compartment/a')
b = moose.Pool('/model/compartment/b')
s = moose.Pool('/model/compartment/s')
e1 = moose.MMenz('/model/compartment/e1')
e2 = moose.MMenz('/model/compartment/e2')
e3 = moose.MMenz('/model/compartment/e3')
e4 = moose.MMenz('/model/compartment/e4')
r1 = moose.Reac('/model/compartment/r1')
rec = moose.Pool('/model/compartment/rec')
moose.connect(e1, 'sub', s, 'reac')
moose.connect(e1, 'prd', a, 'reac')
moose.connect(a, 'nOut', e1, 'enzDest')
e1.Km = 1
e1.kcat = 1
moose.connect(e2, 'sub', s, 'reac')
moose.connect(e2, 'prd', b, 'reac')
moose.connect(a, 'nOut', e2, 'enzDest')
e2.Km = 1
e2.kcat = 0.5
moose.connect(e3, 'sub', a, 'reac')
moose.connect(e3, 'prd', s, 'reac')
moose.connect(b, 'nOut', e3, 'enzDest')
e3.Km = 0.1
e3.kcat = 1
moose.connect(r1, 'sub', b, 'reac')
moose.connect(r1, 'prd', s, 'reac')
r1.Kf = 0.3 # 1/sec
r1.Kb = 0. # 1/sec
moose.connect(e4, 'sub', s, 'reac')
moose.connect(e4, 'prd', a, 'reac')
moose.connect(rec, 'nOut', e4, 'enzDest')
e4.Km = 0.001
e4.kcat = 4
# Assign parameters
a.diffConst = diffConst / 10
b.diffConst = diffConst
s.diffConst = diffConst
rec.diffConst = diffConst / 20
# Make solvers
ksolve = moose.Ksolve('/model/compartment/ksolve')
dsolve = moose.Dsolve('/model/dsolve')
# Set up clocks. The dsolver to know before assigning stoich
moose.setClock(4, dt4)
moose.setClock(5, dt5)
moose.useClock(4, '/model/dsolve', 'process')
# Ksolve must be scheduled after dsolve.
moose.useClock(5, '/model/compartment/ksolve', 'process')
stoich = moose.Stoich('/model/compartment/stoich')
stoich.compartment = compartment
stoich.ksolve = ksolve
stoich.dsolve = dsolve
stoich.path = "/model/compartment/##"
assert (dsolve.numPools == 4)
a.vec.concInit = [0.1] * num
# a.vec[50].concInit *= 1.2 # slight perturbation at one end.
a.vec[10].concInit *= 1.2
a.vec[35].concInit *= 1.2
a.vec[60].concInit *= 1.2
a.vec[85].concInit *= 1.2
print moose.showfields(a)
b.vec.concInit = [0.1] * num
s.vec.concInit = [1] * num
rec.vec.concInit = [0] * num
def makeModel():
model = moose.Neutral( '/model' )
# Make neuronal model. It has no channels, just for geometry
cell = moose.loadModel( './spinyNeuron.p', '/model/cell', 'Neutral' )
# We don't want the cell to do any calculations. Disable everything.
for i in moose.wildcardFind( '/model/cell/##' ):
i.tick = -1
# create container for model
model = moose.element( '/model' )
chem = moose.Neutral( '/model/chem' )
# The naming of the compartments is dicated by the places that the
# chem model expects to be loaded.
compt0 = moose.NeuroMesh( '/model/chem/compt0' )
compt0.separateSpines = 1
compt0.geometryPolicy = 'cylinder'
compt1 = moose.SpineMesh( '/model/chem/compt1' )
moose.connect( compt0, 'spineListOut', compt1, 'spineList', 'OneToOne' )
compt2 = moose.PsdMesh( '/model/chem/compt2' )
moose.connect( compt0, 'psdListOut', compt2, 'psdList', 'OneToOne' )
#reacSystem = moose.loadModel( 'simpleOsc.g', '/model/chem', 'ee' )
makeChemModel( compt0, True ) # Populate all 3 compts with the chem system.
makeChemModel( compt1, False )
makeChemModel( compt2, True )
compt0.diffLength = 2e-6 # This will be over 100 compartments.
# This is the magic command that configures the diffusion compartments.
compt0.subTreePath = cell.path + "/#"
moose.showfields( compt0 )
# Build the solvers. No need for diffusion in this version.
ksolve0 = moose.Ksolve( '/model/chem/compt0/ksolve' )
if useGssa:
ksolve1 = moose.Gsolve( '/model/chem/compt1/ksolve' )
ksolve2 = moose.Gsolve( '/model/chem/compt2/ksolve' )
else:
ksolve1 = moose.Ksolve( '/model/chem/compt1/ksolve' )
ksolve2 = moose.Ksolve( '/model/chem/compt2/ksolve' )
dsolve0 = moose.Dsolve( '/model/chem/compt0/dsolve' )
dsolve1 = moose.Dsolve( '/model/chem/compt1/dsolve' )
dsolve2 = moose.Dsolve( '/model/chem/compt2/dsolve' )
stoich0 = moose.Stoich( '/model/chem/compt0/stoich' )
stoich1 = moose.Stoich( '/model/chem/compt1/stoich' )
stoich2 = moose.Stoich( '/model/chem/compt2/stoich' )
# Configure solvers
stoich0.compartment = compt0
stoich1.compartment = compt1
stoich2.compartment = compt2
stoich0.ksolve = ksolve0
stoich1.ksolve = ksolve1
stoich2.ksolve = ksolve2
stoich0.dsolve = dsolve0
stoich1.dsolve = dsolve1
stoich2.dsolve = dsolve2
stoich0.path = '/model/chem/compt0/#'
stoich1.path = '/model/chem/compt1/#'
stoich2.path = '/model/chem/compt2/#'
assert( stoich0.numVarPools == 1 )
assert( stoich0.numProxyPools == 0 )
assert( stoich0.numRates == 1 )
assert( stoich1.numVarPools == 1 )
assert( stoich1.numProxyPools == 0 )
if useGssa:
assert( stoich1.numRates == 2 )
assert( stoich2.numRates == 2 )
else:
assert( stoich1.numRates == 1 )
assert( stoich2.numRates == 1 )
assert( stoich2.numVarPools == 1 )
assert( stoich2.numProxyPools == 0 )
dsolve0.buildNeuroMeshJunctions( dsolve1, dsolve2 )
stoich0.buildXreacs( stoich1 )
stoich1.buildXreacs( stoich2 )
stoich0.filterXreacs()
stoich1.filterXreacs()
stoich2.filterXreacs()
Ca_input_dend = moose.vec( '/model/chem/compt0/Ca_input' )
print(len( Ca_input_dend ))
for i in range( 60 ):
Ca_input_dend[ 3 + i * 3 ].conc = 2.0
Ca_input_PSD = moose.vec( '/model/chem/compt2/Ca_input' )
print((len( Ca_input_PSD )))
for i in range( 5 ):
Ca_input_PSD[ 2 + i * 2].conc = 1.0
# Create the output tables
num = compt0.numDiffCompts - 1
graphs = moose.Neutral( '/model/graphs' )
makeTab( 'Ca_soma', '/model/chem/compt0/Ca[0]' )
makeTab( 'Ca_d1', '/model/chem/compt0/Ca[1]' )
makeTab( 'Ca_d2', '/model/chem/compt0/Ca[2]' )
makeTab( 'Ca_d3', '/model/chem/compt0/Ca[3]' )
makeTab( 'Ca_s3', '/model/chem/compt1/Ca[3]' )
makeTab( 'Ca_s4', '/model/chem/compt1/Ca[4]' )
makeTab( 'Ca_s5', '/model/chem/compt1/Ca[5]' )
makeTab( 'Ca_p3', '/model/chem/compt2/Ca[3]' )
makeTab( 'Ca_p4', '/model/chem/compt2/Ca[4]' )
makeTab( 'Ca_p5', '/model/chem/compt2/Ca[5]' )
def makeModel():
model = moose.Neutral('/model')
# Make neuronal model. It has no channels, just for geometry
cell = moose.loadModel('./spinyNeuron.p', '/model/cell', 'Neutral')
# We don't want the cell to do any calculations. Disable everything.
for i in moose.wildcardFind('/model/cell/##'):
i.tick = -1
# create container for model
model = moose.element('/model')
chem = moose.Neutral('/model/chem')
# The naming of the compartments is dicated by the places that the
# chem model expects to be loaded.
compt0 = moose.NeuroMesh('/model/chem/compt0')
compt0.separateSpines = 1
compt0.geometryPolicy = 'cylinder'
compt1 = moose.SpineMesh('/model/chem/compt1')
moose.connect(compt0, 'spineListOut', compt1, 'spineList', 'OneToOne')
compt2 = moose.PsdMesh('/model/chem/compt2')
moose.connect(compt0, 'psdListOut', compt2, 'psdList', 'OneToOne')
#reacSystem = moose.loadModel( 'simpleOsc.g', '/model/chem', 'ee' )
makeChemModel(compt0) # Populate all 3 compts with the chem system.
makeChemModel(compt1)
makeChemModel(compt2)
compt0.diffLength = 2e-6 # This will be over 100 compartments.
# This is the magic command that configures the diffusion compartments.
compt0.subTreePath = cell.path + "/##"
moose.showfields(compt0)
# Build the solvers. No need for diffusion in this version.
ksolve0 = moose.Ksolve('/model/chem/compt0/ksolve')
ksolve1 = moose.Gsolve('/model/chem/compt1/ksolve')
ksolve2 = moose.Gsolve('/model/chem/compt2/ksolve')
#dsolve0 = moose.Dsolve( '/model/chem/compt0/dsolve' )
#dsolve1 = moose.Dsolve( '/model/chem/compt1/dsolve' )
#dsolve2 = moose.Dsolve( '/model/chem/compt2/dsolve' )
stoich0 = moose.Stoich('/model/chem/compt0/stoich')
stoich1 = moose.Stoich('/model/chem/compt1/stoich')
stoich2 = moose.Stoich('/model/chem/compt2/stoich')
# Configure solvers
stoich0.compartment = compt0
stoich1.compartment = compt1
stoich2.compartment = compt2
stoich0.ksolve = ksolve0
stoich1.ksolve = ksolve1
stoich2.ksolve = ksolve2
#stoich0.dsolve = dsolve0
#stoich1.dsolve = dsolve1
#stoich2.dsolve = dsolve2
stoich0.path = '/model/chem/compt0/#'
stoich1.path = '/model/chem/compt1/#'
stoich2.path = '/model/chem/compt2/#'
assert (stoich0.numVarPools == 3)
assert (stoich0.numProxyPools == 0)
assert (stoich0.numRates == 4)
assert (stoich1.numVarPools == 3)
assert (stoich1.numProxyPools == 0)
#assert( stoich1.numRates == 4 )
assert (stoich2.numVarPools == 3)
assert (stoich2.numProxyPools == 0)
#assert( stoich2.numRates == 4 )
#dsolve0.buildNeuroMeshJunctions( dsolve1, dsolve2 )
stoich0.buildXreacs(stoich1)
stoich1.buildXreacs(stoich2)
stoich0.filterXreacs()
stoich1.filterXreacs()
stoich2.filterXreacs()
moose.element('/model/chem/compt2/a[0]').concInit *= 1.5
# Create the output tables
num = compt0.numDiffCompts - 1
graphs = moose.Neutral('/model/graphs')
makeTab('a_soma', '/model/chem/compt0/a[0]')
makeTab('b_soma', '/model/chem/compt0/b[0]')
makeTab('a_apical', '/model/chem/compt0/a[' + str(num) + ']')
makeTab('b_apical', '/model/chem/compt0/b[' + str(num) + ']')
makeTab('a_spine', '/model/chem/compt1/a[5]')
makeTab('b_spine', '/model/chem/compt1/b[5]')
makeTab('a_psd', '/model/chem/compt2/a[5]')
makeTab('b_psd', '/model/chem/compt2/b[5]')
def test1( ):
rdes = rd.rdesigneur()
rdes.buildModel()
moose.showfields( rdes.soma )
def test_mgblock():
model = moose.Neutral('/model')
data = moose.Neutral('/data')
soma = moose.Compartment('/model/soma')
soma.Em = -60e-3
soma.Rm = 1e7
soma.Cm = 1e-9
###################################################
# This is where we create the synapse with MgBlock
#--------------------------------------------------
nmda = moose.SynChan('/model/soma/nmda')
nmda.Gbar = 1e-9
mgblock = moose.MgBlock('/model/soma/mgblock')
mgblock.CMg = 2.0
mgblock.KMg_A = 1/0.33
mgblock.KMg_B = 1/60.0
# The synHandler manages the synapses and their learning rules if any.
synHandler = moose.SimpleSynHandler( '/model/soma/nmda/handler' )
synHandler.synapse.num = 1
moose.connect( synHandler, 'activationOut', nmda, 'activation' )
# MgBlock sits between original channel nmda and the
# compartment. The origChannel receives the channel message from
# the nmda SynChan.
moose.connect(soma, 'VmOut', nmda, 'Vm' )
moose.connect(nmda, 'channelOut', mgblock, 'origChannel')
moose.connect(mgblock, 'channel', soma, 'channel')
# This is for comparing with MgBlock
nmda_noMg = moose.copy(nmda, soma, 'nmda_noMg')
moose.connect( nmda_noMg, 'channel', soma, 'channel')
moose.le( nmda_noMg )
#########################################
# The rest is for experiment setup
spikegen = moose.SpikeGen('/model/spike')
pulse = moose.PulseGen('/model/input')
pulse.delay[0] = 10e-3
pulse.level[0] = 1.0
pulse.width[0] = 50e-3
moose.connect(pulse, 'output', spikegen, 'Vm')
moose.le( synHandler )
#syn = moose.element(synHandler.path + '/synapse' )
syn = synHandler.synapse[0]
syn.delay = simdt * 2
syn.weight = 10
moose.connect(spikegen, 'spikeOut', synHandler.synapse[0], 'addSpike')
moose.le( nmda_noMg )
noMgSyn = moose.element(nmda_noMg.path + '/handler/synapse' )
noMgSyn.delay = 0.01
noMgSyn.weight = 1
moose.connect(spikegen, 'spikeOut', noMgSyn, 'addSpike')
moose.showfields( syn )
moose.showfields( noMgSyn )
Gnmda = moose.Table('/data/Gnmda')
moose.connect(Gnmda, 'requestOut', mgblock, 'getGk')
Gnmda_noMg = moose.Table('/data/Gnmda_noMg')
moose.connect(Gnmda_noMg, 'requestOut', nmda_noMg, 'getGk')
Vm = moose.Table('/data/Vm')
moose.connect(Vm, 'requestOut', soma, 'getVm')
for i in range( 10 ):
moose.setClock( i, simdt )
moose.setClock( Gnmda.tick, plotdt )
print((spikegen.dt, Gnmda.dt))
moose.reinit()
moose.start( simtime )
t = pylab.linspace(0, simtime*1e3, len(Vm.vector))
pylab.plot(t, (Vm.vector + 0.06) * 1000, label='Vm (mV)')
pylab.plot(t, Gnmda.vector * 1e9, label='Gnmda (nS)')
pylab.plot(t, Gnmda_noMg.vector * 1e9, label='Gnmda no Mg (nS)')
pylab.legend()
#data = pylab.vstack((t, Gnmda.vector, Gnmda_noMg.vector)).transpose()
#pylab.savetxt('mgblock.dat', data)
pylab.show()
def makeModel():
model = moose.Neutral( '/model' )
# Make neuronal model. It has no channels, just for geometry
cell = moose.loadModel( './spinyNeuron.p', '/model/cell', 'Neutral' )
# We don't want the cell to do any calculations. Disable everything.
for i in moose.wildcardFind( '/model/cell/##' ):
i.tick = -1
# create container for model
model = moose.element( '/model' )
chem = moose.Neutral( '/model/chem' )
# The naming of the compartments is dicated by the places that the
# chem model expects to be loaded.
compt0 = moose.NeuroMesh( '/model/chem/compt0' )
compt0.separateSpines = 1
compt0.geometryPolicy = 'cylinder'
compt1 = moose.SpineMesh( '/model/chem/compt1' )
moose.connect( compt0, 'spineListOut', compt1, 'spineList', 'OneToOne' )
compt2 = moose.PsdMesh( '/model/chem/compt2' )
moose.connect( compt0, 'psdListOut', compt2, 'psdList', 'OneToOne' )
#reacSystem = moose.loadModel( 'simpleOsc.g', '/model/chem', 'ee' )
makeChemModel( compt0 ) # Populate all 3 compts with the chem system.
makeChemModel( compt1 )
makeChemModel( compt2 )
compt0.diffLength = 2e-6 # This will be over 100 compartments.
# This is the magic command that configures the diffusion compartments.
compt0.subTreePath = cell.path + "/##"
moose.showfields( compt0 )
# Build the solvers. No need for diffusion in this version.
ksolve0 = moose.Ksolve( '/model/chem/compt0/ksolve' )
ksolve1 = moose.Gsolve( '/model/chem/compt1/ksolve' )
ksolve2 = moose.Gsolve( '/model/chem/compt2/ksolve' )
#dsolve0 = moose.Dsolve( '/model/chem/compt0/dsolve' )
#dsolve1 = moose.Dsolve( '/model/chem/compt1/dsolve' )
#dsolve2 = moose.Dsolve( '/model/chem/compt2/dsolve' )
stoich0 = moose.Stoich( '/model/chem/compt0/stoich' )
stoich1 = moose.Stoich( '/model/chem/compt1/stoich' )
stoich2 = moose.Stoich( '/model/chem/compt2/stoich' )
# Configure solvers
stoich0.compartment = compt0
stoich1.compartment = compt1
stoich2.compartment = compt2
stoich0.ksolve = ksolve0
stoich1.ksolve = ksolve1
stoich2.ksolve = ksolve2
#stoich0.dsolve = dsolve0
#stoich1.dsolve = dsolve1
#stoich2.dsolve = dsolve2
stoich0.path = '/model/chem/compt0/#'
stoich1.path = '/model/chem/compt1/#'
stoich2.path = '/model/chem/compt2/#'
assert( stoich0.numVarPools == 3 )
assert( stoich0.numProxyPools == 0 )
assert( stoich0.numRates == 4 )
assert( stoich1.numVarPools == 3 )
assert( stoich1.numProxyPools == 0 )
#assert( stoich1.numRates == 4 )
assert( stoich2.numVarPools == 3 )
assert( stoich2.numProxyPools == 0 )
#assert( stoich2.numRates == 4 )
#dsolve0.buildNeuroMeshJunctions( dsolve1, dsolve2 )
stoich0.buildXreacs( stoich1 )
stoich1.buildXreacs( stoich2 )
stoich0.filterXreacs()
stoich1.filterXreacs()
stoich2.filterXreacs()
moose.element( '/model/chem/compt2/a[0]' ).concInit *= 1.5
# Create the output tables
num = compt0.numDiffCompts - 1
graphs = moose.Neutral( '/model/graphs' )
makeTab( 'a_soma', '/model/chem/compt0/a[0]' )
makeTab( 'b_soma', '/model/chem/compt0/b[0]' )
makeTab( 'a_apical', '/model/chem/compt0/a[' + str( num ) + ']' )
makeTab( 'b_apical', '/model/chem/compt0/b[' + str( num ) + ']' )
makeTab( 'a_spine', '/model/chem/compt1/a[5]' )
makeTab( 'b_spine', '/model/chem/compt1/b[5]' )
makeTab( 'a_psd', '/model/chem/compt2/a[5]' )
makeTab( 'b_psd', '/model/chem/compt2/b[5]' )
compartment_diameter = compartment_diameter * 1E-6 # Meters
sa = np.pi * compartment_diameter
curved_sa = sa * compartment_length
soma.Rm = RM * curved_sa
soma.Cm = CM / curved_sa
soma.initVm = initVm
soma.Em = Em
# reset simulation
moose.reinit()
# start simulation at 0 nA injection current.
moose.start(0.3)
moose.showfields(soma) # check Vm
soma.inject = -1E-12
# reset simulation
moose.reint()
# start simulation at -1pA injection current.
moose.start(0.3)
moose.showfields(soma)
# Creation of pulse generator.
pulse = moose.PulseGen('pulse')
moose.showfield('pulse')
pulse.delay[0] = 50E-3 # First delay.
pulse.width[0] = 100E03 # Pulse width.
pulse.level[0] = 1E-9 # Pulse amplitude.
pulse.delat[1] = 1E9
def main():
runtime = 1500
displayInterval = 2
makeModel()
dsolve = moose.element('/model/dsolve')
moose.reinit()
#moose.start( runtime ) # Run the model for 10 seconds.
a = moose.element('/model/compartment/a')
b = moose.element('/model/compartment/b')
s = moose.element('/model/compartment/s')
rec = moose.element('/model/compartment/rec')
print moose.showfields(a)
# img = mpimg.imread( 'turingPatternTut.png' )
#imgplot = plt.imshow( img )
#plt.show()
plt.ion()
fig = plt.figure(figsize=(12, 10))
png = fig.add_subplot(211)
# imgplot = plt.imshow( img )
ax = fig.add_subplot(212)
ax.set_ylim(0, 2)
plt.ylabel('Conc (mM)')
plt.xlabel('Position along cylinder (microns)')
pos = numpy.arange(0, a.vec.conc.size, 1)
line1, = ax.plot(pos, a.vec.conc, label='a')
line2, = ax.plot(pos, b.vec.conc, label='b')
line3, = ax.plot(pos, rec.vec.conc, label='rec')
line4, = ax.plot(pos, s.vec.conc, label='s')
timeLabel = plt.text(60, 0.4, 'time = 0')
plt.legend()
fig.canvas.draw()
distS = 1
posPer = [20, 45]
timePer = 1
gaussian = True
storeAvec = []
numStimPoints = 2
print storeAvec
print rec.vec.conc
stimPoint = 0
for ti in range(displayInterval, runtime, displayInterval):
if ti > 150 and ti < 156:
print stimPoint
if gaussian == True:
tempRec = computeTP(timePer, distS)
#for pos in posPer[stimPoint]:
print pos, 'position'
rec.vec[posPer[stimPoint]].conc = rec.vec[
posPer[stimPoint]].conc + tempRec[0]
for i in range(posPer[stimPoint] + 1, len(a.vec.conc)):
rec.vec[i].conc = rec.vec[i].conc + tempRec[
i - posPer[stimPoint]]
if int(posPer[stimPoint] * 2 - i) >= 0:
rec.vec[posPer[stimPoint] + posPer[stimPoint] -
i].conc = rec.vec[
posPer[stimPoint] + posPer[stimPoint] -
i].conc + tempRec[i - posPer[stimPoint]]
rec.vec.conc = rec.vec.conc / 2
stimPoint = stimPoint + 1
else:
#rec.vec[10].conc = 0.07
#rec.vec[30].conc = 0.07
rec.vec[22].conc = 0.08
print 'receptor sum is', sum(rec.vec.conc), max(rec.vec.conc)
plt.figure(10)
plt.plot(rec.vec.conc)
#raw_input()
moose.start(displayInterval)
storeAvec.append(a.vec.conc)
line1.set_ydata(a.vec.conc)
line2.set_ydata(b.vec.conc)
line3.set_ydata(rec.vec.conc * 10)
line4.set_ydata(s.vec.conc)
timeLabel.set_text("time = %d" % ti)
fig.canvas.draw()
print(a.vec.conc)
file = open('c41', 'w')
ty = 0
for tin in a.vec.conc:
tout = str(tin)
ty = ty + 1
file.write(str(ty) + ' ' + tout + '\n')
print("Hit 'enter' to exit")
raw_input()
return storeAvec
def test_mgblock():
"""
Demonstrates the use of MgBlock.
Creates an NMDA channel with MgBlock and another without.
Connects them up to the compartment on one hand, and to a
SynHandler on the other, so as to receive synaptic input.
Delivers two pulses to each receptor, with a small delay in between.
Plots out the conductance change at each receptor and the reslting
membrane potential rise at the compartment.
Note that these NMDA channels do NOT separate out the contributions
due to calcium and other ions. To do this correctly one should use
the GHK object.
"""
model = moose.Neutral('/model')
data = moose.Neutral('/data')
soma = moose.Compartment('/model/soma')
soma.Em = -60e-3
soma.Rm = 1e7
soma.Cm = 1e-9
###################################################
# This is where we create the synapse with MgBlock
#--------------------------------------------------
nmda = moose.SynChan('/model/soma/nmda')
nmda.Gbar = 1e-9
mgblock = moose.MgBlock('/model/soma/mgblock')
mgblock.CMg = 2.0
mgblock.KMg_A = 1/0.33
mgblock.KMg_B = 1/60.0
# The synHandler manages the synapses and their learning rules if any.
synHandler = moose.SimpleSynHandler( '/model/soma/nmda/handler' )
synHandler.synapse.num = 1
moose.connect( synHandler, 'activationOut', nmda, 'activation' )
# MgBlock sits between original channel nmda and the
# compartment. The origChannel receives the channel message from
# the nmda SynChan.
moose.connect(soma, 'VmOut', nmda, 'Vm' )
moose.connect(nmda, 'channelOut', mgblock, 'origChannel')
moose.connect(mgblock, 'channel', soma, 'channel')
# This is for comparing with MgBlock
nmda_noMg = moose.copy(nmda, soma, 'nmda_noMg')
moose.connect( nmda_noMg, 'channel', soma, 'channel')
moose.le( nmda_noMg )
#########################################
# The rest is for experiment setup
spikegen = moose.SpikeGen('/model/spike')
pulse = moose.PulseGen('/model/input')
pulse.delay[0] = 10e-3
pulse.level[0] = 1.0
pulse.width[0] = 50e-3
moose.connect(pulse, 'output', spikegen, 'Vm')
moose.le( synHandler )
#syn = moose.element(synHandler.path + '/synapse' )
syn = synHandler.synapse[0]
syn.delay = simdt * 2
syn.weight = 10
moose.connect(spikegen, 'spikeOut', synHandler.synapse[0], 'addSpike')
moose.le( nmda_noMg )
noMgSyn = moose.element(nmda_noMg.path + '/handler/synapse' )
noMgSyn.delay = 0.01
noMgSyn.weight = 1
moose.connect(spikegen, 'spikeOut', noMgSyn, 'addSpike')
moose.showfields( syn )
moose.showfields( noMgSyn )
Gnmda = moose.Table('/data/Gnmda')
moose.connect(Gnmda, 'requestOut', mgblock, 'getGk')
Gnmda_noMg = moose.Table('/data/Gnmda_noMg')
moose.connect(Gnmda_noMg, 'requestOut', nmda_noMg, 'getGk')
Vm = moose.Table('/data/Vm')
moose.connect(Vm, 'requestOut', soma, 'getVm')
for i in range( 10 ):
moose.setClock( i, simdt )
moose.setClock( Gnmda.tick, plotdt )
print spikegen.dt, Gnmda.dt
moose.reinit()
moose.start( simtime )
t = pylab.linspace(0, simtime*1e3, len(Vm.vector))
pylab.plot(t, (Vm.vector + 0.06) * 1000, label='Vm (mV)')
pylab.plot(t, Gnmda.vector * 1e9, label='Gnmda (nS)')
pylab.plot(t, Gnmda_noMg.vector * 1e9, label='Gnmda no Mg (nS)')
pylab.legend()
#data = pylab.vstack((t, Gnmda.vector, Gnmda_noMg.vector)).transpose()
#pylab.savetxt('mgblock.dat', data)
pylab.show()
def main():
runtime = 1000
displayInterval = 2
makeModel()
dsolve = moose.element('/model/dsolve')
moose.reinit()
#moose.start( runtime ) # Run the model for 10 seconds.
a = moose.element('/model/compartment/a')
b = moose.element('/model/compartment/b')
s = moose.element('/model/compartment/s')
rec = moose.element('/model/compartment/rec')
print moose.showfields(a)
# img = mpimg.imread( 'turingPatternTut.png' )
#imgplot = plt.imshow( img )
#plt.show()
plt.ion()
fig = plt.figure(figsize=(12, 10))
png = fig.add_subplot(211)
# imgplot = plt.imshow( img )
ax = fig.add_subplot(212)
ax.set_ylim(0, 2)
plt.ylabel('Conc (mM)')
plt.xlabel('Position along cylinder (microns)')
pos = numpy.arange(0, a.vec.conc.size, 1)
line1, = ax.plot(pos, a.vec.conc, label='a')
line2, = ax.plot(pos, b.vec.conc, label='b')
line3, = ax.plot(pos, rec.vec.conc, label='rec')
line4, = ax.plot(pos, s.vec.conc, label='s')
timeLabel = plt.text(60, 0.4, 'time = 0')
plt.legend()
fig.canvas.draw()
distS = 10
time = 100
posPer = 25
for ti in range(displayInterval, runtime, displayInterval):
if ti > 100 and ti < 110:
time = time + 0.5
tempRec = computeTP(time, distS)
rec.vec[posPer].conc = tempRec[0]
for i in range(26, len(a.vec.conc)):
rec.vec[i].conc = tempRec[i - 25]
if int(posPer * 2 - i) >= 0:
rec.vec[25 + 25 - i].conc = tempRec[i - 25]
rec.vec.conc = rec.vec.conc / 2
print 'receptor sum is', sum(rec.vec.conc), max(rec.vec.conc)
plt.figure(10)
plt.plot(rec.vec.conc)
moose.start(0.5)
raw_input()
else:
#a.vec[80].conc = 1.2
#b.vec[85].conc *= 1.2
#s.vec[85].conc *= 1.2
#a.vec[80].concInit *= 1.2
#print 'entering the condition'
moose.start(displayInterval)
line1.set_ydata(a.vec.conc)
line2.set_ydata(b.vec.conc)
line3.set_ydata(rec.vec.conc * 10)
line4.set_ydata(s.vec.conc)
timeLabel.set_text("time = %d" % ti)
fig.canvas.draw()
print(a.vec.conc)
file = open('c41', 'w')
ty = 0
for tin in a.vec.conc:
tout = str(tin)
ty = ty + 1
file.write(str(ty) + ' ' + tout + '\n')
print("Hit 'enter' to exit")
raw_input()
def makeModel():
model = moose.Neutral('/model')
# Make neuronal model. It has no channels, just for geometry
cell = moose.loadModel('./spinyNeuron.p', '/model/cell', 'Neutral')
# We don't want the cell to do any calculations. Disable everything.
for i in moose.wildcardFind('/model/cell/##'):
i.tick = -1
# create container for model
model = moose.element('/model')
chem = moose.Neutral('/model/chem')
# The naming of the compartments is dicated by the places that the
# chem model expects to be loaded.
compt0 = moose.NeuroMesh('/model/chem/compt0')
compt0.separateSpines = 1
compt0.geometryPolicy = 'cylinder'
compt1 = moose.SpineMesh('/model/chem/compt1')
moose.connect(compt0, 'spineListOut', compt1, 'spineList', 'OneToOne')
compt2 = moose.PsdMesh('/model/chem/compt2')
moose.connect(compt0, 'psdListOut', compt2, 'psdList', 'OneToOne')
#reacSystem = moose.loadModel( 'simpleOsc.g', '/model/chem', 'ee' )
makeChemModel(compt0, True) # Populate all 3 compts with the chem system.
makeChemModel(compt1, False)
makeChemModel(compt2, True)
compt0.diffLength = 2e-6 # This will be over 100 compartments.
# This is the magic command that configures the diffusion compartments.
compt0.cell = cell
moose.showfields(compt0)
# Build the solvers. No need for diffusion in this version.
ksolve0 = moose.Ksolve('/model/chem/compt0/ksolve')
if useGssa:
ksolve1 = moose.Gsolve('/model/chem/compt1/ksolve')
ksolve2 = moose.Gsolve('/model/chem/compt2/ksolve')
else:
ksolve1 = moose.Ksolve('/model/chem/compt1/ksolve')
ksolve2 = moose.Ksolve('/model/chem/compt2/ksolve')
dsolve0 = moose.Dsolve('/model/chem/compt0/dsolve')
dsolve1 = moose.Dsolve('/model/chem/compt1/dsolve')
dsolve2 = moose.Dsolve('/model/chem/compt2/dsolve')
stoich0 = moose.Stoich('/model/chem/compt0/stoich')
stoich1 = moose.Stoich('/model/chem/compt1/stoich')
stoich2 = moose.Stoich('/model/chem/compt2/stoich')
# Configure solvers
stoich0.compartment = compt0
stoich1.compartment = compt1
stoich2.compartment = compt2
stoich0.ksolve = ksolve0
stoich1.ksolve = ksolve1
stoich2.ksolve = ksolve2
stoich0.dsolve = dsolve0
stoich1.dsolve = dsolve1
stoich2.dsolve = dsolve2
stoich0.path = '/model/chem/compt0/#'
stoich1.path = '/model/chem/compt1/#'
stoich2.path = '/model/chem/compt2/#'
assert (stoich0.numVarPools == 1)
assert (stoich0.numProxyPools == 0)
assert (stoich0.numRates == 1)
assert (stoich1.numVarPools == 1)
assert (stoich1.numProxyPools == 0)
if useGssa:
assert (stoich1.numRates == 2)
assert (stoich2.numRates == 2)
else:
assert (stoich1.numRates == 1)
assert (stoich2.numRates == 1)
assert (stoich2.numVarPools == 1)
assert (stoich2.numProxyPools == 0)
dsolve0.buildNeuroMeshJunctions(dsolve1, dsolve2)
stoich0.buildXreacs(stoich1)
stoich1.buildXreacs(stoich2)
stoich0.filterXreacs()
stoich1.filterXreacs()
stoich2.filterXreacs()
Ca_input_dend = moose.vec('/model/chem/compt0/Ca_input')
print len(Ca_input_dend)
for i in range(60):
Ca_input_dend[3 + i * 3].conc = 2.0
Ca_input_PSD = moose.vec('/model/chem/compt2/Ca_input')
print len(Ca_input_PSD)
for i in range(5):
Ca_input_PSD[2 + i * 2].conc = 1.0
# Create the output tables
num = compt0.numDiffCompts - 1
graphs = moose.Neutral('/model/graphs')
makeTab('Ca_soma', '/model/chem/compt0/Ca[0]')
makeTab('Ca_d1', '/model/chem/compt0/Ca[1]')
makeTab('Ca_d2', '/model/chem/compt0/Ca[2]')
makeTab('Ca_d3', '/model/chem/compt0/Ca[3]')
makeTab('Ca_s3', '/model/chem/compt1/Ca[3]')
makeTab('Ca_s4', '/model/chem/compt1/Ca[4]')
makeTab('Ca_s5', '/model/chem/compt1/Ca[5]')
makeTab('Ca_p3', '/model/chem/compt2/Ca[3]')
makeTab('Ca_p4', '/model/chem/compt2/Ca[4]')
makeTab('Ca_p5', '/model/chem/compt2/Ca[5]')
import moose import rdesigneur as rd rdes = rd.rdesigneur() rdes.buildModel() moose.showfields(rdes.soma)
def test1():
rdes = rd.rdesigneur()
rdes.buildModel()
moose.showfields(rdes.soma)
def main():
cm = ChannelML( {'temperature': 32 })
cm.readChannelMLFromFile( 'CA1_migliore_reference/hd.xml' )
cm.readChannelMLFromFile( 'CA1_migliore_reference/kap.xml' )
cm.readChannelMLFromFile( 'CA1_migliore_reference/kad.xml' )
cm.readChannelMLFromFile( 'CA1_migliore_reference/kdr.xml' )
cm.readChannelMLFromFile( 'CA1_migliore_reference/na3.xml' )
cm.readChannelMLFromFile( 'CA1_migliore_reference/nax.xml' )
if ( len( sys.argv ) < 2 ):
print("Usage: ", sys.argv[0], " filename")
return
# filename = "./Bhavika_swcplusnmlfiles/preliminarily corrected nmlfiles/ascoli+buzsaki/valid/" + sys.argv[1]
filename = sys.argv[1]
moose.Neutral( '/model' )
# Load in the swc file.
cell = moose.loadModel( filename, '/model/ca1' )
for i in moose.wildcardFind( '/library/##' ):
i.tick = -1
chanDistrib = [ \
"EM", "#", "-58e-3", \
"initVm", "#", "-65e-3", \
"RM", "#", "2.8", \
"CM", "#", "0.01", \
"RA", "#", "1.5", \
"RA", "#axon#", "0.5", \
"hd", "#dend#,#apical#", "5e-2*(1+(r*3e4))", \
"kdr", "#", "100", \
"na3", "#soma#,#dend#,#apical#", "250", \
"nax", "#axon#", "1250", \
"kap", "#axon#,#soma#", "300", \
"kap", "#dend#,#apical#", "150*(1+sign(100-r*1e6)) * (1+(r*1e4))", \
"kad", "#dend#,#apical#", "150*(1+sign(r*1e6-100))*(1+r*1e4)", \
]
moose.showfields( cell[0] )
cell[0].channelDistribution = chanDistrib
cell[0].parseChanDistrib()
for i in range( 8 ):
moose.setClock( i, simdt )
hsolve = moose.HSolve( '/model/ca1/hsolve' )
hsolve.dt = simdt
hsolve.target = '/model/ca1/soma'
'''
'''
moose.reinit()
makePlot( cell[0] )
# Now we set up the display
moose.le( '/model/ca1/soma' )
soma = moose.element( '/model/ca1/soma' )
kap = moose.element( '/model/ca1/soma/kap' )
graphs = moose.Neutral( '/graphs' )
vtab = moose.Table( '/graphs/vtab' )
moose.connect( vtab, 'requestOut', soma, 'getVm' )
kaptab = moose.Table( '/graphs/kaptab' )
moose.connect( kaptab, 'requestOut', kap, 'getGk' )
compts = moose.wildcardFind( "/model/ca1/#[ISA=CompartmentBase]" )
'''
for i in compts:
if moose.exists( i.path + '/Na' ):
print i.path, moose.element( i.path + '/Na' ).Gbar, \
moose.element( i.path + '/K_DR' ).Gbar, \
i.Rm, i.Ra, i.Cm
'''
'''
Na = moose.wildcardFind( '/model/ca1/#/Na#' )
print Na
Na2 = []
for i in compts:
if ( moose.exists( i.path + '/NaF2' ) ):
Na2.append( moose.element( i.path + '/NaF2' ) )
if ( moose.exists( i.path + '/NaPF_SS' ) ):
Na2.append( moose.element( i.path + '/NaPF_SS' ) )
ecomptPath = map( lambda x : x.path, compts )
print "Na placed in ", len( Na ), len( Na2 ), " out of ", len( compts ), " compts."
'''
compts[0].inject = inject
ecomptPath = [x.path for x in compts]
# Graphics stuff here.
app = QtGui.QApplication(sys.argv)
morphology = moogli.read_morphology_from_moose(name = "", path = "/model/ca1")
morphology.create_group( "group_all", ecomptPath, -0.08, 0.02, \
[0.0, 0.0, 1.0, 1.0], [1.0, 0.0, 0.0, 0.1] )
viewer = moogli.DynamicMorphologyViewerWidget(morphology)
def callback( morphology, viewer ):
moose.start( frameRunTime )
Vm = [moose.element( x ).Vm for x in compts]
morphology.set_color( "group_all", Vm )
currTime = moose.element( '/clock' ).currentTime
#print currTime, compts[0].Vm
if ( currTime < runtime ):
return True
return False
viewer.set_callback( callback, idletime = 0 )
viewer.showMaximized()
viewer.show()
app.exec_()
t = numpy.arange( 0, runtime, vtab.dt )
fig = plt.figure()
p1 = fig.add_subplot(311)
p2 = fig.add_subplot(312)
p2.plot( t, vtab.vector, label = 'Vm Soma' )
p2.legend()
p3 = fig.add_subplot(313)
p3.plot( t, kaptab.vector, label = 'kap Soma' )
p3.legend()
plt.show()
def test_mgblock():
model = moose.Neutral('/model')
data = moose.Neutral('/data')
soma = moose.Compartment('/model/soma')
soma.Em = -60e-3
soma.Rm = 1e7
soma.Cm = 1e-9
###################################################
# This is where we create the synapse with MgBlock
#--------------------------------------------------
nmda = moose.SynChan('/model/soma/nmda')
nmda.Gbar = 1e-9
mgblock = moose.MgBlock('/model/soma/mgblock')
mgblock.CMg = 2.0
mgblock.KMg_A = 1 / 0.33
mgblock.KMg_B = 1 / 60.0
# The synHandler manages the synapses and their learning rules if any.
synHandler = moose.SimpleSynHandler('/model/soma/nmda/handler')
synHandler.synapse.num = 1
moose.connect(synHandler, 'activationOut', nmda, 'activation')
# MgBlock sits between original channel nmda and the
# compartment. The origChannel receives the channel message from
# the nmda SynChan.
moose.connect(soma, 'VmOut', nmda, 'Vm')
moose.connect(nmda, 'channelOut', mgblock, 'origChannel')
moose.connect(mgblock, 'channel', soma, 'channel')
# This is for comparing with MgBlock
nmda_noMg = moose.copy(nmda, soma, 'nmda_noMg')
moose.connect(nmda_noMg, 'channel', soma, 'channel')
moose.le(nmda_noMg)
#########################################
# The rest is for experiment setup
spikegen = moose.SpikeGen('/model/spike')
pulse = moose.PulseGen('/model/input')
pulse.delay[0] = 10e-3
pulse.level[0] = 1.0
pulse.width[0] = 50e-3
moose.connect(pulse, 'output', spikegen, 'Vm')
moose.le(synHandler)
#syn = moose.element(synHandler.path + '/synapse' )
syn = synHandler.synapse[0]
syn.delay = simdt * 2
syn.weight = 10
moose.connect(spikegen, 'spikeOut', synHandler.synapse[0], 'addSpike')
moose.le(nmda_noMg)
noMgSyn = moose.element(nmda_noMg.path + '/handler/synapse')
noMgSyn.delay = 0.01
noMgSyn.weight = 1
moose.connect(spikegen, 'spikeOut', noMgSyn, 'addSpike')
moose.showfields(syn)
moose.showfields(noMgSyn)
Gnmda = moose.Table('/data/Gnmda')
moose.connect(Gnmda, 'requestOut', mgblock, 'getGk')
Gnmda_noMg = moose.Table('/data/Gnmda_noMg')
moose.connect(Gnmda_noMg, 'requestOut', nmda_noMg, 'getGk')
Vm = moose.Table('/data/Vm')
moose.connect(Vm, 'requestOut', soma, 'getVm')
for i in range(10):
moose.setClock(i, simdt)
moose.setClock(Gnmda.tick, plotdt)
print((spikegen.dt, Gnmda.dt))
moose.reinit()
moose.start(simtime)
t = pylab.linspace(0, simtime * 1e3, len(Vm.vector))
pylab.plot(t, (Vm.vector + 0.06) * 1000, label='Vm (mV)')
pylab.plot(t, Gnmda.vector * 1e9, label='Gnmda (nS)')
pylab.plot(t, Gnmda_noMg.vector * 1e9, label='Gnmda no Mg (nS)')
pylab.legend()
#data = pylab.vstack((t, Gnmda.vector, Gnmda_noMg.vector)).transpose()
#pylab.savetxt('mgblock.dat', data)
pylab.show()
