def main(): time_start = ph.start_timing() # Set print options for numpy np.set_printoptions(precision=3) # Read input input_parser = InputArgparser( description="Volumetric MRI reconstruction framework to reconstruct " "an isotropic, high-resolution 3D volume from multiple " "motion-corrected (or static) stacks of low-resolution slices.", ) input_parser.add_dir_input() input_parser.add_filenames() input_parser.add_image_selection() input_parser.add_dir_output(required=True) input_parser.add_prefix_output(default="SRR_") input_parser.add_suffix_mask(default="_mask") input_parser.add_target_stack_index(default=0) input_parser.add_extra_frame_target(default=10) input_parser.add_isotropic_resolution(default=None) input_parser.add_reconstruction_space(default=None) input_parser.add_minimizer(default="lsmr") input_parser.add_iter_max(default=10) input_parser.add_reconstruction_type(default="TK1L2") input_parser.add_data_loss(default="linear") input_parser.add_data_loss_scale(default=1) input_parser.add_alpha(default=0.02 # TK1L2 # default=0.006 #TVL2, HuberL2 ) input_parser.add_rho(default=0.5) input_parser.add_tv_solver(default="PD") input_parser.add_pd_alg_type(default="ALG2") input_parser.add_iterations(default=15) input_parser.add_subfolder_comparison() input_parser.add_provide_comparison(default=0) input_parser.add_log_script_execution(default=1) input_parser.add_verbose(default=0) args = input_parser.parse_args() input_parser.print_arguments(args) # Write script execution call if args.log_script_execution: input_parser.write_performed_script_execution( os.path.abspath(__file__)) # --------------------------------Read Data-------------------------------- ph.print_title("Read Data") # Neither '--dir-input' nor '--filenames' was specified if args.filenames is not None and args.dir_input is not None: raise IOError("Provide input by either '--dir-input' or '--filenames' " "but not both together") # '--dir-input' specified elif args.dir_input is not None: data_reader = dr.ImageSlicesDirectoryReader( path_to_directory=args.dir_input, suffix_mask=args.suffix_mask, image_selection=args.image_selection) # '--filenames' specified elif args.filenames is not None: data_reader = dr.MultipleImagesReader(args.filenames, suffix_mask=args.suffix_mask) else: raise IOError("Provide input by either '--dir-input' or '--filenames'") if args.reconstruction_type not in ["TK1L2", "TVL2", "HuberL2"]: raise IOError("Reconstruction type unknown") data_reader.read_data() stacks = data_reader.get_data() ph.print_info("%d input stacks read for further processing" % len(stacks)) # Reconstruction space is given isotropically resampled target stack if args.reconstruction_space is None: recon0 = \ stacks[args.target_stack_index].get_isotropically_resampled_stack( resolution=args.isotropic_resolution, extra_frame=args.extra_frame_target) # Reconstruction space was provided by user else: recon0 = st.Stack.from_filename(args.reconstruction_space, extract_slices=False) # Change resolution for isotropic resolution if provided by user if args.isotropic_resolution is not None: recon0 = recon0.get_isotropically_resampled_stack( args.isotropic_resolution) # Use image information of selected target stack as recon0 serves # as initial value for reconstruction recon0 = \ stacks[args.target_stack_index].get_resampled_stack(recon0.sitk) recon0 = recon0.get_stack_multiplied_with_mask() if args.reconstruction_type in ["TVL2", "HuberL2"]: ph.print_title("Compute Initial value for %s" % args.reconstruction_type) SRR0 = tk.TikhonovSolver( stacks=stacks, reconstruction=recon0, alpha=args.alpha, iter_max=args.iter_max, reg_type="TK1", minimizer=args.minimizer, data_loss=args.data_loss, data_loss_scale=args.data_loss_scale, # verbose=args.verbose, ) SRR0.run() recon = SRR0.get_reconstruction() recon.set_filename(SRR0.get_setting_specific_filename(args.prefix_output)) recon.write(args.dir_output) # List to store SRRs recons = [] for i in range(0, len(stacks)): recons.append(stacks[i]) recons.insert(0, recon) if args.reconstruction_type in ["TVL2", "HuberL2"]: ph.print_title("Compute %s reconstruction" % args.reconstruction_type) if args.tv_solver == "ADMM": SRR = admm.ADMMSolver( stacks=stacks, reconstruction=st.Stack.from_stack(SRR0.get_reconstruction()), minimizer=args.minimizer, alpha=args.alpha, iter_max=args.iter_max, rho=args.rho, data_loss=args.data_loss, iterations=args.iterations, verbose=args.verbose, ) SRR.run() recon = SRR.get_reconstruction() recon.set_filename( SRR.get_setting_specific_filename(args.prefix_output)) recons.insert(0, recon) recon.write(args.dir_output) else: SRR = pd.PrimalDualSolver( stacks=stacks, reconstruction=st.Stack.from_stack(SRR0.get_reconstruction()), minimizer=args.minimizer, alpha=args.alpha, iter_max=args.iter_max, iterations=args.iterations, alg_type=args.pd_alg_type, reg_type="TV" if args.reconstruction_type == "TVL2" else "huber", data_loss=args.data_loss, verbose=args.verbose, ) SRR.run() recon = SRR.get_reconstruction() recon.set_filename( SRR.get_setting_specific_filename(args.prefix_output)) recons.insert(0, recon) recon.write(args.dir_output) if args.verbose and not args.provide_comparison: sitkh.show_stacks(recons) # Show SRR together with linearly resampled input data. # Additionally, a script is generated to open files if args.provide_comparison: sitkh.show_stacks( recons, show_comparison_file=args.provide_comparison, dir_output=os.path.join(args.dir_output, args.subfolder_comparison), ) ph.print_line_separator() elapsed_time = ph.stop_timing(time_start) ph.print_title("Summary") print("Computational Time for Volumetric Reconstruction: %s" % (elapsed_time)) return 0
def main(): time_start = ph.start_timing() # Set print options for numpy np.set_printoptions(precision=3) # Read input input_parser = InputArgparser( description="Volumetric MRI reconstruction framework to reconstruct " "an isotropic, high-resolution 3D volume from multiple stacks of 2D " "slices with motion correction. The resolution of the computed " "Super-Resolution Reconstruction (SRR) is given by the in-plane " "spacing of the selected target stack. A region of interest can be " "specified by providing a mask for the selected target stack. Only " "this region will then be reconstructed by the SRR algorithm which " "can substantially reduce the computational time.", ) input_parser.add_dir_input() input_parser.add_filenames() input_parser.add_dir_output(required=True) input_parser.add_suffix_mask(default="_mask") input_parser.add_target_stack_index(default=0) input_parser.add_search_angle(default=90) input_parser.add_multiresolution(default=0) input_parser.add_shrink_factors(default=[2, 1]) input_parser.add_smoothing_sigmas(default=[1, 0]) input_parser.add_sigma(default=0.9) input_parser.add_reconstruction_type(default="TK1L2") input_parser.add_iterations(default=15) input_parser.add_alpha(default=0.02) input_parser.add_alpha_first(default=0.05) input_parser.add_iter_max(default=10) input_parser.add_iter_max_first(default=5) input_parser.add_dilation_radius(default=3) input_parser.add_extra_frame_target(default=10) input_parser.add_bias_field_correction(default=0) input_parser.add_intensity_correction(default=0) input_parser.add_isotropic_resolution(default=None) input_parser.add_log_script_execution(default=1) input_parser.add_subfolder_motion_correction() input_parser.add_provide_comparison(default=0) input_parser.add_subfolder_comparison() input_parser.add_write_motion_correction(default=1) input_parser.add_verbose(default=0) input_parser.add_two_step_cycles(default=3) input_parser.add_use_masks_srr(default=1) input_parser.add_boundary_stacks(default=[10, 10, 0]) input_parser.add_reference() input_parser.add_reference_mask() args = input_parser.parse_args() input_parser.print_arguments(args) # Write script execution call if args.log_script_execution: input_parser.write_performed_script_execution( os.path.abspath(__file__)) # Use FLIRT for volume-to-volume reg. step. Otherwise, RegAladin is used. use_flirt_for_v2v_registration = True # --------------------------------Read Data-------------------------------- ph.print_title("Read Data") # Neither '--dir-input' nor '--filenames' was specified if args.filenames is not None and args.dir_input is not None: raise IOError("Provide input by either '--dir-input' or '--filenames' " "but not both together") # '--dir-input' specified elif args.dir_input is not None: data_reader = dr.ImageDirectoryReader(args.dir_input, suffix_mask=args.suffix_mask) # '--filenames' specified elif args.filenames is not None: data_reader = dr.MultipleImagesReader(args.filenames, suffix_mask=args.suffix_mask) else: raise IOError("Provide input by either '--dir-input' or '--filenames'") if len(args.boundary_stacks) is not 3: raise IOError( "Provide exactly three values for '--boundary-stacks' to define " "cropping in i-, j-, and k-dimension of the input stacks") data_reader.read_data() stacks = data_reader.get_data() ph.print_info("%d input stacks read for further processing" % len(stacks)) if all(s.is_unity_mask() is True for s in stacks): ph.print_warning("No mask is provided! " "Generated reconstruction space may be very big!") # ---------------------------Data Preprocessing--------------------------- ph.print_title("Data Preprocessing") segmentation_propagator = segprop.SegmentationPropagation( # registration_method=regflirt.FLIRT(use_verbose=args.verbose), dilation_radius=args.dilation_radius, dilation_kernel="Ball", ) data_preprocessing = dp.DataPreprocessing( stacks=stacks, segmentation_propagator=segmentation_propagator, use_cropping_to_mask=True, use_N4BiasFieldCorrector=args.bias_field_correction, use_intensity_correction=args.intensity_correction, target_stack_index=args.target_stack_index, boundary_i=args.boundary_stacks[0], boundary_j=args.boundary_stacks[1], boundary_k=args.boundary_stacks[2], unit="mm", ) data_preprocessing.run() time_data_preprocessing = data_preprocessing.get_computational_time() # Get preprocessed stacks stacks = data_preprocessing.get_preprocessed_stacks() # Define reference/target stack for registration and reconstruction if args.reference is not None: reference = st.Stack.from_filename(file_path=args.reference, file_path_mask=args.reference_mask, extract_slices=False) else: reference = st.Stack.from_stack(stacks[args.target_stack_index]) # ------------------------Volume-to-Volume Registration-------------------- if args.two_step_cycles > 0: # Define search angle ranges for FLIRT in all three dimensions search_angles = [ "-searchr%s -%d %d" % (x, args.search_angle, args.search_angle) for x in ["x", "y", "z"] ] search_angles = (" ").join(search_angles) if use_flirt_for_v2v_registration: vol_registration = regflirt.FLIRT( registration_type="Rigid", use_fixed_mask=True, use_moving_mask=True, options=search_angles, use_verbose=False, ) else: vol_registration = niftyreg.RegAladin( registration_type="Rigid", use_fixed_mask=True, use_moving_mask=True, use_verbose=False, ) v2vreg = pipeline.VolumeToVolumeRegistration( stacks=stacks, reference=reference, registration_method=vol_registration, verbose=args.verbose, ) v2vreg.run() stacks = v2vreg.get_stacks() time_registration = v2vreg.get_computational_time() else: time_registration = ph.get_zero_time() # ---------------------------Create first volume--------------------------- time_tmp = ph.start_timing() # Isotropic resampling to define HR target space ph.print_title("Reconstruction Space Generation") HR_volume = reference.get_isotropically_resampled_stack( resolution=args.isotropic_resolution) ph.print_info( "Isotropic reconstruction space with %g mm resolution is created" % HR_volume.sitk.GetSpacing()[0]) if args.reference is None: # Create joint image mask in target space joint_image_mask_builder = imb.JointImageMaskBuilder( stacks=stacks, target=HR_volume, dilation_radius=1, ) joint_image_mask_builder.run() HR_volume = joint_image_mask_builder.get_stack() ph.print_info("Isotropic reconstruction space is centered around " "joint stack masks. ") # Crop to space defined by mask (plus extra margin) HR_volume = HR_volume.get_cropped_stack_based_on_mask( boundary_i=args.extra_frame_target, boundary_j=args.extra_frame_target, boundary_k=args.extra_frame_target, unit="mm", ) # Scattered Data Approximation to get first estimate of HR volume ph.print_title("First Estimate of HR Volume") SDA = sda.ScatteredDataApproximation(stacks, HR_volume, sigma=args.sigma) SDA.run() HR_volume = SDA.get_reconstruction() time_reconstruction = ph.stop_timing(time_tmp) if args.verbose: tmp = list(stacks) tmp.insert(0, HR_volume) sitkh.show_stacks(tmp, segmentation=HR_volume) # ----------------Two-step Slice-to-Volume Registration SRR---------------- SRR = tk.TikhonovSolver( stacks=stacks, reconstruction=HR_volume, reg_type="TK1", minimizer="lsmr", alpha=args.alpha_first, iter_max=args.iter_max_first, verbose=True, use_masks=args.use_masks_srr, ) if args.two_step_cycles > 0: registration = regsitk.SimpleItkRegistration( moving=HR_volume, use_fixed_mask=True, use_moving_mask=True, use_verbose=args.verbose, interpolator="Linear", metric="Correlation", use_multiresolution_framework=args.multiresolution, shrink_factors=args.shrink_factors, smoothing_sigmas=args.smoothing_sigmas, initializer_type="SelfGEOMETRY", optimizer="ConjugateGradientLineSearch", optimizer_params={ "learningRate": 1, "numberOfIterations": 100, "lineSearchUpperLimit": 2, }, scales_estimator="Jacobian", ) two_step_s2v_reg_recon = \ pipeline.TwoStepSliceToVolumeRegistrationReconstruction( stacks=stacks, reference=HR_volume, registration_method=registration, reconstruction_method=SRR, cycles=args.two_step_cycles, alpha_range=[args.alpha_first, args.alpha], verbose=args.verbose, ) two_step_s2v_reg_recon.run() HR_volume_iterations = \ two_step_s2v_reg_recon.get_iterative_reconstructions() time_registration += \ two_step_s2v_reg_recon.get_computational_time_registration() time_reconstruction += \ two_step_s2v_reg_recon.get_computational_time_reconstruction() else: HR_volume_iterations = [] # Write motion-correction results if args.write_motion_correction: for stack in stacks: stack.write( os.path.join(args.dir_output, args.subfolder_motion_correction), write_mask=True, write_slices=True, write_transforms=True, suffix_mask=args.suffix_mask, ) # ------------------Final Super-Resolution Reconstruction------------------ ph.print_title("Final Super-Resolution Reconstruction") if args.reconstruction_type in ["TVL2", "HuberL2"]: SRR = pd.PrimalDualSolver( stacks=stacks, reconstruction=HR_volume, reg_type="TV" if args.reconstruction_type == "TVL2" else "huber", iterations=args.iterations, ) else: SRR = tk.TikhonovSolver( stacks=stacks, reconstruction=HR_volume, reg_type="TK1" if args.reconstruction_type == "TK1L2" else "TK0", use_masks=args.use_masks_srr, ) SRR.set_alpha(args.alpha) SRR.set_iter_max(args.iter_max) SRR.set_verbose(True) SRR.run() time_reconstruction += SRR.get_computational_time() elapsed_time_total = ph.stop_timing(time_start) # Write SRR result HR_volume_final = SRR.get_reconstruction() HR_volume_final.set_filename(SRR.get_setting_specific_filename()) HR_volume_final.write(args.dir_output, write_mask=True, suffix_mask=args.suffix_mask) HR_volume_iterations.insert(0, HR_volume_final) for stack in stacks: HR_volume_iterations.append(stack) if args.verbose and not args.provide_comparison: sitkh.show_stacks(HR_volume_iterations, segmentation=HR_volume) # HR_volume_final.show() # Show SRR together with linearly resampled input data. # Additionally, a script is generated to open files if args.provide_comparison: sitkh.show_stacks( HR_volume_iterations, segmentation=HR_volume, show_comparison_file=args.provide_comparison, dir_output=os.path.join(args.dir_output, args.subfolder_comparison), ) # Summary ph.print_title("Summary") print("Computational Time for Data Preprocessing: %s" % (time_data_preprocessing)) print("Computational Time for Registrations: %s" % (time_registration)) print("Computational Time for Reconstructions: %s" % (time_reconstruction)) print("Computational Time for Entire Reconstruction Pipeline: %s" % (elapsed_time_total)) ph.print_line_separator() return 0
def main(): time_start = ph.start_timing() # Set print options for numpy np.set_printoptions(precision=3) # Read input input_parser = InputArgparser( description="Script to study reconstruction parameters and their " "impact on the volumetric reconstruction quality.", ) input_parser.add_dir_input() input_parser.add_filenames() input_parser.add_image_selection() input_parser.add_dir_output(required=True) input_parser.add_suffix_mask(default="_mask") input_parser.add_reconstruction_space() input_parser.add_reference( help="Path to reference NIfTI image file. If given the volumetric " "reconstructed is performed in this physical space. " "Either a reconstruction space or a reference must be provided", required=False) input_parser.add_reference_mask(default=None) input_parser.add_study_name() input_parser.add_reconstruction_type(default="TK1L2") input_parser.add_measures(default=["PSNR", "RMSE", "SSIM", "NCC", "NMI"]) input_parser.add_tv_solver(default="PD") input_parser.add_iterations(default=50) input_parser.add_rho(default=0.1) input_parser.add_iter_max(default=10) input_parser.add_minimizer(default="lsmr") input_parser.add_alpha(default=0.01) input_parser.add_data_loss(default="linear") input_parser.add_data_loss_scale(default=1) input_parser.add_log_script_execution(default=1) input_parser.add_verbose(default=1) # Range for parameter sweeps input_parser.add_alpha_range(default=[0.001, 0.05, 20]) # TK1L2 # input_parser.add_alpha_range(default=[0.001, 0.003, 10]) # TVL2, HuberL2 input_parser.add_data_losses( # default=["linear", "arctan"] ) input_parser.add_data_loss_scale_range( # default=[0.1, 1.5, 2] ) args = input_parser.parse_args() input_parser.print_arguments(args) if args.reference is None and args.reconstruction_space is None: raise IOError("Either reference (--reference) or reconstruction space " "(--reconstruction-space) must be provided.") # Write script execution call if args.log_script_execution: input_parser.write_performed_script_execution( os.path.abspath(__file__)) # --------------------------------Read Data-------------------------------- ph.print_title("Read Data") # Neither '--dir-input' nor '--filenames' was specified if args.filenames is not None and args.dir_input is not None: raise IOError( "Provide input by either '--dir-input' or '--filenames' " "but not both together") # '--dir-input' specified elif args.dir_input is not None: data_reader = dr.ImageSlicesDirectoryReader( path_to_directory=args.dir_input, suffix_mask=args.suffix_mask, image_selection=args.image_selection) # '--filenames' specified elif args.filenames is not None: data_reader = dr.MultipleImagesReader( args.filenames, suffix_mask=args.suffix_mask) else: raise IOError( "Provide input by either '--dir-input' or '--filenames'") data_reader.read_data() stacks = data_reader.get_data() ph.print_info("%d input stacks read for further processing" % len(stacks)) if args.reference is not None: reference = st.Stack.from_filename( file_path=args.reference, file_path_mask=args.reference_mask, extract_slices=False) reconstruction_space = stacks[0].get_resampled_stack(reference.sitk) reconstruction_space = \ reconstruction_space.get_stack_multiplied_with_mask() x_ref = sitk.GetArrayFromImage(reference.sitk).flatten() x_ref_mask = sitk.GetArrayFromImage(reference.sitk_mask).flatten() else: reconstruction_space = st.Stack.from_filename( file_path=args.reconstruction_space, extract_slices=False) reconstruction_space = stacks[0].get_resampled_stack( reconstruction_space.sitk) reconstruction_space = \ reconstruction_space.get_stack_multiplied_with_mask() x_ref = None x_ref_mask = None # ----------------------------Set Up Parameters---------------------------- parameters = {} parameters["alpha"] = np.linspace( args.alpha_range[0], args.alpha_range[1], int(args.alpha_range[2])) if args.data_losses is not None: parameters["data_loss"] = args.data_losses if args.data_loss_scale_range is not None: parameters["data_loss_scale"] = np.linspace( args.data_loss_scale_range[0], args.data_loss_scale_range[1], int(args.data_loss_scale_range[2])) # --------------------------Set Up Parameter Study------------------------- if args.study_name is None: name = args.reconstruction_type else: name = args.study_name reconstruction_info = { "shape": reconstruction_space.sitk.GetSize()[::-1], "origin": reconstruction_space.sitk.GetOrigin(), "spacing": reconstruction_space.sitk.GetSpacing(), "direction": reconstruction_space.sitk.GetDirection(), } # Create Tikhonov solver from which all information can be extracted # (also for other reconstruction types) tmp = tk.TikhonovSolver( stacks=stacks, reconstruction=reconstruction_space, alpha=args.alpha, iter_max=args.iter_max, data_loss=args.data_loss, data_loss_scale=args.data_loss_scale, reg_type="TK1", minimizer=args.minimizer, verbose=args.verbose, ) solver = tmp.get_solver() parameter_study_interface = \ deconv_interface.DeconvolutionParameterStudyInterface( A=solver.get_A(), A_adj=solver.get_A_adj(), D=solver.get_B(), D_adj=solver.get_B_adj(), b=solver.get_b(), x0=solver.get_x0(), alpha=solver.get_alpha(), x_scale=solver.get_x_scale(), data_loss=solver.get_data_loss(), data_loss_scale=solver.get_data_loss_scale(), iter_max=solver.get_iter_max(), minimizer=solver.get_minimizer(), iterations=args.iterations, measures=args.measures, dimension=3, L2=16./reconstruction_space.sitk.GetSpacing()[0]**2, reconstruction_type=args.reconstruction_type, rho=args.rho, dir_output=args.dir_output, parameters=parameters, name=name, reconstruction_info=reconstruction_info, x_ref=x_ref, x_ref_mask=x_ref_mask, tv_solver=args.tv_solver, verbose=args.verbose, ) parameter_study_interface.set_up_parameter_study() parameter_study = parameter_study_interface.get_parameter_study() # Run parameter study parameter_study.run() print("\nComputational time for Deconvolution Parameter Study %s: %s" % (name, parameter_study.get_computational_time())) return 0
def main(): time_start = ph.start_timing() np.set_printoptions(precision=3) input_parser = InputArgparser( description="Perform Bias Field correction on images based on N4ITK.", ) input_parser.add_filenames(required=True) input_parser.add_dir_output(required=True) input_parser.add_suffix_mask(default="_mask") input_parser.add_prefix_output(default="N4ITK_") input_parser.add_option( option_string="--convergence-threshold", type=float, help="Specify the convergence threshold.", default=1e-6, ) input_parser.add_option( option_string="--spline-order", type=int, help="Specify the spline order defining the bias field estimate.", default=3, ) input_parser.add_option( option_string="--wiener-filter-noise", type=float, help="Specify the noise estimate defining the Wiener filter.", default=0.11, ) input_parser.add_option( option_string="--bias-field-fwhm", type=float, help="Specify the full width at half maximum parameter characterizing " "the width of the Gaussian deconvolution.", default=0.15, ) input_parser.add_log_script_execution(default=1) input_parser.add_verbose(default=0) args = input_parser.parse_args() input_parser.print_arguments(args) # Write script execution call if args.log_script_execution: input_parser.write_performed_script_execution( os.path.abspath(__file__)) # Read data data_reader = dr.MultipleImagesReader(args.filenames, suffix_mask=args.suffix_mask) data_reader.read_data() stacks = data_reader.get_data() # Perform Bias Field Correction ph.print_title("Perform Bias Field Correction") bias_field_corrector = n4itk.N4BiasFieldCorrection( convergence_threshold=args.convergence_threshold, spline_order=args.spline_order, wiener_filter_noise=args.wiener_filter_noise, bias_field_fwhm=args.bias_field_fwhm, prefix_corrected=args.prefix_output, ) stacks_corrected = [None] * len(stacks) for i, stack in enumerate(stacks): ph.print_info("Image %d/%d: N4ITK Bias Field Correction ... " % (i + 1, len(stacks)), newline=False) bias_field_corrector.set_stack(stack) bias_field_corrector.run_bias_field_correction() stacks_corrected[i] = \ bias_field_corrector.get_bias_field_corrected_stack() print("done") ph.print_info("Image %d/%d: Computational time = %s" % (i + 1, len(stacks), bias_field_corrector.get_computational_time())) # Write Data stacks_corrected[i].write(args.dir_output, write_mask=True, suffix_mask=args.suffix_mask) if args.verbose: sitkh.show_stacks([stacks[i], stacks_corrected[i]], segmentation=stacks[i]) elapsed_time = ph.stop_timing(time_start) ph.print_title("Summary") print("Computational Time for Bias Field Correction(s): %s" % (elapsed_time)) return 0
def main(): time_start = ph.start_timing() np.set_printoptions(precision=3) input_parser = InputArgparser( description="Perform (linear) intensity correction across " "stacks/images given a reference stack/image", ) input_parser.add_filenames(required=True) input_parser.add_dir_output(required=True) input_parser.add_reference(required=True) input_parser.add_suffix_mask(default="_mask") input_parser.add_search_angle(default=180) input_parser.add_prefix_output(default="IC_") input_parser.add_log_script_execution(default=1) input_parser.add_option( option_string="--registration", type=int, help="Turn on/off registration from image to reference prior to " "intensity correction.", default=0) input_parser.add_verbose(default=0) args = input_parser.parse_args() input_parser.print_arguments(args) # Write script execution call if args.log_script_execution: input_parser.write_performed_script_execution( os.path.abspath(__file__)) if args.reference in args.filenames: args.filenames.remove(args.reference) # Read data data_reader = dr.MultipleImagesReader(args.filenames, suffix_mask=args.suffix_mask, extract_slices=False) data_reader.read_data() stacks = data_reader.get_data() data_reader = dr.MultipleImagesReader([args.reference], suffix_mask=args.suffix_mask, extract_slices=False) data_reader.read_data() reference = data_reader.get_data()[0] if args.registration: # Define search angle ranges for FLIRT in all three dimensions search_angles = [ "-searchr%s -%d %d" % (x, args.search_angle, args.search_angle) for x in ["x", "y", "z"] ] search_angles = (" ").join(search_angles) registration = regflirt.FLIRT( moving=reference, registration_type="Rigid", use_fixed_mask=True, use_moving_mask=True, options=search_angles, use_verbose=False, ) # Perform Intensity Correction ph.print_title("Perform Intensity Correction") intensity_corrector = ic.IntensityCorrection( use_reference_mask=True, use_individual_slice_correction=False, prefix_corrected=args.prefix_output, use_verbose=False, ) stacks_corrected = [None] * len(stacks) for i, stack in enumerate(stacks): if args.registration: ph.print_info("Image %d/%d: Registration ... " % (i + 1, len(stacks)), newline=False) registration.set_fixed(stack) registration.run() transform_sitk = registration.get_registration_transform_sitk() stack.update_motion_correction(transform_sitk) print("done") ph.print_info("Image %d/%d: Intensity Correction ... " % (i + 1, len(stacks)), newline=False) ref = reference.get_resampled_stack(stack.sitk) ref = st.Stack.from_sitk_image(image_sitk=ref.sitk, image_sitk_mask=stack.sitk_mask * ref.sitk_mask, filename=reference.get_filename()) intensity_corrector.set_stack(stack) intensity_corrector.set_reference(ref) intensity_corrector.run_linear_intensity_correction() # intensity_corrector.run_affine_intensity_correction() stacks_corrected[i] = \ intensity_corrector.get_intensity_corrected_stack() print("done (c1 = %g) " % intensity_corrector.get_intensity_correction_coefficients()) # Write Data stacks_corrected[i].write(args.dir_output, write_mask=True, suffix_mask=args.suffix_mask) if args.verbose: sitkh.show_stacks( [ reference, stacks_corrected[i], # stacks[i], ], segmentation=stacks_corrected[i]) # ph.pause() # Write reference too (although not intensity corrected) reference.write(args.dir_output, filename=args.prefix_output + reference.get_filename(), write_mask=True, suffix_mask=args.suffix_mask) elapsed_time = ph.stop_timing(time_start) ph.print_title("Summary") print("Computational Time for Intensity Correction(s): %s" % (elapsed_time)) return 0
def main(): time_start = ph.start_timing() np.set_printoptions(precision=3) input_parser = InputArgparser( description="Run reconstruction pipeline including " "(i) preprocessing (bias field correction + intensity correction), " "(ii) volumetric reconstruction in subject space, " "and (iii) volumetric reconstruction in template space.", ) input_parser.add_dir_input(required=True) input_parser.add_dir_mask(required=True) input_parser.add_dir_output(required=True) input_parser.add_suffix_mask(default="_mask") input_parser.add_target_stack(required=False) input_parser.add_alpha(default=0.01) input_parser.add_verbose(default=0) input_parser.add_gestational_age(required=False) input_parser.add_prefix_output(default="") input_parser.add_search_angle(default=180) input_parser.add_multiresolution(default=0) input_parser.add_log_script_execution(default=1) input_parser.add_dir_input_templates(default=DIR_TEMPLATES) input_parser.add_isotropic_resolution() input_parser.add_reference() input_parser.add_reference_mask() input_parser.add_bias_field_correction(default=1) input_parser.add_intensity_correction(default=1) input_parser.add_iter_max(default=10) input_parser.add_two_step_cycles(default=3) input_parser.add_option( option_string="--run-recon-subject-space", type=int, help="Turn on/off reconstruction in subject space", default=1) input_parser.add_option( option_string="--run-recon-template-space", type=int, help="Turn on/off reconstruction in template space", default=1) input_parser.add_option( option_string="--run-data-vs-simulated-data", type=int, help="Turn on/off comparison of data vs data simulated from the " "obtained volumetric reconstruction", default=1) input_parser.add_outlier_rejection(default=0) input_parser.add_use_robust_registration(default=0) args = input_parser.parse_args() input_parser.print_arguments(args) # Write script execution call if args.log_script_execution: input_parser.write_performed_script_execution( os.path.abspath(__file__)) dir_output_recon_subject_space = os.path.join( args.dir_output, "recon_subject_space") dir_output_recon_template_space = os.path.join( args.dir_output, "recon_template_space") dir_output_data_vs_simulatd_data = os.path.join( args.dir_output, "data_vs_simulated_data") # if args.run_recon_template_space and args.gestational_age is None: # raise IOError("Gestational age must be set in order to pick the " # "right template") # get input stack names files = os.listdir(args.dir_input) input_files = [] mask_files = [] for file in files: if (".nii" in file): input_files.append("{0:}/{1:}".format(args.dir_input, file)) file_prefix = file[:-7] if (".nii.gz" in file) else file[:-4] mask_name = "{0:}/{1:}.nii.gz".format(args.dir_mask, file_prefix) if(not os.path.isfile(mask_name)): mask_name = "{0:}/{1:}.nii".format(args.dir_mask, file_prefix) assert(os.path.isfile(mask_name)) mask_files.append(mask_name) if args.target_stack is None: target_stack = input_files[0] else: target_stack = input_files if args.run_recon_subject_space: target_stack_index = input_files.index(target_stack) cmd_args = [] cmd_args.append("--filenames %s" % (" ").join(input_files)) cmd_args.append("--filenames-masks %s" % (" ").join(mask_files)) cmd_args.append("--multiresolution %d" % args.multiresolution) cmd_args.append("--target-stack-index %d" % target_stack_index) cmd_args.append("--dir-output %s" % dir_output_recon_subject_space) # cmd_args.append("--suffix-mask %s" % args.suffix_mask) cmd_args.append("--intensity-correction %d" % args.intensity_correction) cmd_args.append("--alpha %s" % args.alpha) cmd_args.append("--iter-max %d" % args.iter_max) cmd_args.append("--two-step-cycles %d" % args.two_step_cycles) cmd_args.append("--outlier-rejection %d" % args.outlier_rejection) cmd_args.append("--use-robust-registration %d" % args.use_robust_registration) cmd_args.append("--verbose %d" % args.verbose) if args.isotropic_resolution is not None: cmd_args.append("--isotropic-resolution %f" % args.isotropic_resolution) if args.reference is not None: cmd_args.append("--reference %s" % args.reference) if args.reference_mask is not None: cmd_args.append("--reference-mask %s" % args.reference_mask) cmd = "niftymic_reconstruct_volume %s" % (" ").join(cmd_args) time_start_volrec = ph.start_timing() exit_code = ph.execute_command(cmd) if exit_code != 0: raise RuntimeError("Reconstruction in subject space failed") elapsed_time_volrec = ph.stop_timing(time_start_volrec) else: elapsed_time_volrec = ph.get_zero_time() if args.run_recon_template_space: # register recon to template space pattern = "[a-zA-Z0-9_]+(stacks)[a-zA-Z0-9_]+(.nii.gz)" p = re.compile(pattern) reconstruction = [ os.path.join( dir_output_recon_subject_space, p.match(f).group(0)) for f in os.listdir(dir_output_recon_subject_space) if p.match(f)][0] if('mask_manual' in args.dir_output): # find the corresponding template by volume matching reconstruction_mask = reconstruction if(not ("_mask" in reconstruction)): reconstruction_mask = ph.append_to_filename(reconstruction, "_mask") template_stack_estimator = \ tse.TemplateStackEstimator.from_mask( reconstruction_mask, args.dir_input_templates) template_mask = template_stack_estimator.get_path_to_template() template = template_mask.replace('_mask_dil.nii.gz', '.nii.gz') print('template name', template) # template = os.path.join( # args.dir_input_templates, # "STA%d.nii.gz" % args.gestational_age) # template_mask = os.path.join( # args.dir_input_templates, # "STA%d_mask.nii.gz" % args.gestational_age) else: template_folder = args.dir_output + "/../../mask_manual/reconstruct_outlier_gpr/" file_names = os.listdir(template_folder) template_names = [item for item in file_names if ("nii.gz" in item) and ("Masked" not in item)] mask_names = [item for item in file_names if ("nii.gz" in item) and ("Masked" in item)] template = os.path.join(template_folder, template_names[0]) template_mask = os.path.join(template_folder, mask_names[0]) cmd_args = [] cmd_args.append("--moving %s" % reconstruction) cmd_args.append("--fixed %s" % template) # if(use_spatiotemporal_template is False): # cmd_args.append("--use-fixed-mask 1") # added by Guotai # cmd_args.append("--template-mask %s" % template_mask) # micheal's code cmd_args.append("--dir-input %s" % os.path.join( dir_output_recon_subject_space, "motion_correction")) cmd_args.append("--dir-output %s" % dir_output_recon_template_space) cmd_args.append("--suffix-mask %s" % args.suffix_mask) cmd_args.append("--verbose %s" % args.verbose) cmd = "niftymic_register_image %s" % (" ").join(cmd_args) exit_code = ph.execute_command(cmd) if exit_code != 0: raise RuntimeError("Registration to template space failed") # reconstruct volume in template space # pattern = "[a-zA-Z0-9_.]+(ResamplingToTemplateSpace.nii.gz)" # p = re.compile(pattern) # reconstruction_space = [ # os.path.join(dir_output_recon_template_space, p.match(f).group(0)) # for f in os.listdir(dir_output_recon_template_space) # if p.match(f)][0] dir_input = os.path.join( dir_output_recon_template_space, "motion_correction") cmd_args = [] cmd_args.append("--dir-input %s" % dir_input) cmd_args.append("--dir-output %s" % dir_output_recon_template_space) cmd_args.append("--reconstruction-space %s" % template) cmd_args.append("--iter-max %d" % args.iter_max) cmd_args.append("--alpha %s" % args.alpha) cmd_args.append("--suffix-mask %s" % args.suffix_mask) cmd = "niftymic_reconstruct_volume_from_slices %s" % \ (" ").join(cmd_args) exit_code = ph.execute_command(cmd) if exit_code != 0: raise RuntimeError("Reconstruction in template space failed") pattern = "[a-zA-Z0-9_.]+(stacks[0-9]+).*(.nii.gz)" p = re.compile(pattern) reconstruction = { p.match(f).group(1): os.path.join( dir_output_recon_template_space, p.match(f).group(0)) for f in os.listdir(dir_output_recon_template_space) if p.match(f) and not p.match(f).group(0).endswith( "ResamplingToTemplateSpace.nii.gz")} key = reconstruction.keys()[0] path_to_recon = reconstruction[key] # Copy SRR to output directory output = "%sSRR_%s_GW%d.nii.gz" % ( args.prefix_output, key, args.gestational_age) path_to_output = os.path.join(args.dir_output, output) cmd = "cp -p %s %s" % (path_to_recon, path_to_output) exit_code = ph.execute_command(cmd) if exit_code != 0: raise RuntimeError("Copy of SRR to output directory failed") # Multiply template mask with reconstruction cmd_args = [] cmd_args.append("--filename %s" % path_to_output) cmd_args.append("--gestational-age %s" % args.gestational_age) cmd_args.append("--verbose %s" % args.verbose) cmd_args.append("--dir-input-templates %s " % args.dir_input_templates) cmd = "niftymic_multiply_stack_with_mask %s" % ( " ").join(cmd_args) exit_code = ph.execute_command(cmd) if exit_code != 0: raise RuntimeError("SRR brain masking failed") else: elapsed_time_template = ph.get_zero_time() if args.run_data_vs_simulated_data: dir_input = os.path.join( dir_output_recon_template_space, "motion_correction") pattern = "[a-zA-Z0-9_.]+(stacks[0-9]+).*(.nii.gz)" # pattern = "Masked_[a-zA-Z0-9_.]+(stacks[0-9]+).*(.nii.gz)" p = re.compile(pattern) reconstruction = { p.match(f).group(1): os.path.join( dir_output_recon_template_space, p.match(f).group(0)) for f in os.listdir(dir_output_recon_template_space) if p.match(f) and not p.match(f).group(0).endswith( "ResamplingToTemplateSpace.nii.gz")} key = reconstruction.keys()[0] path_to_recon = reconstruction[key] # Get simulated/projected slices cmd_args = [] cmd_args.append("--dir-input %s" % dir_input) cmd_args.append("--dir-output %s" % dir_output_data_vs_simulatd_data) cmd_args.append("--reconstruction %s" % path_to_recon) cmd_args.append("--copy-data 1") cmd_args.append("--suffix-mask %s" % args.suffix_mask) # cmd_args.append("--verbose %s" % args.verbose) exe = os.path.abspath(simulate_stacks_from_reconstruction.__file__) cmd = "python %s %s" % (exe, (" ").join(cmd_args)) exit_code = ph.execute_command(cmd) if exit_code != 0: raise RuntimeError("SRR slice projections failed") filenames_simulated = [ os.path.join(dir_output_data_vs_simulatd_data, os.path.basename(f)) for f in input_files] dir_output_evaluation = os.path.join( dir_output_data_vs_simulatd_data, "evaluation") dir_output_figures = os.path.join( dir_output_data_vs_simulatd_data, "figures") dir_output_side_by_side = os.path.join( dir_output_figures, "side-by-side") # Evaluate slice similarities to ground truth cmd_args = [] cmd_args.append("--filenames %s" % (" ").join(filenames_simulated)) cmd_args.append("--suffix-mask %s" % args.suffix_mask) cmd_args.append("--measures NCC SSIM") cmd_args.append("--dir-output %s" % dir_output_evaluation) exe = os.path.abspath(evaluate_simulated_stack_similarity.__file__) cmd = "python %s %s" % (exe, (" ").join(cmd_args)) exit_code = ph.execute_command(cmd) if exit_code != 0: raise RuntimeError("Evaluation of slice similarities failed") # Generate figures showing the quantitative comparison cmd_args = [] cmd_args.append("--dir-input %s" % dir_output_evaluation) cmd_args.append("--dir-output %s" % dir_output_figures) exe = os.path.abspath( show_evaluated_simulated_stack_similarity.__file__) cmd = "python %s %s" % (exe, (" ").join(cmd_args)) exit_code = ph.execute_command(cmd) if exit_code != 0: ph.print_warning("Visualization of slice similarities failed") # Generate pdfs showing all the side-by-side comparisons cmd_args = [] cmd_args.append("--filenames %s" % (" ").join(filenames_simulated)) cmd_args.append("--dir-output %s" % dir_output_side_by_side) exe = os.path.abspath( export_side_by_side_simulated_vs_original_slice_comparison.__file__) cmd = "python %s %s" % (exe, (" ").join(cmd_args)) exit_code = ph.execute_command(cmd) if exit_code != 0: raise RuntimeError("Generation of PDF overview failed") ph.print_title("Summary") print("Computational Time for Volumetric Reconstruction: %s" % elapsed_time_volrec) print("Computational Time for Pipeline: %s" % ph.stop_timing(time_start)) return 0