Пример #1
0
    def commit(self):
        if self.currentGds:
            self.error(0)
            sample_type = None
            self.progressBarInit(processEvents=None)

            _, groups = self.selectedSamples()
            if len(groups) == 1 and self.outputRows:
                sample_type = groups[0]

            self.setEnabled(False)
            self.setBlocking(True)

            progress = methodinvoke(self, "progressCompleted", (int, int))

            def get_data(gds_id, report_genes, transpose, sample_type, title):
                gds_ensure_downloaded(gds_id, progress)
                gds = geo.GDS(gds_id)
                data = gds.getdata(report_genes=report_genes,
                                   transpose=transpose,
                                   sample_type=sample_type)
                data.name = title
                return data

            get_data = partial(get_data,
                               self.currentGds["dataset_id"],
                               report_genes=self.mergeSpots,
                               transpose=self.outputRows,
                               sample_type=sample_type,
                               title=self.datasetName
                               or self.currentGds["title"])
            self._datatask = Task(function=get_data)
            self._datatask.finished.connect(self._on_dataready)
            self._executor.submit(self._datatask)
Пример #2
0
 def fetch_network():
     geneinfo = geneinfo_f.result()
     ppidb = fetch_ppidb(source, db_taxid, progress)
     return get_gene_network(ppidb, geneinfo, db_taxid, query_genes,
                             include_neighborhood=include_neighborhood,
                             min_score=min_score,
                             progress=methodinvoke(self, "set_progress", (float,)))
Пример #3
0
    def commit(self):
        if self.currentGds:
            self.error(0)
            sample_type = None
            self.progressBarInit(processEvents=None)

            _, groups = self.selectedSamples()
            if len(groups) == 1 and self.outputRows:
                sample_type = groups[0]

            self.setEnabled(False)
            self.setBlocking(True)

            progress = methodinvoke(self, "progressCompleted", (int, int))

            def get_data(gds_id, report_genes, transpose, sample_type, title):
                gds_ensure_downloaded(gds_id, progress)
                gds = geo.GDS(gds_id)
                data = gds.getdata(
                    report_genes=report_genes, transpose=transpose,
                    sample_type=sample_type
                )
                data.name = title
                return data

            get_data = partial(
                get_data, self.currentGds["dataset_id"],
                report_genes=self.mergeSpots,
                transpose=self.outputRows,
                sample_type=sample_type,
                title=self.datasetName or self.currentGds["title"]
            )
            self._datatask = Task(function=get_data)
            self._datatask.finished.connect(self._on_dataready)
            self._executor.submit(self._datatask)
    def RetrieveFilesList(self):
        self.progress.setRange(0, 3)
        self.serverFiles = serverfiles.ServerFiles()

        task = Task(function=partial(retrieveFilesList, methodinvoke(self.progress, "advance")))

        task.resultReady.connect(self.SetFilesList)
        task.exceptionReady.connect(self.HandleError)

        self.executor.submit(task)

        self.setEnabled(False)
Пример #5
0
    def RetrieveFilesList(self):
        self.retryButton.hide()
        self.warning(0)
        self.progress.setRange(0, 3)

        task = Task(function=partial(retrieveFilesList, methodinvoke(self.progress, "advance")))

        task.resultReady.connect(self.SetFilesList)
        task.exceptionReady.connect(self.HandleError)

        self.executor.submit(task)

        self.setEnabled(False)
Пример #6
0
    def RetrieveFilesList(self):
        self.retryButton.hide()
        self.warning(0)
        self.progress.setRange(0, 3)
        self.serverFiles = serverfiles.ServerFiles(access_code=self.accessCode)

        task = Task(function=partial(retrieveFilesList, self.serverFiles,
                                     self.domains,
                                     methodinvoke(self.progress, "advance")))

        task.resultReady.connect(self.SetFilesList)
        task.exceptionReady.connect(self.HandleError)

        self.executor.submit(task)

        self.setEnabled(False)
Пример #7
0
    def commit(self):
        include_neighborhood = self.include_neighborhood
        query_genes = self.query_genes()
        source = SOURCES[self.network_source]
        if source.score_filter:
            min_score = self.min_score
            assert source.name == "STRING"
            min_score = min_score * 1000
        else:
            min_score = None

        taxid = self.taxid
        progress = methodinvoke(self, "advance")
        if self.geneinfo is None:
            self.geneinfo = self.executor.submit(fetch_ncbi_geneinfo, taxid,
                                                 progress)

        geneinfo_f = self.geneinfo
        taxmap = source.tax_mapping
        db_taxid = taxmap.get(taxid, taxid)

        if db_taxid is None:
            raise ValueError("invalid taxid for this network")

        def fetch_network():
            geneinfo = geneinfo_f.result()
            ppidb = fetch_ppidb(source, db_taxid, progress)
            return get_gene_network(ppidb,
                                    geneinfo,
                                    db_taxid,
                                    query_genes,
                                    include_neighborhood=include_neighborhood,
                                    min_score=min_score,
                                    progress=methodinvoke(
                                        self, "set_progress", (float, )))

        self.nettask = Task(function=fetch_network)
        self.nettask.finished.connect(self._on_result_ready)

        self.executor.submit(self.nettask)

        self.setBlocking(True)
        self.setEnabled(False)
        self.progressBarInit()
        self._invalidated = False
        self._update_info()
Пример #8
0
    def _initialize(self):
        # First try to import slumber to see if we can even use the
        # kegg module.
        try:
            import slumber
        except ImportError:
            QMessageBox.warning(self,
                "'slumber' library required.",
                '<p>Please install '
                '<a href="http://pypi.python.org/pypi/slumber">slumber</a> '
                'library to use KEGG Pathways widget.</p>'
            )
            self.infoLabel.setText(
                '<p>Please install '
                '<a href="http://pypi.python.org/pypi/slumber">slumber</a> '
                'library to use KEGG Pathways widget.</p>'
            )
            self.error(0, "Missing slumber/requests library")
            return

        progress = methodinvoke(self, "setProgress", (float,))

        def get_genome():
            """Return a KEGGGenome with the common org entries precached."""
            genome = kegg.KEGGGenome()

            essential = genome.essential_organisms()
            common = genome.common_organisms()
            # Remove duplicates of essential from common.
            # (essential + common list as defined here will be used in the
            # GUI.)
            common = [c for c in common if c not in essential]

            # TODO: Add option to specify additional organisms not
            # in the common list.

            keys = map(genome.org_code_to_entry_key, essential + common)

            genome.pre_cache(keys, progress_callback=progress)
            return (keys, genome)

        self._genomeTask = task = Task(function=get_genome)
        task.finished.connect(self._initializeOrganisms)

        self.progressBarInit()
        self._executor.submit(task)
Пример #9
0
    def commit(self):
        include_neighborhood = self.include_neighborhood
        query_genes = self.query_genes()
        source = SOURCES[self.network_source]
        if source.score_filter:
            min_score = self.min_score
            assert source.name == "STRING"
            min_score = min_score * 1000
        else:
            min_score = None

        taxid = self.taxid
        progress = methodinvoke(self, "advance")
        if self.geneinfo is None:
            self.geneinfo = self.executor.submit(
                fetch_ncbi_geneinfo, taxid, progress
            )

        geneinfo_f = self.geneinfo
        taxmap = source.tax_mapping
        db_taxid = taxmap.get(taxid, taxid)

        if db_taxid is None:
            raise ValueError("invalid taxid for this network")

        def fetch_network():
            geneinfo = geneinfo_f.result()
            ppidb = fetch_ppidb(source, db_taxid, progress)
            return get_gene_network(ppidb, geneinfo, db_taxid, query_genes,
                                    include_neighborhood=include_neighborhood,
                                    min_score=min_score,
                                    progress=methodinvoke(self, "set_progress", (float,)))

        self.nettask = Task(function=fetch_network)
        self.nettask.finished.connect(self._on_result_ready)

        self.executor.submit(self.nettask)

        self.setBlocking(True)
        self.setEnabled(False)
        self.progressBarInit()
        self._invalidated = False
        self._update_info()
Пример #10
0
    def updateInfoItems(self):
        self.warning(0)
        if not self.data:
            return

        genes = self.inputGenes()
        if self.useAttr:
            genes = [attr.name for attr in self.data.domain.attributes]
        elif self.attributes:
            attr = self.attributes[self.geneAttr]
            genes = [str(ex[attr]) for ex in self.data
                     if not ex[attr].isSpecial()]
        else:
            genes = []
        if not genes:
            self.warning(0, "Could not extract genes from input dataset.")

        self.warning(1)
        org = self.organisms[min(self.organismIndex, len(self.organisms) - 1)]
        source_name, info_getter = self.infoSource()

        self.error(0)

        self.updateDictyExpressLink(genes, show=org == "352472")
        self.altSourceCheck.setVisible(org == "352472")

        self.progressBarInit()
        self.setBlocking(True)
        self.setEnabled(False)
        self.infoLabel.setText("Retrieving info records.\n")

        self.genes = genes

        task = Task(
            function=partial(
                info_getter, org, genes,
                advance=methodinvoke(self, "advance", ()))
        )
        self.itemsfuture = self.executor.submit(task)
        task.finished.connect(self._onItemsCompleted)
Пример #11
0
    def __init__(self, parent=None, signalManager=None, name=" GEO Data Sets"):
        OWWidget.__init__(self, parent, signalManager, name)

        self.selectionChanged = False
        self.filterString = ""
        self.datasetName = ""

        ## GUI
        box = gui.widgetBox(self.controlArea, "Info", addSpace=True)
        self.infoBox = gui.widgetLabel(box, "Initializing\n\n")

        box = gui.widgetBox(self.controlArea, "Output", addSpace=True)
        gui.radioButtonsInBox(box,
                              self,
                              "outputRows",
                              ["Genes in rows", "Samples in rows"],
                              "Rows",
                              callback=self.commitIf)

        gui.checkBox(box,
                     self,
                     "mergeSpots",
                     "Merge spots of same gene",
                     callback=self.commitIf)

        gui.separator(box)
        self.nameEdit = gui.lineEdit(
            box,
            self,
            "datasetName",
            "Data set name",
            tooltip="Override the default output data set name",
            callback=self.onNameEdited)
        self.nameEdit.setPlaceholderText("")

        if sys.version_info < (3, ):
            box = gui.widgetBox(self.controlArea, "Commit", addSpace=True)
            self.commitButton = gui.button(box,
                                           self,
                                           "Commit",
                                           callback=self.commit)
            cb = gui.checkBox(box, self, "autoCommit", "Commit on any change")
            gui.setStopper(self, self.commitButton, cb, "selectionChanged",
                           self.commit)
        else:
            gui.auto_commit(self.controlArea,
                            self,
                            "autoCommit",
                            "Commit",
                            box="Commit")
            self.commitIf = self.commit

        gui.rubber(self.controlArea)

        gui.widgetLabel(self.mainArea, "Filter")
        self.filterLineEdit = QLineEdit(textChanged=self.filter)
        self.completer = TokenListCompleter(self,
                                            caseSensitivity=Qt.CaseInsensitive)
        self.filterLineEdit.setCompleter(self.completer)

        self.mainArea.layout().addWidget(self.filterLineEdit)

        splitter = QSplitter(Qt.Vertical, self.mainArea)
        self.mainArea.layout().addWidget(splitter)
        self.treeWidget = QTreeView(splitter)

        self.treeWidget.setSelectionMode(QTreeView.SingleSelection)
        self.treeWidget.setRootIsDecorated(False)
        self.treeWidget.setSortingEnabled(True)
        self.treeWidget.setAlternatingRowColors(True)
        self.treeWidget.setUniformRowHeights(True)
        self.treeWidget.setEditTriggers(QTreeView.NoEditTriggers)

        linkdelegate = LinkStyledItemDelegate(self.treeWidget)
        self.treeWidget.setItemDelegateForColumn(1, linkdelegate)
        self.treeWidget.setItemDelegateForColumn(8, linkdelegate)
        self.treeWidget.setItemDelegateForColumn(
            0, gui.IndicatorItemDelegate(self.treeWidget, role=Qt.DisplayRole))

        proxyModel = MySortFilterProxyModel(self.treeWidget)
        self.treeWidget.setModel(proxyModel)
        self.treeWidget.selectionModel().selectionChanged.connect(
            self.updateSelection)
        self.treeWidget.viewport().setMouseTracking(True)

        splitterH = QSplitter(Qt.Horizontal, splitter)

        box = gui.widgetBox(splitterH, "Description")
        self.infoGDS = gui.widgetLabel(box, "")
        self.infoGDS.setWordWrap(True)
        gui.rubber(box)

        box = gui.widgetBox(splitterH, "Sample Annotations")
        self.annotationsTree = QTreeWidget(box)
        self.annotationsTree.setHeaderLabels(
            ["Type (Sample annotations)", "Sample count"])
        self.annotationsTree.setRootIsDecorated(True)
        box.layout().addWidget(self.annotationsTree)
        self.annotationsTree.itemChanged.connect(
            self.annotationSelectionChanged)
        self._annotationsUpdating = False
        self.splitters = splitter, splitterH

        for sp, setting in zip(self.splitters, self.splitterSettings):
            sp.splitterMoved.connect(self.splitterMoved)
            sp.restoreState(setting)

        self.searchKeys = [
            "dataset_id", "title", "platform_organism", "description"
        ]

        self.gds = []
        self.gds_info = None

        self.resize(1000, 600)

        self.setBlocking(True)
        self.setEnabled(False)
        self.progressBarInit()

        self._executor = ThreadExecutor()

        func = partial(get_gds_model,
                       methodinvoke(self, "_setProgress", (float, )))
        self._inittask = Task(function=func)
        self._inittask.finished.connect(self._initializemodel)
        self._executor.submit(self._inittask)

        self._datatask = None
Пример #12
0
    def __init__(self, parent=None, signalManager=None, name=" GEO Data Sets"):
        OWWidget.__init__(self, parent, signalManager, name)

        self.outputs = [("Expression Data", ExampleTable)]

        ## Settings
        self.selectedAnnotation = 0
        self.includeIf = False
        self.minSamples = 3
        self.autoCommit = False
        self.outputRows = 0
        self.mergeSpots = True
        self.filterString = ""
        self.currentGds = None
        self.selectionChanged = False
        self.autoCommit = False
        self.gdsSelectionStates = {}
        self.splitterSettings = [
            '\x00\x00\x00\xff\x00\x00\x00\x00\x00\x00\x00\x02\x00\x00\x01\xea\x00\x00\x00\xd7\x01\x00\x00\x00\x07\x01\x00\x00\x00\x02',
            '\x00\x00\x00\xff\x00\x00\x00\x00\x00\x00\x00\x02\x00\x00\x01\xb5\x00\x00\x02\x10\x01\x00\x00\x00\x07\x01\x00\x00\x00\x01'
        ]
        self.datasetNames = {}
        self.loadSettings()

        self.datasetName = ""

        ## GUI
        self.infoBox = OWGUI.widgetLabel(
            OWGUI.widgetBox(self.controlArea, "Info", addSpace=True),
            "Initializing\n\n"
        )

        box = OWGUI.widgetBox(self.controlArea, "Output", addSpace=True)
        OWGUI.radioButtonsInBox(box, self, "outputRows",
                                ["Genes or spots", "Samples"], "Rows",
                                callback=self.commitIf)
        OWGUI.checkBox(box, self, "mergeSpots", "Merge spots of same gene",
                       callback=self.commitIf)

        OWGUI.separator(box)
        self.nameEdit = OWGUI.lineEdit(
            box, self, "datasetName", "Data set name",
            tooltip="Override the default output data set name",
            callback=self.onNameEdited
        )
        self.nameEdit.setPlaceholderText("")

        box = OWGUI.widgetBox(self.controlArea, "Commit", addSpace=True)
        self.commitButton = OWGUI.button(box, self, "Commit",
                                         callback=self.commit)
        cb = OWGUI.checkBox(box, self, "autoCommit", "Commit on any change")
        OWGUI.setStopper(self, self.commitButton, cb, "selectionChanged",
                         self.commit)
        OWGUI.rubber(self.controlArea)

        self.filterLineEdit = OWGUIEx.lineEditHint(
            self.mainArea, self, "filterString", "Filter",
            caseSensitive=False, matchAnywhere=True,
            callback=self.filter,  delimiters=" ")

        splitter = QSplitter(Qt.Vertical, self.mainArea)
        self.mainArea.layout().addWidget(splitter)
        self.treeWidget = QTreeView(splitter)

        self.treeWidget.setSelectionMode(QAbstractItemView.SingleSelection)
        self.treeWidget.setRootIsDecorated(False)
        self.treeWidget.setSortingEnabled(True)
        self.treeWidget.setAlternatingRowColors(True)
        self.treeWidget.setUniformRowHeights(True)
        self.treeWidget.setEditTriggers(QTreeView.NoEditTriggers)

        linkdelegate = LinkStyledItemDelegate(self.treeWidget)
        self.treeWidget.setItemDelegateForColumn(1, linkdelegate)
        self.treeWidget.setItemDelegateForColumn(8, linkdelegate)
        self.treeWidget.setItemDelegateForColumn(
            0, OWGUI.IndicatorItemDelegate(self.treeWidget,
                                           role=Qt.DisplayRole))

        proxyModel = MySortFilterProxyModel(self.treeWidget)
        self.treeWidget.setModel(proxyModel)
        self.treeWidget.selectionModel().selectionChanged.connect(
            self.updateSelection
        )
        self.treeWidget.viewport().setMouseTracking(True)

        splitterH = QSplitter(Qt.Horizontal, splitter)

        box = OWGUI.widgetBox(splitterH, "Description")
        self.infoGDS = OWGUI.widgetLabel(box, "")
        self.infoGDS.setWordWrap(True)
        OWGUI.rubber(box)

        box = OWGUI.widgetBox(splitterH, "Sample Annotations")
        self.annotationsTree = QTreeWidget(box)
        self.annotationsTree.setHeaderLabels(
            ["Type (Sample annotations)", "Sample count"]
        )
        self.annotationsTree.setRootIsDecorated(True)
        box.layout().addWidget(self.annotationsTree)
        self.annotationsTree.itemChanged.connect(
            self.annotationSelectionChanged
        )
        self._annotationsUpdating = False
        self.splitters = splitter, splitterH

        for sp, setting in zip(self.splitters, self.splitterSettings):
            sp.splitterMoved.connect(self.splitterMoved)
            sp.restoreState(setting)

        self.searchKeys = ["dataset_id", "title", "platform_organism",
                           "description"]

        self.gds = []
        self.gds_info = None

        self.resize(1000, 600)

        self.setBlocking(True)
        self.setEnabled(False)
        self.progressBarInit()

        self._executor = ThreadExecutor()

        func = partial(get_gds_model,
                       methodinvoke(self, "_setProgress", (float,)))
        self._inittask = Task(function=func)
        self._inittask.finished.connect(self._initializemodel)
        self._executor.submit(self._inittask)

        self._datatask = None
Пример #13
0
    def __init__(self, parent=None, signalManager=None, name=" GEO Data Sets"):
        OWWidget.__init__(self, parent, signalManager, name)

        self.selectionChanged = False
        self.filterString = ""
        self.datasetName = ""

        ## GUI
        box = gui.widgetBox(self.controlArea, "Info", addSpace=True)
        self.infoBox = gui.widgetLabel(box, "Initializing\n\n")

        box = gui.widgetBox(self.controlArea, "Output", addSpace=True)
        gui.radioButtonsInBox(box, self, "outputRows",
                              ["Genes in rows", "Samples in rows"], "Rows",
                              callback=self.commitIf)

        gui.checkBox(box, self, "mergeSpots", "Merge spots of same gene",
                     callback=self.commitIf)

        gui.separator(box)
        self.nameEdit = gui.lineEdit(
            box, self, "datasetName", "Data set name",
            tooltip="Override the default output data set name",
            callback=self.onNameEdited
        )
        self.nameEdit.setPlaceholderText("")

        if sys.version_info < (3, ):
            box = gui.widgetBox(self.controlArea, "Commit", addSpace=True)
            self.commitButton = gui.button(
                box, self, "Commit", callback=self.commit)
            cb = gui.checkBox(box, self, "autoCommit", "Commit on any change")
            gui.setStopper(self, self.commitButton, cb, "selectionChanged",
                           self.commit)
        else:
            gui.auto_commit(self.controlArea, self, "autoCommit", "Commit",
                            box="Commit")
            self.commitIf = self.commit

        gui.rubber(self.controlArea)

        gui.widgetLabel(self.mainArea, "Filter")
        self.filterLineEdit = QLineEdit(
            textChanged=self.filter
        )
        self.completer = TokenListCompleter(
            self, caseSensitivity=Qt.CaseInsensitive
        )
        self.filterLineEdit.setCompleter(self.completer)

        self.mainArea.layout().addWidget(self.filterLineEdit)

        splitter = QSplitter(Qt.Vertical, self.mainArea)
        self.mainArea.layout().addWidget(splitter)
        self.treeWidget = QTreeView(splitter)

        self.treeWidget.setSelectionMode(QTreeView.SingleSelection)
        self.treeWidget.setRootIsDecorated(False)
        self.treeWidget.setSortingEnabled(True)
        self.treeWidget.setAlternatingRowColors(True)
        self.treeWidget.setUniformRowHeights(True)
        self.treeWidget.setEditTriggers(QTreeView.NoEditTriggers)

        linkdelegate = LinkStyledItemDelegate(self.treeWidget)
        self.treeWidget.setItemDelegateForColumn(1, linkdelegate)
        self.treeWidget.setItemDelegateForColumn(8, linkdelegate)
        self.treeWidget.setItemDelegateForColumn(
            0, gui.IndicatorItemDelegate(self.treeWidget,
                                         role=Qt.DisplayRole))

        proxyModel = MySortFilterProxyModel(self.treeWidget)
        self.treeWidget.setModel(proxyModel)
        self.treeWidget.selectionModel().selectionChanged.connect(
            self.updateSelection
        )
        self.treeWidget.viewport().setMouseTracking(True)

        splitterH = QSplitter(Qt.Horizontal, splitter)

        box = gui.widgetBox(splitterH, "Description")
        self.infoGDS = gui.widgetLabel(box, "")
        self.infoGDS.setWordWrap(True)
        gui.rubber(box)

        box = gui.widgetBox(splitterH, "Sample Annotations")
        self.annotationsTree = QTreeWidget(box)
        self.annotationsTree.setHeaderLabels(
            ["Type (Sample annotations)", "Sample count"]
        )
        self.annotationsTree.setRootIsDecorated(True)
        box.layout().addWidget(self.annotationsTree)
        self.annotationsTree.itemChanged.connect(
            self.annotationSelectionChanged
        )
        self._annotationsUpdating = False
        self.splitters = splitter, splitterH

        for sp, setting in zip(self.splitters, self.splitterSettings):
            sp.splitterMoved.connect(self.splitterMoved)
            sp.restoreState(setting)

        self.searchKeys = ["dataset_id", "title", "platform_organism",
                           "description"]

        self.gds = []
        self.gds_info = None

        self.resize(1000, 600)

        self.setBlocking(True)
        self.setEnabled(False)
        self.progressBarInit()

        self._executor = ThreadExecutor()

        func = partial(get_gds_model,
                       methodinvoke(self, "_setProgress", (float,)))
        self._inittask = Task(function=func)
        self._inittask.finished.connect(self._initializemodel)
        self._executor.submit(self._inittask)

        self._datatask = None
Пример #14
0
    def __init__(self, parent=None, signalManager=None, name=" GEO Data Sets"):
        OWWidget.__init__(self, parent, signalManager, name)

        self.outputs = [("Expression Data", ExampleTable)]

        ## Settings
        self.selectedAnnotation = 0
        self.includeIf = False
        self.minSamples = 3
        self.autoCommit = False
        self.outputRows = 1
        self.mergeSpots = True
        self.filterString = ""
        self.currentGds = None
        self.selectionChanged = False
        self.autoCommit = False
        self.gdsSelectionStates = {}
        self.splitterSettings = [
            '\x00\x00\x00\xff\x00\x00\x00\x00\x00\x00\x00\x02\x00\x00\x01\xea\x00\x00\x00\xd7\x01\x00\x00\x00\x07\x01\x00\x00\x00\x02',
            '\x00\x00\x00\xff\x00\x00\x00\x00\x00\x00\x00\x02\x00\x00\x01\xb5\x00\x00\x02\x10\x01\x00\x00\x00\x07\x01\x00\x00\x00\x01'
        ]
        self.datasetNames = {}
        self.loadSettings()

        self.datasetName = ""

        ## GUI
        self.infoBox = OWGUI.widgetLabel(
            OWGUI.widgetBox(self.controlArea, "Info", addSpace=True),
            "Initializing\n\n"
        )

        box = OWGUI.widgetBox(self.controlArea, "Output", addSpace=True)
        OWGUI.radioButtonsInBox(box, self, "outputRows",
                                ["Genes in rows", "Samples in rows"], "Rows",
                                callback=self.commitIf)
        OWGUI.checkBox(box, self, "mergeSpots", "Merge spots of same gene",
                       callback=self.commitIf)

        OWGUI.separator(box)
        self.nameEdit = OWGUI.lineEdit(
            box, self, "datasetName", "Data set name",
            tooltip="Override the default output data set name",
            callback=self.onNameEdited
        )
        self.nameEdit.setPlaceholderText("")

        box = OWGUI.widgetBox(self.controlArea, "Commit", addSpace=True)
        self.commitButton = OWGUI.button(box, self, "Commit",
                                         callback=self.commit)
        cb = OWGUI.checkBox(box, self, "autoCommit", "Commit on any change")
        OWGUI.setStopper(self, self.commitButton, cb, "selectionChanged",
                         self.commit)
        OWGUI.rubber(self.controlArea)

        self.filterLineEdit = OWGUIEx.lineEditHint(
            self.mainArea, self, "filterString", "Filter",
            caseSensitive=False, matchAnywhere=True,
            callback=self.filter,  delimiters=" ")

        splitter = QSplitter(Qt.Vertical, self.mainArea)
        self.mainArea.layout().addWidget(splitter)
        self.treeWidget = QTreeView(splitter)

        self.treeWidget.setSelectionMode(QAbstractItemView.SingleSelection)
        self.treeWidget.setRootIsDecorated(False)
        self.treeWidget.setSortingEnabled(True)
        self.treeWidget.setAlternatingRowColors(True)
        self.treeWidget.setUniformRowHeights(True)
        self.treeWidget.setEditTriggers(QTreeView.NoEditTriggers)

        linkdelegate = LinkStyledItemDelegate(self.treeWidget)
        self.treeWidget.setItemDelegateForColumn(1, linkdelegate)
        self.treeWidget.setItemDelegateForColumn(8, linkdelegate)
        self.treeWidget.setItemDelegateForColumn(
            0, OWGUI.IndicatorItemDelegate(self.treeWidget,
                                           role=Qt.DisplayRole))

        proxyModel = MySortFilterProxyModel(self.treeWidget)
        self.treeWidget.setModel(proxyModel)
        self.treeWidget.selectionModel().selectionChanged.connect(
            self.updateSelection
        )
        self.treeWidget.viewport().setMouseTracking(True)

        splitterH = QSplitter(Qt.Horizontal, splitter)

        box = OWGUI.widgetBox(splitterH, "Description")
        self.infoGDS = OWGUI.widgetLabel(box, "")
        self.infoGDS.setWordWrap(True)
        OWGUI.rubber(box)

        box = OWGUI.widgetBox(splitterH, "Sample Annotations")
        self.annotationsTree = QTreeWidget(box)
        self.annotationsTree.setHeaderLabels(
            ["Type (Sample annotations)", "Sample count"]
        )
        self.annotationsTree.setRootIsDecorated(True)
        box.layout().addWidget(self.annotationsTree)
        self.annotationsTree.itemChanged.connect(
            self.annotationSelectionChanged
        )
        self._annotationsUpdating = False
        self.splitters = splitter, splitterH

        for sp, setting in zip(self.splitters, self.splitterSettings):
            sp.splitterMoved.connect(self.splitterMoved)
            sp.restoreState(setting)

        self.searchKeys = ["dataset_id", "title", "platform_organism",
                           "description"]

        self.gds = []
        self.gds_info = None

        self.resize(1000, 600)

        self.setBlocking(True)
        self.setEnabled(False)
        self.progressBarInit()

        self._executor = ThreadExecutor()

        func = partial(get_gds_model,
                       methodinvoke(self, "_setProgress", (float,)))
        self._inittask = Task(function=func)
        self._inittask.finished.connect(self._initializemodel)
        self._executor.submit(self._inittask)

        self._datatask = None
Пример #15
0
    def __init__(self, parent=None, signalManager=None, name="Gene Info"):
        OWWidget.__init__(self, parent, signalManager, name)

        self.inputs = [("Examples", Orange.data.Table, self.setData)]
        self.outputs = [("Selected Examples", Orange.data.Table)]

        self.organismIndex = 0
        self.taxid = None
        self.geneAttr = 0
        self.useAttr = False
        self.autoCommit = False
        self.searchString = ""
        self.selectionChangedFlag = False
        self.useAltSource = 0
        self.loadSettings()

        self.__initialized = False
        self.initfuture = None
        self.itemsfuture = None

        self.infoLabel = OWGUI.widgetLabel(
            OWGUI.widgetBox(self.controlArea, "Info", addSpace=True),
            "Initializing\n"
        )

        self.organisms = None
        self.organismBox = OWGUI.widgetBox(
            self.controlArea, "Organism", addSpace=True)

        self.organismComboBox = OWGUI.comboBox(
            self.organismBox, self, "organismIndex",
            callback=self._onSelectedOrganismChanged,
            debuggingEnabled=0)

        # For now only support one alt source, with a checkbox
        # In the future this can be extended to multiple selections
        self.altSourceCheck = OWGUI.checkBox(self.organismBox, self,
                            "useAltSource", "Show information from dictyBase",
                            callback=self.onAltSourceChange,
#                            debuggingEnabled=0,
                            )
        self.altSourceCheck.hide()

        box = OWGUI.widgetBox(self.controlArea, "Gene names", addSpace=True)
        self.geneAttrComboBox = OWGUI.comboBox(
            box, self, "geneAttr",
            "Gene atttibute", callback=self.updateInfoItems
        )
        OWGUI.checkBox(box, self, "useAttr", "Use attribute names",
                       callback=self.updateInfoItems,
                       disables=[(-1, self.geneAttrComboBox)])

        self.geneAttrComboBox.setDisabled(bool(self.useAttr))

        box = OWGUI.widgetBox(self.controlArea, "Commit", addSpace=True)
        b = OWGUI.button(box, self, "Commit", callback=self.commit)
        c = OWGUI.checkBox(box, self, "autoCommit", "Commit on change")
        OWGUI.setStopper(self, b, c, "selectionChangedFlag",
                         callback=self.commit)

        # A label for dictyExpress link
        self.dictyExpressBox = OWGUI.widgetBox(
            self.controlArea, "Dicty Express")
        self.linkLabel = OWGUI.widgetLabel(self.dictyExpressBox, "")
        self.linkLabel.setOpenExternalLinks(False)
        self.connect(self.linkLabel, SIGNAL("linkActivated(QString)"),
                     self.onDictyExpressLink)
        self.dictyExpressBox.hide()

        OWGUI.rubber(self.controlArea)

        OWGUI.lineEdit(self.mainArea, self, "searchString", "Filter",
                       callbackOnType=True, callback=self.searchUpdate)

        self.treeWidget = QTreeView(self.mainArea)
        self.treeWidget.setRootIsDecorated(False)
        self.treeWidget.setSelectionMode(
            QAbstractItemView.ExtendedSelection)
        self.treeWidget.setItemDelegate(
            LinkStyledItemDelegate(self.treeWidget))
        self.treeWidget.setUniformRowHeights(True)
        self.treeWidget.viewport().setMouseTracking(True)
        self.treeWidget.setSortingEnabled(True)
        self.mainArea.layout().addWidget(self.treeWidget)

        box = OWGUI.widgetBox(self.mainArea, "",
                              orientation="horizontal")
        OWGUI.button(box, self, "Select Filtered",
                     callback=self.selectFiltered)
        OWGUI.button(box, self, "Clear Selection",
                     callback=self.treeWidget.clearSelection)

        self.resize(1000, 700)

        self.geneinfo = []
        self.cells = []
        self.row2geneinfo = {}
        self.data = None

        # : (# input genes, # matches genes)
        self.matchedInfo = 0, 0
        self.selectionUpdateInProgress = False

        self.setBlocking(True)
        self.executor = ThreadExecutor(self)

        self.progressBarInit()

        task = Task(
            function=partial(
                taxonomy.ensure_downloaded,
                callback=methodinvoke(self, "advance", ())
            )
        )

        task.resultReady.connect(self.initialize)
        task.exceptionReady.connect(self._onInitializeError)

        self.initfuture = self.executor.submit(task)
Пример #16
0
    def Update(self):
        """
        Update (recompute enriched pathways) the widget state.
        """
        if not self.data:
            return

        self.error(0)
        self.information(0)

        # XXX: Check data in setData, do not even alow this to be executed if
        # data has no genes
        try:
            genes = self.GeneNamesFromData(self.data)
        except ValueError:
            self.error(0, "Cannot extract gene names from input.")
            genes = []

        if not self.useAttrNames and any("," in gene for gene in genes):
            genes = reduce(add, (split_and_strip(gene, ",")
                                 for gene in genes),
                           [])
            self.information(0,
                             "Separators detected in input gene names. "
                             "Assuming multiple genes per instance.")
        self.queryGenes = genes

        self.information(1)
        reference = None
        if self.useReference and self.refData:
            reference = self.GeneNamesFromData(self.refData)
            if not self.useAttrNames \
                    and any("," in gene for gene in reference):
                reference = reduce(add, (split_and_strip(gene, ",")
                                         for gene in reference),
                                   [])
                self.information(1,
                                 "Separators detected in reference gene "
                                 "names. Assuming multiple genes per "
                                 "instance.")

        org_code = self.SelectedOrganismCode()

        def run_enrichment(org_code, genes, reference=None, progress=None):
            org = kegg.KEGGOrganism(org_code)
            if reference is None:
                reference = org.get_genes()

            # Map 'genes' and 'reference' sets to unique KEGG identifiers
            unique_genes, _, _ = org.get_unique_gene_ids(set(genes))
            unique_ref_genes, _, _ = org.get_unique_gene_ids(set(reference))

            taxid = kegg.to_taxid(org.org_code)
            # Map the taxid back to standard 'common' taxids
            # (as used by 'geneset') if applicable
            r_tax_map = dict((v, k) for k, v in
                             kegg.KEGGGenome.TAXID_MAP.items())
            if taxid in r_tax_map:
                taxid = r_tax_map[taxid]

            # We use the kegg pathway gene sets provided by 'geneset' for
            # the enrichment calculation.

            # Ensure we are using the latest genesets
            # TODO: ?? Is updating the index enough?
            serverfiles.update(geneset.sfdomain, "index.pck")
            kegg_gs_collections = geneset.collections(
                (("KEGG", "pathways"), taxid)
            )

            pathways = pathway_enrichment(
                kegg_gs_collections, unique_genes.keys(),
                unique_ref_genes.keys(),
                callback=progress
            )
            # Ensure that pathway entries are pre-cached for later use in the
            # list/tree view
            kegg_pathways = kegg.KEGGPathways()
            kegg_pathways.pre_cache(
                pathways.keys(), progress_callback=progress
            )

            return pathways, org, unique_genes, unique_ref_genes

        self.progressBarInit()
        self.setEnabled(False)
        self.infoLabel.setText("Retrieving...\n")

        progress = methodinvoke(self, "setProgress", (float,))
        self._enrichTask = Task(
            function=lambda:
                run_enrichment(org_code, genes, reference, progress)
        )
        self._enrichTask.finished.connect(self._onEnrichTaskFinished)
        self._executor.submit(self._enrichTask)