def validate_nonbinary_trees(self, n):
demographic_events = [
msprime.SimpleBottleneck(0.02, 0, proportion=0.25),
msprime.SimpleBottleneck(0.2, 0, proportion=1)]
for seed in range(1, 10):
ts = msprime.simulate(
n, random_seed=seed, demographic_events=demographic_events)
# Check if this is really nonbinary
found = False
for edgeset in ts.edgesets():
if len(edgeset.children) > 2:
found = True
break
self.assertTrue(found)
tree1 = ts.first()
ts = msprime.simulate(
n, random_seed=seed + 1, demographic_events=demographic_events)
tree2 = ts.first()
self.assertAlmostEqual(
tsinfer.kc_distance(tree1, tree2), kc_distance(tree1, tree2))
self.assertAlmostEqual(
tsinfer.kc_distance(tree2, tree1), kc_distance(tree2, tree1))
# compare to a binary tree also
tree2 = msprime.simulate(n, random_seed=seed + 1).first()
self.assertAlmostEqual(
tsinfer.kc_distance(tree1, tree2), kc_distance(tree1, tree2))
self.assertAlmostEqual(
tsinfer.kc_distance(tree2, tree1), kc_distance(tree2, tree1))
def test_nonbinary_trees(self):
bottlenecks = [
msprime.SimpleBottleneck(0.01, 0, proportion=0.05),
msprime.SimpleBottleneck(0.02, 0, proportion=0.25),
msprime.SimpleBottleneck(0.03, 0, proportion=1)]
ts = msprime.simulate(
10, length=100, recombination_rate=1,
demographic_events=bottlenecks, random_seed=1)
self.verify_tree_sequence(ts)
def test_three_populations_no_migration_recombination(self):
seed = 1234
ts1 = msprime.simulate(
population_configurations=[
msprime.PopulationConfiguration(10),
msprime.PopulationConfiguration(10),
msprime.PopulationConfiguration(10),
],
migration_matrix=np.zeros((3, 3)),
recombination_rate=0.5,
end_time=0.1,
random_seed=seed,
)
ts2 = msprime.simulate(
population_configurations=[
msprime.PopulationConfiguration(),
msprime.PopulationConfiguration(),
msprime.PopulationConfiguration(),
],
migration_matrix=np.zeros((3, 3)),
from_ts=ts1,
recombination_rate=0.5,
demographic_events=[
msprime.SimpleBottleneck(time=0.5,
population=0,
proportion=1.0),
msprime.SimpleBottleneck(time=0.5,
population=1,
proportion=1.0),
msprime.SimpleBottleneck(time=0.5,
population=2,
proportion=1.0),
msprime.MassMigration(0.61, 1, 0, 1.0),
msprime.MassMigration(0.61, 2, 0, 1.0),
msprime.SimpleBottleneck(0.61, population=0, proportion=1.0),
],
random_seed=seed,
)
self.assertGreater(ts2.num_trees, 1)
for tree in ts2.trees():
# We should have three children at the root, and every node below
# should be in one population.
root_children = tree.children(tree.root)
self.assertEqual(len(root_children), 3)
populations = {ts2.node(u).population: u for u in root_children}
self.assertEqual(len(populations), 3)
for pop in [0, 1, 2]:
for node in tree.nodes(populations[pop]):
self.assertEqual(ts2.node(node).population, pop)
def get_bottleneck_examples():
"""
Returns an iterator of example tree sequences with nonbinary
trees.
"""
bottlenecks = [
msprime.SimpleBottleneck(0.01, 0, proportion=0.05),
msprime.SimpleBottleneck(0.02, 0, proportion=0.25),
msprime.SimpleBottleneck(0.03, 0, proportion=1)]
for n in [3, 10, 100]:
ts = msprime.simulate(
n, length=100, recombination_rate=1,
demographic_events=bottlenecks,
random_seed=n)
yield ts
def subset_samples(n, samples):
demographic_events = [msprime.SimpleBottleneck(1000, 0.15)]
demographic_events = []
ts = msprime.simulate(sample_size=n,
Ne=1e4,
length=1e4,
recombination_rate=5e-8,
mutation_rate=2e-8,
random_seed=5,
demographic_events=demographic_events)
# ts = msprime.load(sys.argv[1])
subset = ts.subset(samples)
# print("starting subsetting", len(samples))
# before = time.clock()
# subset = ts.subset(samples)
# duration = time.clock() - before
# print("Subsetting done", duration)
all_trees = ts.trees()
full_tree = next(all_trees)
for subset_tree in subset.trees():
while full_tree.get_interval()[1] <= subset_tree.get_interval()[1]:
# print(full_tree.get_interval(), subset_tree.get_interval())
for u, v in itertools.combinations(range(len(samples)), 2):
# print(u, v, samples[u], samples[v])
t_mrca1 = full_tree.get_tmrca(samples[u], samples[v])
t_mrca2 = subset_tree.get_tmrca(u, v)
assert t_mrca1 == t_mrca2
full_tree = next(all_trees, None)
if full_tree is None:
break
def test_v2_non_binary_records(self):
demographic_events = [
msprime.SimpleBottleneck(time=0.01, population=0, proportion=1)
]
ts = msprime.simulate(sample_size=10,
demographic_events=demographic_events,
random_seed=1)
self.assertRaises(ValueError, tskit.dump_legacy, ts, self.temp_file, 2)
def bottleneck_example():
return msprime.simulate(
random_seed=1,
sample_size=100,
recombination_rate=0.1,
length=10,
demographic_events=[
msprime.SimpleBottleneck(time=0.01, proportion=0.75)])
def test_smc_bottlenecks(self):
# TODO we should have a better exception here.
for model in ["smc", "smc_prime"]:
self.assertRaises(
_msprime.InputError, msprime.simulate, 10, model=model,
demographic_events=[msprime.SimpleBottleneck(1)])
self.assertRaises(
_msprime.InputError, msprime.simulate, 10, model=model,
demographic_events=[msprime.InstantaneousBottleneck(1)])
def get_nonbinary_tree(self):
demographic_events = [
msprime.SimpleBottleneck(time=0.1, population=0, proportion=0.5)]
ts = msprime.simulate(
10, recombination_rate=5, mutation_rate=10,
demographic_events=demographic_events, random_seed=1)
for t in ts.trees():
for u in t.nodes():
if len(t.children(u)) > 2:
return t
assert False
def test_v2_non_binary_records(self):
demographic_events = [
msprime.SimpleBottleneck(time=0.01, proportion=1)
]
ts = msprime.simulate(
sample_size=10,
demographic_events=demographic_events,
random_seed=1)
with tempfile.NamedTemporaryFile() as f:
self.assertRaises(
ValueError, msprime.dump_legacy, ts, f.name)
def test_different_types(self):
events = [
msprime.PopulationParametersChange(time=1, initial_size=1),
msprime.MigrationRateChange(time=1, rate=1),
msprime.MassMigration(time=1, source=1),
msprime.SimpleBottleneck(time=1)
]
for a, b in itertools.combinations(events, 2):
self.assertFalse(models.demographic_events_equal([a], [b], 1))
self.assertFalse(models.demographic_events_equal([b], [a], 1))
self.assertTrue(models.demographic_events_equal([a], [a], 1))
self.assertTrue(models.demographic_events_equal([b], [b], 1))
def get_nonbinary_example(self):
ts = msprime.simulate(
sample_size=20, recombination_rate=10, random_seed=self.random_seed,
demographic_events=[
msprime.SimpleBottleneck(time=0.5, population=0, proportion=1)])
# Make sure this really has some non-binary nodes
found = False
for e in ts.edgesets():
if len(e.children) > 2:
found = True
break
self.assertTrue(found)
return ts
def get_non_binary_tree(n):
demographic_events = [
msprime.SimpleBottleneck(time=0.1, population=0, proportion=0.5)
]
ts = msprime.simulate(n,
demographic_events=demographic_events,
random_seed=3)
tree = ts.first()
found = False
for u in tree.nodes():
if len(tree.children(u)) > 2:
found = True
assert found
return tree
def test_models_demographic_events(self):
Ne = 10000
ts = msprime.simulate(
Ne=Ne,
sample_size=10,
recombination_rate=0.1,
demographic_events=[
msprime.SimulationModelChange(10,
msprime.StandardCoalescent(Ne)),
msprime.SimpleBottleneck(11, population=0, proportion=1.0),
],
random_seed=10,
)
for tree in ts.trees():
self.assertEqual(tree.num_roots, 1)
self.assertEqual(ts.node(tree.root).time, 11)
def f(time=1, population=1, proportion=1):
return msprime.SimpleBottleneck(
time=time, population=population, proportion=proportion)
def test_simple_bottleneck(self):
examples = [
msprime.SimpleBottleneck(time=10, population=2),
msprime.SimpleBottleneck(time=10, population=2, proportion=0.5),
]
self.assert_repr_round_trip(examples)
