def plot_output(cls, ts, i_inj, states, y_states=None, suffix="", show=True, save=False, l=1, lt=1,
targstyle='-'):
"""
Plot voltage and ion concentrations, potentially compared to a target model
Args:
ts(ndarray of dimension [time]): time steps of the measurements
i_inj(ndarray of dimension [time]): input current
states(ndarray of dimension [time, state_var, nb_neuron]):
y_states(list of ndarray [time, nb_neuron], optional): list of values for the target model, each element is an
ndarray containing the recordings of one state variable (Default value = None)
suffix(str): suffix for the name of the saved file (Default value = "")
show(bool): If True, show the figure (Default value = True)
save(bool): If True, save the figure (Default value = False)
l(float): width of the main lines (Default value = 1)
lt(float): width of the target lines (Default value = 1)
targstyle(str): style of the target lines (Default value = '-')
"""
plt.figure()
nb_plots = len(cls._ions) + 2
custom_cycler = None
if (states.ndim > 3): # circuit in parallel
states = np.reshape(np.swapaxes(states,-2,-1), (states.shape[0], states.shape[1], -1))
custom_cycler = cycler('color', utils.COLORS.repeat(y_states[cls.V_pos].shape[1]))
y_states = [np.reshape(y, (y.shape[0], -1)) if y is not None else None for y in y_states]
# Plot voltage
p = plt.subplot(nb_plots, 1, 1)
if custom_cycler is not None:
p.set_prop_cycle(custom_cycler)
plt.plot(ts, states[:, cls.V_pos], linewidth=l)
if y_states is not None:
if y_states[cls.V_pos] is not None:
plt.plot(ts, y_states[cls.V_pos], 'r', linestyle=targstyle, linewidth=lt, label='target model')
plt.legend()
plt.ylabel('Voltage (mV)')
for i, (ion, pos) in enumerate(cls._ions.items()):
p = plt.subplot(nb_plots, 1, 2+i)
if custom_cycler is not None:
p.set_prop_cycle(custom_cycler)
plt.plot(ts, states[:, pos], linewidth=l)
if y_states is not None:
if y_states[pos] is not None:
plt.plot(ts, y_states[pos], 'r', linestyle=targstyle, linewidth=lt, label='target model')
plt.legend()
plt.ylabel('[{}]'.format(ion))
plt.subplot(nb_plots, 1, nb_plots)
plt.plot(ts, i_inj, 'b')
plt.xlabel('t (ms)')
plt.ylabel('$I_{inj}$ ($\\mu{A}/cm^2$)')
utils.save_show(show, save, utils.IMG_DIR + 'output_%s' % suffix)
def hhsimp_box(df):
utils.box(df, ['b', 'g', 'm', 'g', 'm'], ['C_m', 'g_L', 'g_K', 'E_L', 'E_K'])
plt.title('Membrane')
utils.save_show(True, True, 'boxmemb', dpi=300)
plt.subplot(3, 1, 1)
utils.box(df, ['m', '#610395'], ['a__mdp', 'b__mdp'])
plt.title('Midpoint')
plt.subplot(3, 1, 2)
utils.box(df, ['m', '#610395'], ['a__scale', 'b__scale'])
plt.title('Scale')
plt.subplot(3, 1, 3)
utils.box(df, ['m', '#610395'], ['a__tau', 'b__tau'])
plt.yscale('log')
plt.title('Time constant')
plt.tight_layout()
utils.save_show(True, True, 'boxrates', dpi=300)
def plot_results(self,
ts,
i_inj_values,
results,
ca_true=None,
suffix="",
show=True,
save=False):
V = results[:, 0]
a = results[:, 1]
b = results[:, 2]
il = self._i_L(V)
ik = self._i_K(a, b, V)
plt.figure()
plt.subplot(4, 1, 1)
plt.plot(ts, V, 'k')
plt.title('Leaky Integrator Neuron')
plt.ylabel('V (mV)')
plt.subplot(4, 1, 2)
plt.plot(ts, il, 'g', label='$I_{L}$')
plt.plot(ts, ik, 'c', label='$I_{K}$')
plt.ylabel('Current')
plt.legend()
plt.subplot(4, 1, 3)
plt.plot(ts, a, 'c', label='a')
plt.plot(ts, b, 'b', label='b')
plt.ylabel('Gating Value')
plt.legend()
plt.subplot(4, 1, 4)
plt.plot(ts, i_inj_values, 'b')
plt.xlabel('t (ms)')
plt.ylabel('$I_{inj}$ ($\\mu{A}/cm^2$)')
# plt.ylim(-1, 40)
utils.save_show(show, save, name='Results_{}'.format(suffix), dpi=300)
def boxplot_vars(var_dic, suffix="", show=False, save=True):
df = pd.DataFrame.from_dict(var_dic)
plt.figure()
plt.subplot(121)
cols = [RATE_COLORS['n'], RATE_COLORS['n'], RATE_COLORS['f'], 'k']
box(df, cols, CONDS)
plt.title('Conductances')
plt.subplot(122)
cols = ['b', RATE_COLORS['n'], RATE_COLORS['f'], 'k']
box(df, cols, MEMB)
# plt.plot([DEFAULT[m] for m in MEMB], 'r', marker='*', linestyle='', markersize=10)
plt.title('Membrane')
utils.save_show(show,
save,
name='{}MEmbrane_{}'.format(utils.NEUR_DIR,
suffix).format(suffix),
dpi=300)
plt.figure()
plt.subplot(211)
box(df, ['#666666'], ['rho_ca'])
plt.title('Rho_ca')
plt.yscale('log')
plt.subplot(212)
box(df, ['#0000ff'], ['decay_ca']) # , 'b')
plt.title('Decay_ca')
plt.tight_layout()
utils.save_show(show,
save,
name='{}CalciumPump_{}'.format(utils.NEUR_DIR, suffix),
dpi=300)
plt.figure()
for i, type in enumerate(['mdp', 'scale', 'tau']):
plt.subplot(3, 1, i + 1)
plt.title(type)
labels = [
'{}__{}'.format(rate, type) for rate in RATE_COLORS.keys()
]
cols = RATE_COLORS.values()
if (type == 'tau'):
labels = ['h__alpha' if x == 'h__tau' else x for x in labels]
plt.yscale('log')
box(df, cols, labels)
utils.save_show(show,
save,
name='{}Rates_{}'.format(utils.NEUR_DIR, suffix),
dpi=300)
if __name__ == '__main__':
show_res('Forward_celeggrouprealeq0.2', -1)
get_data()
get_curr()
with open('forward_input', 'rb') as f:
cur = pickle.load(f)
df = pd.DataFrame(cur.transpose(), index=labels.values())
sns.heatmap(df, cmap='jet')
plt.title('Membrane potentials (mV)')
plt.xlabel('Time (ms)')
plt.ylabel('Neuron')
utils.save_show(False, False, 'Input Current', dpi=300)
suffix = sys.argv[1]
for i, m in enumerate(cfg_model.models):
if cfg_model.NEURON_MODEL == m:
suffix = cfg_model.models_name[i] + suffix
break
if fake:
suffix = suffix + 'fake'
else:
suffix = suffix + 'real'
if eq_cost:
suffix = suffix + 'eqcost'
else:
suffix = suffix + 'difcost'
suffix = suffix + str(dt)
def study_vars(cls, p, suffix='', target=None, show=False, save=True):
cls.plot_vars(p,
func=utils.bar,
suffix='compared_%s' % suffix,
show=show,
save=save)
cls.boxplot_vars(p, suffix='boxes_%s' % suffix, show=show, save=save)
if p['C_m'].shape != (1, ):
corr = pd.DataFrame(p).corr()
plt.subplots(figsize=(11, 9))
# Generate a custom diverging colormap
cmap = sns.diverging_palette(220, 10, as_cmap=True)
# Draw the heatmap with the mask and correct aspect ratio
sns.heatmap(corr,
cmap=cmap,
center=0,
square=True,
linewidths=.5,
cbar_kws={"shrink": .5})
utils.save_show(show=show,
save=save,
name='{}Correlation_{}'.format(
utils.NEUR_DIR, suffix))
# def comp(toto, curs):
# import time
# st = time.time()
# v = toto.calculate_exc(curs)[:, 0]
# print('explicit', time.time() - st)
# plt.subplot(2, 1, 1)
# plt.plot(np.arange(0, len(v) * toto.dt, toto.dt), v, 'r')
# plt.xlabel('Time (ms)')
# plt.ylabel('Voltage (mV)')
# plt.title('Explicit solver, dt=%sms' % toto.dt)
# st = time.time()
# v = toto.calculate(curs)[:, 0]
# print('implicit', time.time() - st)
# plt.subplot(2, 1, 2)
# plt.plot(np.arange(0, len(v) * toto.dt, toto.dt), v, 'g')
# plt.xlabel('Time (ms)')
# plt.ylabel('Voltage (mV)')
# plt.title('Implicit-explicit solver, dt=%sms' % toto.dt)
# plt.tight_layout()
# plt.savefig('/home/marcus/Pictures/thesisreport/solversdt%s' % toto.dt, dpi=250)
# plt.close()
#
# def step_exc(self, X, i_inj):
# """Integrate and update voltage after one time step
#
# Args:
# X(np.array or tensor): state vector
# i_inj(np.array or tensor): input current
#
# """
# V = X[self.V_pos]
# p = X[1]
# q = X[2]
# n = X[3]
# e = X[4]
# f = X[5]
# cac = X[-1]
#
# h = self._h(cac)
# V = V + ((i_inj - self._i_ca(V, e, f, h) - self._i_ks(V, n) - self._i_kf(V, p, q) - self._i_leak(V)) /
# self._param[
# 'C_m']) * self.dt
#
# cac = cac + (-self._i_ca(V, e, f, h) * self._param['rho_ca'] - (
# (cac - self.REST_CA) / self._param['decay_ca'])) * self.dt
# p = self._update_gate(p, 'p', V)
# q = self._update_gate(q, 'q', V)
# n = self._update_gate(n, 'n', V)
# e = self._update_gate(e, 'e', V)
# f = self._update_gate(f, 'f', V)
#
# if self._tensors:
# return tf.stack([V, p, q, n, e, f, cac], 0)
# else:
# return np.array([V, p, q, n, e, f, cac])
# @staticmethod
# def ica_from_v(X, v_fix, self):
# e = X[1]
# f = X[2]
# cac = X[-1]
#
# h = self._h(cac)
# tau = self._param['e__tau']
# e = ((tau * self.dt) / (tau + self.dt)) * ((e / self.dt) + (self._inf(v_fix, 'e') / tau))
# tau = self._param['f__tau']
# f = ((tau * self.dt) / (tau + self.dt)) * ((f / self.dt) + (self._inf(v_fix, 'f') / tau))
# ica = self._i_ca(v_fix, e, f, h)
# cac += (-self._i_ca(v_fix, e, f, h) * self._param['rho_ca'] - (
# (cac - self.REST_CA) / self._param['decay_ca'])) * self.dt
#
# if self._tensors:
# return tf.stack([ica, e, f, h, cac], 0)
# else:
# return [ica, e, f, h, cac]
#
# @staticmethod
# def ik_from_v(X, v_fix, self):
# p = X[1]
# q = X[2]
# n = X[3]
#
# tau = self._param['p__tau']
# p = ((tau * self.dt) / (tau + self.dt)) * ((p / self.dt) + (self._inf(v_fix, 'p') / tau))
# tau = self._param['q__tau']
# q = ((tau * self.dt) / (tau + self.dt)) * ((q / self.dt) + (self._inf(v_fix, 'q') / tau))
# tau = self._param['n__tau']
# n = ((tau * self.dt) / (tau + self.dt)) * ((n / self.dt) + (self._inf(v_fix, 'n') / tau))
# ik = self._i_kf(v_fix, p, q) + self._i_ks(v_fix, n)
#
# if self._tensors:
# return tf.stack([ik, p, q, n], 0)
# else:
# return [ik, p, q, n]
#
#
# def plots_ica_from_v(ts, V, results, name="ica", show=False, save=True):
# """plot i_ca and Ca conc depending on the voltage
#
# Args:
# ts:
# V:
# results:
# name: (Default value = "ica")
# show(bool): If True, show the figure (Default value = True)
# save(bool): If True, save the figure (Default value = False)
#
# Returns:
#
# """
# ica = results[:, 0]
# e = results[:, 1]
# f = results[:, 2]
# h = results[:, 3]
# cac = results[:, -1]
#
# plt.figure()
#
# plt.subplot(4, 1, 1)
# plt.title('Hodgkin-Huxley Neuron : I_ca from a fixed V')
# plt.plot(ts, ica, 'b')
# plt.ylabel('I_ca')
#
# plt.subplot(4, 1, 2)
# plt.plot(ts, cac, 'r')
# plt.ylabel('$Ca^{2+}$ concentration')
#
# plt.subplot(4, 1, 3)
# plt.plot(ts, e, RATE_COLORS['e'], label='e')
# plt.plot(ts, f, RATE_COLORS['f'], label='f')
# plt.plot(ts, h, RATE_COLORS['h'], label='h')
# plt.ylabel('Gating Value')
# plt.legend()
#
# plt.subplot(4, 1, 4)
# plt.plot(ts, V, 'k')
# plt.ylabel('V (input) (mV)')
# plt.xlabel('t (ms)')
#
# utils.save_show(show, save, name)
#
#
# def plots_ik_from_v(ts, V, results, name="ik", show=True, save=False):
# """plot i_k depending on the voltage
#
# Args:
# ts:
# V:
# results:
# name: (Default value = "ik")
# show(bool): If True, show the figure (Default value = True)
# save(bool): If True, save the figure (Default value = False)
#
# Returns:
#
# """
# ik = results[:, 0]
# p = results[:, 1]
# q = results[:, 2]
# n = results[:, 3]
#
# plt.figure()
#
# plt.subplot(3, 1, 1)
# plt.title('Hodgkin-Huxley Neuron : I_ca from a fixed V')
# plt.plot(ts, ik, 'b')
# plt.ylabel('I_k')
#
# plt.subplot(3, 1, 2)
# plt.plot(ts, p, RATE_COLORS['p'], label='p')
# plt.plot(ts, q, RATE_COLORS['q'], label='q')
# plt.plot(ts, n, RATE_COLORS['n'], label='n')
# plt.ylabel('Gating Value')
# plt.legend()
#
# plt.subplot(3, 1, 3)
# plt.plot(ts, V, 'k')
# plt.ylabel('V (input) (mV)')
# plt.xlabel('t (ms)')
#
# utils.save_show(show, save, name)
# plt.close()
def plot_vars(cls,
var_dic,
suffix="evolution",
show=False,
save=True,
func=utils.plot):
"""plot variation/comparison/boxplots of all variables organized by categories
Args:
var_dic:
suffix: (Default value = "")
show(bool): If True, show the figure (Default value = True)
save(bool): If True, save the figure (Default value = False)
func: (Default value = plot)
Returns:
"""
fig = plt.figure()
grid = plt.GridSpec(2, 3)
for nb in range(len(GATES)):
gate = GATES[nb]
cls.plot_vars_gate(gate,
var_dic['{}__mdp'.format(gate)],
var_dic['{}__scale'.format(gate)],
var_dic['{}__tau'.format(gate)],
fig,
grid[nb], (nb % 3 == 0),
func=func)
cls.plot_vars_gate('h',
var_dic['h__mdp'],
var_dic['h__scale'],
var_dic['h__alpha'],
fig,
grid[5],
False,
func=func)
plt.tight_layout()
utils.save_show(show,
save,
name='{}Rates_{}'.format(utils.NEUR_DIR, suffix),
dpi=300)
fig = plt.figure()
grid = plt.GridSpec(1, 2)
subgrid = gridspec.GridSpecFromSubplotSpec(4, 1, grid[0], hspace=0.1)
for i, var in enumerate(CONDS):
ax = plt.Subplot(fig, subgrid[i])
func(ax, var_dic[var]) # )
ax.set_ylabel(var)
if (i == 0):
ax.set_title('Conductances')
fig.add_subplot(ax)
subgrid = gridspec.GridSpecFromSubplotSpec(4, 1, grid[1], hspace=0.1)
for i, var in enumerate(MEMB):
ax = plt.Subplot(fig, subgrid[i])
func(ax, var_dic[var]) # )
ax.set_ylabel(var)
if (i == 0):
ax.set_title('Membrane')
ax.yaxis.tick_right()
fig.add_subplot(ax)
plt.tight_layout()
utils.save_show(show,
save,
name='{}Membrane_{}'.format(utils.NEUR_DIR, suffix),
dpi=300)
plt.figure()
ax = plt.subplot(211)
func(ax, var_dic['rho_ca']) # , 'r')
plt.ylabel('Rho_ca')
plt.yscale('log')
ax = plt.subplot(212)
func(ax, var_dic['decay_ca']) # , 'b')
plt.ylabel('Decay_ca')
utils.save_show(show,
save,
name='{}CalciumPump_{}'.format(utils.NEUR_DIR, suffix),
dpi=300)
def plot_results(self,
ts,
i_inj_values,
results,
ca_true=None,
suffix="",
show=True,
save=False):
"""plot all dynamics
Args:
ts:
i_inj_values:
results:
ca_true: (Default value = None)
suffix: (Default value = "")
show(bool): If True, show the figure (Default value = True)
save(bool): If True, save the figure (Default value = False)
Returns:
"""
V = results[:, 0]
p = results[:, 1]
q = results[:, 2]
n = results[:, 3]
e = results[:, 4]
f = results[:, 5]
cac = results[:, 6]
h = self._h(cac)
ica = self._i_ca(V, e, f, h)
ik = self._i_ks(V, n) + self._i_kf(V, p, q)
il = self._i_leak(V)
plt.figure()
plt.subplot(5, 1, 1)
plt.title('C.elegans Hodgkin-Huxley Neuron')
if (V.ndim == 1):
plt.plot(ts, V, 'k')
else:
plt.plot(ts, V)
plt.ylabel('V (mV)')
plt.subplot(5, 1, 2)
if (ca_true is not None):
plt.plot(ts, ca_true, 'Navy', linestyle='-.', label='real data')
plt.legend()
if (V.ndim == 1):
plt.plot(ts, cac, 'r')
else:
plt.plot(ts, cac)
plt.ylabel('[$Ca^{2+}$]')
plt.subplot(5, 1, 3)
plt.plot(ts, ica, RATE_COLORS['f'], label='$I_{Ca}$')
plt.plot(ts, ik, 'm', label='$I_{K}$')
plt.plot(ts, il, 'g', label='$I_{L}$')
plt.ylabel('Current')
plt.legend()
plt.subplot(5, 1, 4)
plt.plot(ts, p, RATE_COLORS['p'], label='p')
plt.plot(ts, q, RATE_COLORS['q'], label='q')
plt.plot(ts, n, RATE_COLORS['n'], label='n')
plt.plot(ts, e, RATE_COLORS['e'], label='e')
plt.plot(ts, f, RATE_COLORS['f'], label='f')
plt.plot(ts, h, RATE_COLORS['h'], label='h')
plt.ylabel('Gating Value')
plt.legend()
plt.subplot(5, 1, 5)
plt.plot(ts, i_inj_values, 'b')
plt.xlabel('t (ms)')
plt.ylabel('$I_{inj}$ ($\\mu{A}/cm^2$)')
# plt.ylim(-1, 40)
utils.save_show(show, save, name='Results_{}'.format(suffix), dpi=300)
def leak_box(df):
utils.box(df, ['b', 'g', 'Gold'], ['C_m', 'g_L', 'E_L'])
plt.title('Membrane')
utils.save_show(True, True, 'box1', dpi=300)
# utils.save_show(True, True, 'dispreal', dpi=300)
dd = optim.get_vars_all(dir, losses=True)
optim.plot_loss_rate(dd['loss'], dd['rates'], dd['loss_test'], 50, show=True)
from odynn import datas
dic = optim.get_vars(dir, loss=True)
train, test = optim.get_data(dir)
print(dic['loss'])
df = pd.DataFrame(dic['loss'], columns=['loss'])
# df = pd.DataFrame.from_dict(dic)#.head(4)
df = df.sort_values('loss').reset_index(drop=True)
# df = df.dropna()
sns.barplot(x=df.index, y='loss', data=df)
# df.plot.bar(y='loss')
utils.save_show(True, True, 'lossfin_virt', dpi=300);exit()
# df = df[df['loss'] <= np.min(df['loss'])]
# hhsimp_box(df)
# cfg_model.NEURON_MODEL.boxplot_vars(dic, show=True, save=True)
dic = df.to_dict('list')
# dic = collections.OrderedDict(sorted(dic.items(), key=lambda t: t[0]))
# obj = circuit.CircuitTf.create_random(n_neuron=9, syn_keys={(i,i+1):True for i in range(8)}, gap_keys={}, n_rand=50, dt=0.1)
p = optim.get_best_result(dir)
print(p)
# p = {k: v[0] for k,v in p.items()}
for i in range(train[1].shape[-1]):
ns.comp_pars_targ(p, cfg_model.NEURON_MODEL.default_params, dt=train[0][1] - train[0][0], i_inj=train[1][:,i], suffix='virtrain%s'%i, show=True, save=True)
for i in range(test[1].shape[-1]):
ns.comp_pars_targ(p, cfg_model.NEURON_MODEL.default_params, dt=test[0][1] - test[0][0], i_inj=test[1][:,i], suffix='virtest%s'%i, show=True, save=True)
