def updateAdjustedMismatches(fN, fF, guValue = .5, otherValue = 1.0):
NX = Nexus(fN, fF)
NX.load(['sigMask', 'adjustedNumMismatches'])
while NX.nextID():
mask = NX.sigMask
numGU = mask.count('G')
numGapAndMM = mask.count('X')
NX.adjustedNumMismatches = (numGU * guValue) + (numGapAndMM * otherValue)
NX.save()
